This research reports VascularPilot3D, the first 3D fully autonomous endovascular robot navigation system. As an exploration toward autonomous guidewire navigation, VascularPilot3D is developed as a complete navigation system based on intra-operative imaging systems (fluoroscopic X-ray in this study) and typical endovascular robots. VascularPilot3D adopts previously researched fast 3D-2D vessel registration algorithms and guidewire segmentation methods as its perception modules. We additionally propose three modules: a topology-constrained 2D-3D instrument end-point lifting method, a tree-based fast path planning algorithm, and a prior-free endovascular navigation strategy. VascularPilot3D is compatible with most mainstream endovascular robots. Ex-vivo experiments validate that VascularPilot3D achieves 100% success rate among 25 trials. It reduces the human surgeon's overall control loops by 18.38%. VascularPilot3D is promising for general clinical autonomous endovascular navigations.

Precise localization of coronary arteries in Computed Tomography (CT) scans is critical from the perspective of medical assessment of coronary artery disease. Although various methods exist that offer high-quality segmentation of coronary arteries in cardiac contrast-enhanced CT scans, the potential of less invasive, non-contrast CT in this area is still not fully exploited. Since such fine anatomical structures are hardly visible in this type of medical images, the existing methods are characterized by high recall and low precision, and are used mainly for filtering of atherosclerotic plaques in the context of calcium scoring. In this paper, we address this research gap and introduce a deep learning algorithm for segmenting coronary arteries in multi-vendor ECG-gated non-contrast cardiac CT images which benefits from a novel framework for semi-automatic generation of Ground Truth (GT) via image registration. We hypothesize that the proposed GT generation process is much more efficient in this case than manual segmentation, since it allows for a fast generation of large volumes of diverse data, which leads to well-generalizing models. To investigate and thoroughly evaluate the segmentation quality based on such an approach, we propose a novel method for manual mesh-to-image registration, which is used to create our test-GT. The experimental study shows that the trained model has significantly higher accuracy than the GT used for training, and leads to the Dice and clDice metrics close to the interrater variability.

Cardiovascular disease (CVD) accounts for about half of non-communicable diseases. Vessel stenosis in the coronary artery is considered to be the major risk of CVD. Computed tomography angiography (CTA) is one of the widely used noninvasive imaging modalities in coronary artery diagnosis due to its superior image resolution. Clinically, segmentation of coronary arteries is essential for the diagnosis and quantification of coronary artery disease. Recently, a variety of works have been proposed to address this problem. However, on one hand, most works rely on in-house datasets, and only a few works published their datasets to the public which only contain tens of images. On the other hand, their source code have not been published, and most follow-up works have not made comparison with existing works, which makes it difficult to judge the effectiveness of the methods and hinders the further exploration of this challenging yet critical problem in the community. In this paper, we propose a large-scale dataset for coronary artery segmentation on CTA images. In addition, we have implemented a benchmark in which we have tried our best to implement several typical existing methods. Furthermore, we propose a strong baseline method which combines multi-scale patch fusion and two-stage processing to extract the details of vessels. Comprehensive experiments show that the proposed method achieves better performance than existing works on the proposed large-scale dataset. The benchmark and the dataset are published at https://github.com/XiaoweiXu/ImageCAS-A-Large-Scale-Dataset-and-Benchmark-for-Coronary-Artery-Segmentation-based-on-CT.

Coronary Artery Diseases although preventable are one of the leading cause of mortality worldwide. Due to the onerous nature of diagnosis, tackling CADs has proved challenging. This study addresses the automation of resource-intensive and time-consuming process of manually detecting stenotic lesions in coronary arteries in X-ray coronary angiography images. To overcome this challenge, we employ a specialized Convnext-V2 backbone based Mask RCNN model pre-trained for instance segmentation tasks. Our empirical findings affirm that the proposed model exhibits commendable performance in identifying stenotic lesions. Notably, our approach achieves a substantial F1 score of 0.5353 in this demanding task, underscoring its effectiveness in streamlining this intensive process.

Ultrasound (US) imaging is widely used for diagnosing and monitoring arterial diseases, mainly due to the advantages of being non-invasive, radiation-free, and real-time. In order to provide additional information to assist clinicians in diagnosis, the tubular structures are often segmented from US images. To improve the artery segmentation accuracy and stability during scans, this work presents a novel pulsation-assisted segmentation neural network (PAS-NN) by explicitly taking advantage of the cardiac-induced motions. Motion magnification techniques are employed to amplify the subtle motion within the frequency band of interest to extract the pulsation signals from sequential US images. The extracted real-time pulsation information can help to locate the arteries on cross-section US images; therefore, we explicitly integrated the pulsation into the proposed PAS-NN as attention guidance. Notably, a robotic arm is necessary to provide stable movement during US imaging since magnifying the target motions from the US images captured along a scan path is not manually feasible due to the hand tremor. To validate the proposed robotic US system for imaging arteries, experiments are carried out on volunteers' carotid and radial arteries. The results demonstrated that the PAS-NN could achieve comparable results as state-of-the-art on carotid and can effectively improve the segmentation performance for small vessels (radial artery).