In medical imaging, technical progress or changes in diagnostic procedures lead to a continuous change in image appearance. Scanner manufacturer, reconstruction kernel, dose, other protocol specific settings or administering of contrast agents are examples that influence image content independent of the scanned biology. Such domain and task shifts limit the applicability of machine learning algorithms in the clinical routine by rendering models obsolete over time. Here, we address the problem of data shifts in a continuous learning scenario by adapting a model to unseen variations in the source domain while counteracting catastrophic forgetting effects. Our method uses a dynamic memory to facilitate rehearsal of a diverse training data subset to mitigate forgetting. We evaluated our approach on routine clinical CT data obtained with two different scanner protocols and synthetic classification tasks. Experiments show that dynamic memory counters catastrophic forgetting in a setting with multiple data shifts without the necessity for explicit knowledge about when these shifts occur.

Continual learning of deep neural networks is a key requirement for scaling them up to more complex applicative scenarios and for achieving real lifelong learning of these architectures. Previous approaches to the problem have considered either the progressive increase in the size of the networks, or have tried to regularize the network behavior to equalize it with respect to previously observed tasks. In the latter case, it is essential to understand what type of information best represents this past behavior. Common techniques include regularizing the past outputs, gradients, or individual weights. In this work, we propose a new, relatively simple and efficient method to perform continual learning by regularizing instead the network internal embeddings. To make the approach scalable, we also propose a dynamic sampling strategy to reduce the memory footprint of the required external storage. We show that our method performs favorably with respect to state-of-the-art approaches in the literature, while requiring significantly less space in memory and computational time. In addition, inspired inspired by to recent works, we evaluate the impact of selecting a more flexible model for the activation functions inside the network, evaluating the impact of catastrophic forgetting on the activation functions themselves.

Humans and most animals can learn new tasks without forgetting old ones. However, training artificial neural networks (ANNs) on new tasks typically cause it to forget previously learned tasks. This phenomenon is the result of "catastrophic forgetting", in which training an ANN disrupts connection weights that were important for solving previous tasks, degrading task performance. Several recent studies have proposed methods to stabilize connection weights of ANNs that are deemed most important for solving a task, which helps alleviate catastrophic forgetting. Here, drawing inspiration from algorithms that are believed to be implemented in vivo, we propose a complementary method: adding a context-dependent gating signal, such that only sparse, mostly non-overlapping patterns of units are active for any one task. This method is easy to implement, requires little computational overhead, and allows ANNs to maintain high performance across large numbers of sequentially presented tasks when combined with weight stabilization. This work provides another example of how neuroscience-inspired algorithms can benefit ANN design and capability.