The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule therapeutics--is a highly complex, resource-intensive, and time-consuming process that requires multidisciplinary collaboration. Recent breakthroughs in artificial intelligence (AI), particularly the rise of large language models (LLMs), present a transformative opportunity to streamline and accelerate this process. In this paper, we introduce PharmAgents, a virtual pharmaceutical ecosystem driven by LLM-based multi-agent collaboration. PharmAgents simulates the full drug discovery workflow--from target discovery to preclinical evaluation--by integrating explainable, LLM-driven agents equipped with specialized machine learning models and computational tools. Through structured knowledge exchange and automated optimization, PharmAgents identifies potential therapeutic targets, discovers promising lead compounds, enhances binding affinity and key molecular properties, and performs in silico analyses of toxicity and synthetic feasibility. Additionally, the system supports interpretability, agent interaction, and self-evolvement, enabling it to refine future drug designs based on prior experience. By showcasing the potential of LLM-powered multi-agent systems in drug discovery, this work establishes a new paradigm for autonomous, explainable, and scalable pharmaceutical research, with future extensions toward comprehensive drug lifecycle management.

In recent work on time-series prediction, Transformers and even large language models have garnered significant attention due to their strong capabilities in sequence modeling. However, in practical deployments, time-series prediction often requires operation in resource-constrained environments, such as edge devices, which are unable to handle the computational overhead of large models. To address such scenarios, some lightweight models have been proposed, but they exhibit poor performance on non-stationary sequences. In this paper, we propose $\textit{SWIFT}$, a lightweight model that is not only powerful, but also efficient in deployment and inference for Long-term Time Series Forecasting (LTSF). Our model is based on three key points: (i) Utilizing wavelet transform to perform lossless downsampling of time series. (ii) Achieving cross-band information fusion with a learnable filter. (iii) Using only one shared linear layer or one shallow MLP for sub-series' mapping. We conduct comprehensive experiments, and the results show that $\textit{SWIFT}$ achieves state-of-the-art (SOTA) performance on multiple datasets, offering a promising method for edge computing and deployment in this task. Moreover, it is noteworthy that the number of parameters in $\textit{SWIFT-Linear}$ is only 25\% of what it would be with a single-layer linear model for time-domain prediction. Our code is available at https://github.com/LancelotXWX/SWIFT.

Permanent magnet tracking using the external sensor array is crucial for the accurate localization of wireless capsule endoscope robots. Traditional tracking algorithms, based on the magnetic dipole model and Levenberg-Marquardt (LM) algorithm, face challenges related to computational delays and the need for initial position estimation. More recently proposed neural network-based approaches often require extensive hardware calibration and real-world data collection, which are time-consuming and labor-intensive. To address these challenges, we propose MobilePosenet, a lightweight neural network architecture that leverages depthwise separable convolutions to minimize computational cost and a channel attention mechanism to enhance localization accuracy. Besides, the inputs to the network integrate the sensors' coordinate information and random noise, compensating for the discrepancies between the theoretical model and the actual magnetic fields and thus allowing MobilePosenet to be trained entirely on theoretical data. Experimental evaluations conducted in a \(90 \times 90 \times 80\) mm workspace demonstrate that MobilePosenet exhibits excellent 5-DOF localization accuracy ($1.54 \pm 1.03$ mm and $2.24 \pm 1.84^{\circ}$) and inference speed (0.9 ms) against state-of-the-art methods trained on real-world data. Since network training relies solely on theoretical data, MobilePosenet can eliminate the hardware calibration and real-world data collection process, improving the generalizability of this permanent magnet localization method and the potential for rapid adoption in different clinical settings.

Ultrasound (US)-guided needle insertion is widely employed in percutaneous interventions. However, providing feedback on the needle tip position via US image presents challenges due to noise, artifacts, and the thin imaging plane of US, which degrades needle features and leads to intermittent tip visibility. In this paper, a Mamba-based US needle tracker MambaXCTrack utilizing structured state space models cross-correlation (SSMX-Corr) and implicit motion prompt is proposed, which is the first application of Mamba in US needle tracking. The SSMX-Corr enhances cross-correlation by long-range modeling and global searching of distant semantic features between template and search maps, benefiting the tracking under noise and artifacts by implicitly learning potential distant semantic cues. By combining with cross-map interleaved scan (CIS), local pixel-wise interaction with positional inductive bias can also be introduced to SSMX-Corr. The implicit low-level motion descriptor is proposed as a non-visual prompt to enhance tracking robustness, addressing the intermittent tip visibility problem. Extensive experiments on a dataset with motorized needle insertion in both phantom and tissue samples demonstrate that the proposed tracker outperforms other state-of-the-art trackers while ablation studies further highlight the effectiveness of each proposed tracking module.

They have shown a promising prospect in automatically completing tasks upon user instructions, functioning as brain-like coordinators. The associated risks will be revealed as we delegate an increasing number of tasks to machines for automated completion. A big question emerges: how can we make machines behave responsibly when helping humans automate tasks as personal copilots? In this paper, we explore this question in depth from the perspectives of feasibility, completeness and security. In specific, we present Responsible Task Automation (ResponsibleTA) as a fundamental framework to facilitate responsible collaboration between LLM-based coordinators and executors for task automation with three empowered capabilities: 1) predicting the feasibility of the commands for executors; 2) verifying the completeness of executors; 3) enhancing the security (e.g., the protection of users' privacy). We further propose and compare two paradigms for implementing the first two capabilities. One is to leverage the generic knowledge of LLMs themselves via prompt engineering while the other is to adopt domain-specific learnable models. Moreover, we introduce a local memory mechanism for achieving the third capability. We evaluate our proposed ResponsibleTA on UI task automation and hope it could bring more attentions to ensuring LLMs more responsible in diverse scenarios.

The recruitment of trustworthy and high-quality workers is an important research issue for MCS. Previous studies either assume that the qualities of workers are known in advance, or assume that the platform knows the qualities of workers once it receives their collected data. In reality, to reduce costs and thus maximize revenue, many strategic workers do not perform their sensing tasks honestly and report fake data to the platform, which is called False data attacks. And it is very hard for the platform to evaluate the authenticity of the received data. In this paper, an incentive mechanism named Semi-supervision based Combinatorial Multi-Armed Bandit reverse Auction (SCMABA) is proposed to solve the recruitment problem of multiple unknown and strategic workers in MCS. First, we model the worker recruitment as a multi-armed bandit reverse auction problem and design an UCB-based algorithm to separate the exploration and exploitation, regarding the Sensing Rates (SRs) of recruited workers as the gain of the bandit. Next, a Semi-supervised Sensing Rate Learning (SSRL) approach is proposed to quickly and accurately obtain the workers' SRs, which consists of two phases, supervision and self-supervision. Last, SCMABA is designed organically combining the SRs acquisition mechanism with multi-armed bandit reverse auction, where supervised SR learning is used in the exploration, and the self-supervised one is used in the exploitation. We theoretically prove that our SCMABA achieves truthfulness and individual rationality and exhibits outstanding performances of the SCMABA mechanism through in-depth simulations of real-world data traces.

We investigate weakly-supervised image parsing, i.e., assigning class labels to image regions by using image-level labels only. Existing studies pay main attention to the formulation of the weakly-supervised learning problem, i.e., how to propagate class labels from images to regions given an affinity graph of regions. Notably, however, the affinity graph of regions, which is generally constructed in relatively simpler settings in existing methods, is of crucial importance to the parsing performance due to the fact that the weakly-supervised parsing problem cannot be solved within a single image, and that the affinity graph enables label propagation among multiple images. In order to embed more semantics into the affinity graph, we propose novel criteria by exploiting the weak supervision information carefully, and develop two graphs: L1 semantic graph and k-NN semantic graph. Experimental results demonstrate that the proposed semantic graphs not only capture more semantic relevance, but also perform significantly better than conventional graphs in image parsing.

Nowadays images on social networking websites (e.g., Flickr) are mostly accompanied with user-contributed tags, which help cast a new light on the conventional content-based image analysis tasks such as image classification and retrieval. In order to establish a scalable social image analysis system, two issues need to be considered: 1) Supervised learning is a futile task in modeling the enormous number of concepts in the world, whereas unsupervised approaches overcome this hurdle; 2) Algorithms are required to be both spatially and temporally efficient to handle large-scale datasets. In this paper, we propose a cross-view feature learning (CVFL) framework to handle the problem of social image analysis effectively and efficiently. Through explicitly modeling the relevance between image content and tags (which is empirically shown to be visually and semantically meaningful), CVFL yields more promising results than existing methods in the experiments. More importantly, being general and descriptive, CVFL and its variants can be readily applied to other large-scale multi-view tasks in unsupervised setting.