Recent studies have demonstrated the feasibility of modeling single-cell data as natural languages and the potential of leveraging powerful large language models (LLMs) for understanding cell biology. However, a comprehensive evaluation of LLMs' performance on language-driven single-cell analysis tasks remains unexplored. Motivated by this challenge, we introduce CELLVERSE, a unified language-centric question-answering benchmark that integrates four types of single-cell multi-omics data and encompasses three hierarchical levels of single-cell analysis tasks: cell type annotation (cell-level), drug response prediction (drug-level), and perturbation analysis (gene-level). Going beyond this, we systematically evaluate the performance across 14 open-source and closed-source LLMs ranging 160M 671B on CELLVERSE. Remarkably, the experimental results reveal: Existing specialist models (e.g., C2S-Pythia) fail to make reasonable decisions across all sub-tasks within CELLVERSE, while generalist models such as Qwen, Llama, GPT, and DeepSeekfamily models exhibit preliminary understanding capabilities within the realm of cell biology. The performance of current LLMs falls short of expectations and has substantial room for improvement. Notably, in the widely studied drug response prediction task, none of the evaluated LLMs demonstrate significant performance improvement over random guessing. CELLVERSE offers the first large-scale empirical demonstration that significant challenges still remain in applying LLMs to cell biology. By introducing CELLVERSE, we lay the foundation for advancing cell biology through natural languages and hope this paradigm could facilitate next-generation single-cell analysis.

However, most state-of-art neural models are known to be data-hungry and require substantial training data.

Research into explainable artificial intelligence (XAI) for data analysis tasks suffer from a large number of contradictions and lack of concrete design recommendations stemming from gaps in understanding the tasks that require AI assistance. In this paper, we drew on multiple fields such as visual analytics, cognition, and dashboard design to propose a method for categorising and comparing XAI studies under three dimensions: what, why, and who. We identified the main problems as: inadequate descriptions of tasks, context-free studies, and insufficient testing with target users. We propose that studies should specifically report on their users' domain, AI, and data analysis expertise to illustrate the generalisability of their findings. We also propose study guidelines for designing and reporting XAI tasks to improve the XAI community's ability to parse the rapidly growing field. We hope that our contribution can help researchers and designers better identify which studies are most relevant to their work, what gaps exist in the research, and how to handle contradictory results regarding XAI design.

Single-cell RNA sequencing (scRNA-seq) technology has profiled hundreds of millions of human cells across organs, diseases, development and perturbations to date. However, the high-dimensional sparsity, batch effect noise, category imbalance, and ever-increasing data scale of the original sequencing data pose significant challenges for multi-center knowledge transfer, data fusion, and cross-validation between scRNA-seq datasets. To address these barriers, (1) we first propose a latent codes-based scRNA-seq dataset distillation framework named scDD, which transfers and distills foundation model knowledge and original dataset information into a compact latent space and generates synthetic scRNA-seq dataset by a generator to replace the original dataset. Then, (2) we propose a single-step conditional diffusion generator named SCDG, which perform single-step gradient back-propagation to help scDD optimize distillation quality and avoid gradient decay caused by multi-step back-propagation. Meanwhile, SCDG ensures the scRNA-seq data characteristics and inter-class discriminability of the synthetic dataset through flexible conditional control and generation quality assurance. Finally, we propose a comprehensive benchmark to evaluate the performance of scRNA-seq dataset distillation in different data analysis tasks. It is validated that our proposed method can achieve 7.61% absolute and 15.70% relative improvement over previous state-of-the-art methods on average task.

Merging natural language interfaces with computational fluid dynamics (CFD) workflows presents transformative opportunities for both industry and research. In this study, we introduce OptMetaOpenFOAM - a novel framework that bridges MetaOpenFOAM with external analysis and optimization tool libraries through a large language model (LLM)-driven chain-of-thought (COT) methodology. By automating complex CFD tasks via natural language inputs, the framework empowers non-expert users to perform sensitivity analyses and parameter optimizations with markedly improved efficiency. The test dataset comprises 11 distinct CFD analysis or optimization tasks, including a baseline simulation task derived from an OpenFOAM tutorial covering fluid dynamics, combustion, and heat transfer. Results confirm that OptMetaOpenFOAM can accurately interpret user requirements expressed in natural language and effectively invoke external tool libraries alongside MetaOpenFOAM to complete the tasks. Furthermore, validation on a non-OpenFOAM tutorial case - namely, a hydrogen combustion chamber - demonstrates that a mere 200-character natural language input can trigger a sequence of simulation, postprocessing, analysis, and optimization tasks spanning over 2,000 lines of code. These findings underscore the transformative potential of LLM-driven COT methodologies in linking external tool for advanced analysis and optimization, positioning OptMetaOpenFOAM as an effective tool that streamlines CFD simulations and enhances their convenience and efficiency for both industrial and research applications. Code is available at https://github.com/Terry-cyx/MetaOpenFOAM.

It is beyond dispute that the potential benefits of artificial intelligence (AI) in military intelligence are considerable. Nevertheless, it remains uncertain precisely how AI can enhance the analysis of military data. The aim of this study is to address this issue. To this end, the AI demonstrator deepCOM was developed in collaboration with the start-up Aleph Alpha. The AI functions include text search, automatic text summarization and Named Entity Recognition (NER). These are evaluated for their added value in military analysis. It is demonstrated that under time pressure, the utilization of AI functions results in assessments clearly superior to that of the control group. Nevertheless, despite the demonstrably superior analysis outcome in the experimental group, no increase in confidence in the accuracy of their own analyses was observed. Finally, the paper identifies the limitations of employing AI in military intelligence, particularly in the context of analyzing ambiguous and contradictory information.

Live comments, also known as Danmaku, are user-generated messages that are synchronized with video content. These comments overlay directly onto streaming videos, capturing viewer emotions and reactions in real-time. While prior work has leveraged live comments in affective analysis, its use has been limited due to the relative rarity of live comments across different video platforms. To address this, we first construct the Live Comment for Affective Analysis (LCAffect) dataset which contains live comments for English and Chinese videos spanning diverse genres that elicit a wide spectrum of emotions. Then, using this dataset, we use contrastive learning to train a video encoder to produce synthetic live comment features for enhanced multimodal affective content analysis. Through comprehensive experimentation on a wide range of affective analysis tasks (sentiment, emotion recognition, and sarcasm detection) in both English and Chinese, we demonstrate that these synthetic live comment features significantly improve performance over state-of-the-art methods.