Alzheimer s disease


How we recall the past

MIT News

When we have a new experience, the memory of that event is stored in a neural circuit that connects several parts of the hippocampus and other brain structures. Previous research has shown that encoding these memories involves cells in a part of the hippocampus called CA1, which then relays information to another brain structure called the entorhinal cortex. In one group of mice, the MIT team inhibited neurons of the subiculum as the mice underwent fear conditioning, which had no effect on their ability to later recall the experience. However, in another group, they inhibited subiculum neurons after fear conditioning had occurred, when the mice were placed back in the original chamber.


New Machine Learning Program Shows Promise For Early Alzheimer's Diagnosis

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The introduction of mild cognitive impairment (MCI) as a diagnostic category adds to the challenges of diagnosing Alzheimer's Disease (AD). In this work, we present a combined framework, cascaded multiview canonical correlation (CaMCCo), for fusion and cascaded classification that incorporates all diagnostic categories and optimizes classification by selectively combining a subset of modalities at each level of the cascade. Results suggest that fusion of select modalities for each classification task outperforms (mean AUC 0.92) fusion of all modalities (mean AUC 0.54) and individual modalities (mean AUC 0.90, 0.53, 0.71, 0.73, 0.62, 0.68). In addition, CaMCCo outperforms all other multi-class classification methods for MCI prediction (PPV: 0.80 vs. 0.67, 0.63).


Groundbreaking drug could treat childhood Alzheimer's

Daily Mail

The disease, Niemann-Pick type C (NPC), causes cholesterol build up in the neurons, leading to enlarged organs, lung damage, muscle stiffness, seizures, dementia and difficulty speaking. The test, which is called the NPC Neurological Severity Score, helps assess eye movement, gait, speech, swallowing, fine motor skills, cognition, hearing, memory and presence and severity of seizures. The historical data showed patients' scores increased - meaning the disease worsened - an average of 2.9 points per year. The progressive, fatal condition, officially known as Niemann-Pick disease type C, causes enlarged organs, lung damage, muscle stiffness, dementia and difficulty speaking.


New AI algorithm monitors sleep with radio waves

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More than 50 million Americans suffer from sleep disorders, and diseases including Parkinson's and Alzheimer's can also disrupt sleep. To make it easier to diagnose and study sleep problems, researchers at MIT and Massachusetts General Hospital have devised a new way to monitor sleep stages without sensors attached to the body. Their device uses an advanced artificial intelligence algorithm to analyze the radio signals around the person and translate those measurements into sleep stages: light, deep, or rapid eye movement (REM). Recent advances in artificial intelligence have made it possible to train computer algorithms known as deep neural networks to extract and analyze information from complex datasets, such as the radio signals obtained from the researchers' sensor.


Miniature test tube brains could cure Alzheimer's disease

Daily Mail

Dementia is a progressive neurological disease which affects multiple brain functions, including memory. Dementia is a progressive neurological disease which affects multiple brain functions, including memory. These help them'unlearn' that they are skin cells and return to the state of a newborn baby's cells In April, researchers at Stanford University grew two forebrain circuits, measuring only a sixteenth of an inch across, using only human skin cells. In April, researchers at Stanford University grew two forebrain circuits, measuring only a sixteenth of an inch across, using only human skin cells.


new-ai-algorithm-monitors-sleep-radio-waves-0807

MIT News

More than 50 million Americans suffer from sleep disorders, and diseases including Parkinson's and Alzheimer's can also disrupt sleep. To make it easier to diagnose and study sleep problems, researchers at MIT and Massachusetts General Hospital have devised a new way to monitor sleep stages without sensors attached to the body. Their device uses an advanced artificial intelligence algorithm to analyze the radio signals around the person and translate those measurements into sleep stages: light, deep, or rapid eye movement (REM). Recent advances in artificial intelligence have made it possible to train computer algorithms known as deep neural networks to extract and analyze information from complex datasets, such as the radio signals obtained from the researchers' sensor.


IBM's autonomous tech focused on helping those with disabilities

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IBM's foray into autonomous car design focuses on people with disabilities. The technology company last year unveiled its Watson-powered self-driving shuttle, called Olli. Sachin Lulla, global vice president for automotive strategy and solutions leader at IBM, said it's an example of the company's focus on providing personalized experiences for those who may otherwise struggle to drive. The battery-powered and 3-D-printed Olli shuttle includes features such as ramps for passengers in wheelchairs, text-based question-and-answers for hearing-impaired people; verbal commands and sensors on seats so sight-impaired people can easily find an open seat; and reminders for people who leave items behind because of Alzheimer's disease or other cognitive disabilities.


Paper review: 'May's top aide breaks silence'

BBC News

Theresa May's former chief of staff, Nick Timothy, has been speaking to the Daily Telegraph to explain where he thinks the general election campaign went wrong for the Conservatives. The Telegraph says Mr Timothy insisted he would not point the finger of blame but it says his answers leave no doubt of the tensions that existed between Downing Street staff and the election strategists who were brought in, including Sir Lynton Crosby. The Times says comments about Brexit by the Republic of Ireland's Prime Minister Leo Varadkar showed a "marked shift of tone" for Dublin. The Telegraph reports that tiny human brains are being grown in the laboratory and could, one day, be used to repair damage caused by Alzheimer's disease.


Alzheimer's signs found in the brains of chimpanzees

Daily Mail

Researchers say it is unclear whether the characteristic'plaques and tangles' they found cause dementia in the animals Alzheimer's disease is the most common cause of dementia. In the brains of people with Alzheimer's, a protein called beta-amyloid accumulates to form sticky plaques between brain cells. In the brains of Alzheimer's sufferers, beta-amyloid plaques form, causing another protein called tau to form tangles. The human brain may be unique in the cognitive decline that accompanies plaques and tangles, Dr Raghanti said.


Prolonging the lives & independence of Alzheimer's patients with artificial intelligence Drug Delivery Business

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Teaming with up with Dr. Bradford Dickerson and neuropsychologist Bonnie Wong, the group at MyndYou will work to test out its artificial intelligence-enabled technology and assess its ability to objectively detect changes in cognition among patients with primary progressive aphasia. "There is a huge need by clinicians, researchers, pharmaceutical companies and family members, as care providers, for objective data of the changes in the person's cognitive abilities as part of day-to-day life," she told Drug Delivery Business News. While doctors and family members know that the ultimate goal of medicine is to extend life, they also want to ensure that what they do will prolong a patient's independence and quality of life. "We see a great need for tools that can increase effective and personalized care without disrupting the day-to-day life of our patients," Dr. Bradford Dickerson, from the Massachusetts General Hospital's department of neurology, said in prepared remarks.