To validate the second-by-second dynamics of turbines in field experiments, it is necessary to accurately reconstruct the winds going into the turbine. Current time-resolved inflow reconstruction techniques estimate wind behavior in unobserved regions using relatively simple spectral-based models of the atmosphere. Here, we develop a technique for time-resolved inflow reconstruction that is rooted in a large-eddy simulation model of the atmosphere. Our "large-eddy reconstruction" technique blends observations and atmospheric model information through a diffusion model machine learning algorithm, allowing us to generate probabilistic ensembles of reconstructions for a single 10-min observational period. Our generated inflows can be used directly by aeroelastic codes or as inflow boundary conditions in a large-eddy simulation. We verify the second-by-second reconstruction capability of our technique in three synthetic field campaigns, finding positive Pearson correlation coefficient values (0.20>r>0.85) between ground-truth and reconstructed streamwise velocity, as well as smaller positive correlation coefficient values for unobserved fields (spanwise velocity, vertical velocity, and temperature). We validate our technique in three real-world case studies by driving large-eddy simulations with reconstructed inflows and comparing to independent inflow measurements. The reconstructions are visually similar to measurements, follow desired power spectra properties, and track second-by-second behavior (0.25 > r > 0.75).

Due to costs and practical constraints, field campaigns in the atmospheric boundary layer typically only measure a fraction of the atmospheric volume of interest. Machine learning techniques have previously successfully reconstructed unobserved regions of flow in canonical fluid mechanics problems and two-dimensional geophysical flows, but these techniques have not yet been demonstrated in the three-dimensional atmospheric boundary layer. Here, we conduct a numerical analogue of a field campaign with spatially limited measurements using large-eddy simulation. We pose flow reconstruction as an inpainting problem, and reconstruct realistic samples of turbulent, three-dimensional flow with the use of a latent diffusion model. The diffusion model generates physically plausible turbulent structures on larger spatial scales, even when input observations cover less than 1% of the volume. Through a combination of qualitative visualization and quantitative assessment, we demonstrate that the diffusion model generates meaningfully diverse samples when conditioned on just one observation. These samples successfully serve as initial conditions for a large-eddy simulation code. We find that diffusion models show promise and potential for other applications for other turbulent flow reconstruction problems.

We describe an application of machine learning to the problem of predicting preterm birth. We conduct a secondary analysis on a clinical trial dataset collected by the National In- stitute of Child Health and Human Development (NICHD) while focusing our attention on predicting different classes of preterm birth. We compare three approaches for deriving predictive models: a support vector machine (SVM) approach with linear and non-linear kernels, logistic regression with different model selection along with a model based on decision rules prescribed by physician experts for prediction of preterm birth. Our approach highlights the pre-processing methods applied to handle the inherent dynamics, noise and gaps in the data and describe techniques used to handle skewed class distributions. Empirical experiments demonstrate significant improvement in predicting preterm birth compared to past work.