Neuroscience research has made immense progress over the last decade, but our understanding of the brain remains fragmented and piecemeal: the dream of probing an arbitrary brain region and automatically reading out the information encoded in its neural activity remains out of reach. In this work, we build towards a first foundation model for neural spiking data that can solve a diverse set of tasks across multiple brain areas. We introduce a novel self-supervised modeling approach for population activity in which the model alternates between masking out and reconstructing neural activity across different time steps, neurons, and brain regions. To evaluate our approach, we design unsupervised and supervised prediction tasks using the International Brain Laboratory repeated site dataset, which is comprised of Neuropixels recordings targeting the same brain locations across 48 animals and experimental sessions. The prediction tasks include single-neuron and region-level activity prediction, forward prediction, and behavior decoding. We demonstrate that our multi-task-masking (MtM) approach significantly improves the performance of current state-of-the-art population models and enables multitask learning. We also show that by training on multiple animals, we can improve the generalization ability of the model to unseen animals, paving the way for a foundation model of the brain at single-cell, single-spike resolution.

Given a set of heterogeneous input sequences that capture a common geographic area in varying environmental conditions (e.g.

We'll add a reference to the appendix in the main text of the paper. Catch related: We'll provide more details on the learning to bootstrap results. We'll provide detailed calculation of the theoretical optimal performance in the appendix; 2) We'll add an Robustness of learning a target vs. learning a loss: For any given η the expected target E(g E.g., Figure 3b shows that learning a loss was more fragile and the agent failed to To Reviewer #3: We appreciate your valuable comments! We will add a baseline for [1]. To Reviewer #4: Thanks for noting that our paper tackles a very valuable problem and that the idea is interesting & novel.

Subsequently, we respond to specific comments from individual reviewers. As the reveiwers noted, the main technical results (Theorems 1 and 2) are new. For MDSs (Appendix A), we worked with a quadratic form of dependent r.v.s, had to first The parameter estimation error rate depends on the minimum eigenvalue of the design matrix. We will expand on this LCB application in Sec. 3. We will include a brief sketch of how the terms in (6) are bounded and give some details on what a, b, c are in (7). We appreciate the detailed comments and will update the draft to address these.

In the context of reinforcement learning from human feedback (RLHF), the reward function is generally derived from maximum likelihood estimation of a random utility model based on pairwise comparisons made by humans. The problem of learning a reward function is one of preference aggregation that, we argue, largely falls within the scope of social choice theory. From this perspective, we can evaluate different aggregation methods via established axioms, examining whether these methods meet or fail well-known standards. We demonstrate that both the Bradley-Terry-Luce Model and its broad generalizations fail to meet basic axioms. In response, we develop novel rules for learning reward functions with strong axiomatic guarantees. A key innovation from the standpoint of social choice is that our problem has a linear structure, which greatly restricts the space of feasible rules and leads to a new paradigm that we call linear social choice.

We propose an efficient and robust iterative solution to the multi-object matching problem. We first clarify serious limitations of current methods as well as the inappropriateness of the standard iteratively reweighted least squares procedure. In view of these limitations, we suggest a novel and more reliable iterative reweighting strategy that incorporates information from higher-order neighborhoods by exploiting the graph connection Laplacian. We provide partial theoretical guarantees and demonstrate the superior performance of our procedure over state-of-the-art methods using both synthetic and real datasets.

LiDAR-based 3D object detection has made impressive progress recently, yet most existing models are black-box, lacking interpretability. Previous explanation approaches primarily focus on analyzing image-based models and are not readily applicable to LiDAR-based 3D detectors. In this paper, we propose a feature factorization activation map (FFAM) to generate high-quality visual explanations for 3D detectors. FFAM employs non-negative matrix factorization to generate concept activation maps and subsequently aggregates these maps to obtain a global visual explanation. To achieve object-specific visual explanations, we refine the global visual explanation using the feature gradient of a target object. Additionally, we introduce a voxel upsampling strategy to align the scale between the activation map and input point cloud. We qualitatively and quantitatively analyze FFAM with multiple detectors on several datasets. Experimental results validate the high-quality visual explanations produced by FFAM. The code is available at https://github.com/Say2L/FFAM.git.

Data-driven inference of the generative dynamics underlying a set of observed time series is of growing interest in machine learning and the natural sciences. In neuroscience, such methods promise to alleviate the need to handcraft models based on biophysical principles and allow to automatize the inference of inter-individual differences in brain dynamics. Recent breakthroughs in training techniques for state space models (SSMs) specifically geared toward dynamical systems (DS) reconstruction (DSR) enable to recover the underlying system including its geometrical (attractor) and long-term statistical invariants from even short time series. These techniques are based on control-theoretic ideas, like modern variants of teacher forcing (TF), to ensure stable loss gradient propagation while training. However, as it currently stands, these techniques are not directly applicable to data modalities where current observations depend on an entire history of previous states due to a signal's filtering properties, as common in neuroscience (and physiology more generally).

We consider a generic empirical composition optimization problem, where there are empirical averages present both outside and inside nonlinear loss functions. Such a problem is of interest in various machine learning applications, and cannot be directly solved by standard methods such as stochastic gradient descent. We take a novel approach to solving this problem by reformulating the original minimization objective into an equivalent min-max objective, which brings out all the empirical averages that are originally inside the nonlinear loss functions. We exploit the rich structures of the reformulated problem and develop a stochastic primal-dual algorithm, SVRPDA-I, to solve the problem efficiently. We carry out extensive theoretical analysis of the proposed algorithm, obtaining the convergence rate, the computation complexity and the storage complexity. In particular, the algorithm is shown to converge at a linear rate when the problem is strongly convex. Moreover, we also develop an approximate version of the algorithm, named SVRPDA-II, which further reduces the memory requirement. Finally, we evaluate our proposed algorithms on several real-world benchmarks, and experimental results show that the proposed algorithms significantly outperform existing techniques.

Masked autoencoder has been widely explored in point cloud self-supervised learning, whereby the point cloud is generally divided into visible and masked parts. These methods typically include an encoder accepting visible patches (normalized) and corresponding patch centers (position) as input, with the decoder accepting the output of the encoder and the centers (position) of the masked parts to reconstruct each point in the masked patches. Then, the pre-trained encoders are used for downstream tasks. In this paper, we show a motivating empirical result that when directly feeding the centers of masked patches to the decoder without information from the encoder, it still reconstructs well. In other words, the centers of patches are important and the reconstruction objective does not necessarily rely on representations of the encoder, thus preventing the encoder from learning semantic representations. Based on this key observation, we propose a simple yet effective method, i.e., learning to Predict Centers for Point Masked AutoEncoders (PCP-MAE) which guides the model to learn to predict the significant centers and use the predicted centers to replace the directly provided centers. Specifically, we propose a Predicting Center Module (PCM) that shares parameters with the original encoder with extra cross-attention to predict centers. Our method is of high pre-training efficiency compared to other alternatives and achieves great improvement over Point-MAE, particularly surpassing it by 5.50% on OBJ-BG, 6.03% on OBJ-ONLY, and 5.17% on PB-T50-RS for 3D object classification on the ScanObjectNN dataset.