This event is part of the Demystifying regulation and commercialisation mini-series, hosted through the Christabel Pankhurst Institute for Health Technology Research and Innovation. These events, taking place in June and July 2021, are organised by Advanced Materials in Medicine (AMM), Translation Manchester, Digital Futures, the University of Manchester Innovation Factory, and the Institute of Data Science and AI. Significant AI health technology activity is taking place in the Greater Manchester (GM) region across academic institutions, regional government, SMEs and larger organisations. Examples include the development of the Greater Manchester Care Records (GMCR), which integrates primary, secondary and social care data from 2.8M individuals and the recent establishment of the Christabel Pankhurst Institute for Health Technology Research and Innovation (Pankhurst), a cross-sector multi-partner translational enabler; and the European Regional Development Funded Greater Manchester Research and Innovation Health Accelerator to support regional SMEs. Due to these developments, there is increasing awareness of the emerging evidence requirements to demonstrate the utility of AI-based health technology but less detailed understanding of the specifics of this complex and evolving environment.