Objective: The artificial pancreas (AP) has shown promising potential in achieving closed-loop glucose control for individuals with type 1 diabetes mellitus (T1DM). However, designing an effective control policy for the AP remains challenging due to the complex physiological processes, delayed insulin response, and inaccurate glucose measurements. While model predictive control (MPC) offers safety and stability through the dynamic model and safety constraints, it lacks individualization and is adversely affected by unannounced meals. Conversely, deep reinforcement learning (DRL) provides personalized and adaptive strategies but faces challenges with distribution shifts and substantial data requirements. Methods: We propose a hybrid control policy for the artificial pancreas (HyCPAP) to address the above challenges. HyCPAP combines an MPC policy with an ensemble DRL policy, leveraging the strengths of both policies while compensating for their respective limitations. To facilitate faster deployment of AP systems in real-world settings, we further incorporate meta-learning techniques into HyCPAP, leveraging previous experience and patient-shared knowledge to enable fast adaptation to new patients with limited available data. Results: We conduct extensive experiments using the FDA-accepted UVA/Padova T1DM simulator across three scenarios. Our approaches achieve the highest percentage of time spent in the desired euglycemic range and the lowest occurrences of hypoglycemia. Conclusion: The results clearly demonstrate the superiority of our methods for closed-loop glucose management in individuals with T1DM. Significance: The study presents novel control policies for AP systems, affirming the great potential of proposed methods for efficient closed-loop glucose control.

This paper discusses the results for the second edition of the Monocular Depth Estimation Challenge (MDEC). This edition was open to methods using any form of supervision, including fully-supervised, self-supervised, multi-task or proxy depth. The challenge was based around the SYNS-Patches dataset, which features a wide diversity of environments with high-quality dense ground-truth. This includes complex natural environments, e.g. forests or fields, which are greatly underrepresented in current benchmarks. The challenge received eight unique submissions that outperformed the provided SotA baseline on any of the pointcloud- or image-based metrics. The top supervised submission improved relative F-Score by 27.62%, while the top self-supervised improved it by 16.61%. Supervised submissions generally leveraged large collections of datasets to improve data diversity. Self-supervised submissions instead updated the network architecture and pretrained backbones. These results represent a significant progress in the field, while highlighting avenues for future research, such as reducing interpolation artifacts at depth boundaries, improving self-supervised indoor performance and overall natural image accuracy.

Antimicrobial resistance is one of the biggest health problem, especially in the current period of COVID-19 pandemic. Due to the unique membrane-destruction bactericidal mechanism, antimicrobial peptide-mimetic copolymers are paid more attention and it is urgent to find more potential candidates with broad-spectrum antibacterial efficacy and low toxicity. Artificial intelligence has shown significant performance on small molecule or biotech drugs, however, the higher-dimension of polymer space and the limited experimental data restrict the application of existing methods on copolymer design. Herein, we develop a universal random copolymer inverse design system via multi-model copolymer representation learning, knowledge distillation and reinforcement learning. Our system realize a high-precision antimicrobial activity prediction with few-shot data by extracting various chemical information from multi-modal copolymer representations. By pre-training a scaffold-decorator generative model via knowledge distillation, copolymer space are greatly contracted to the near space of existing data for exploration. Thus, our reinforcement learning algorithm can be adaptive for customized generation on specific scaffolds and requirements on property or structures. We apply our system on collected antimicrobial peptide-mimetic copolymers data, and we discover candidate copolymers with desired properties.

In recent years, artificial intelligence has played an important role on accelerating the whole process of drug discovery. Various of molecular representation schemes of different modals (e.g. textual sequence or graph) are developed. By digitally encoding them, different chemical information can be learned through corresponding network structures. Molecular graphs and Simplified Molecular Input Line Entry System (SMILES) are popular means for molecular representation learning in current. Previous works have done attempts by combining both of them to solve the problem of specific information loss in single-modal representation on various tasks. To further fusing such multi-modal imformation, the correspondence between learned chemical feature from different representation should be considered. To realize this, we propose a novel framework of molecular joint representation learning via Multi-Modal information of SMILES and molecular Graphs, called MMSG. We improve the self-attention mechanism by introducing bond level graph representation as attention bias in Transformer to reinforce feature correspondence between multi-modal information. We further propose a Bidirectional Message Communication Graph Neural Network (BMC GNN) to strengthen the information flow aggregated from graphs for further combination. Numerous experiments on public property prediction datasets have demonstrated the effectiveness of our model.

Robust clustering of high-dimensional data is an important topic because, in many practical situations, real data sets are heavy-tailed and/or asymmetric. Moreover, traditional model-based clustering often fails for high dimensional data due to the number of free covariance parameters. A parametrization of the component scale matrices for the mixture of generalized hyperbolic distributions is proposed by including a penalty term in the likelihood constraining the parameters resulting in a flexible model for high dimensional data and a meaningful interpretation. An analytically feasible EM algorithm is developed by placing a gamma-Lasso penalty constraining the concentration matrix. The proposed methodology is investigated through simulation studies and two real data sets.

We propose a mixture of latent trait models with common slope parameters (MCLT) for model-based clustering of high-dimensional binary data, a data type for which few established methods exist. Recent work on clustering of binary data, based on a $d$-dimensional Gaussian latent variable, is extended by incorporating common factor analyzers. Accordingly, our approach facilitates a low-dimensional visual representation of the clusters. We extend the model further by the incorporation of random block effects. The dependencies in each block are taken into account through block-specific parameters that are considered to be random variables. A variational approximation to the likelihood is exploited to derive a fast algorithm for determining the model parameters. Our approach is demonstrated on real and simulated data.