The online Data Quality Monitoring system (DQM) of the CMS electromagnetic calorimeter (ECAL) is a crucial operational tool that allows ECAL experts to quickly identify, localize, and diagnose a broad range of detector issues that would otherwise hinder physics-quality data taking. Although the existing ECAL DQM system has been continuously updated to respond to new problems, it remains one step behind newer and unforeseen issues. Using unsupervised deep learning, a real-time autoencoder-based anomaly detection system is developed that is able to detect ECAL anomalies unseen in past data. After accounting for spatial variations in the response of the ECAL and the temporal evolution of anomalies, the new system is able to efficiently detect anomalies while maintaining an estimated false discovery rate between $10^{-2}$ to $10^{-4}$, beating existing benchmarks by about two orders of magnitude. The real-world performance of the system is validated using anomalies found in 2018 and 2022 LHC collision data. Additionally, first results from deploying the autoencoder-based system in the CMS online DQM workflow for the ECAL barrel during Run 3 of the LHC are presented, showing its promising performance in detecting obscure issues that could have been missed in the existing DQM system.

Machine learning is an important research area in particle physics, beginning with applications to high-level physics analysis in the 1990s and 2000s, followed by an explosion of applications in particle and event identification and reconstruction in the 2010s. In this document we discuss promising future research and development areas in machine learning in particle physics with a roadmap for their implementation, software and hardware resource requirements, collaborative initiatives with the data science community, academia and industry, and training the particle physics community in data science. The main objective of the document is to connect and motivate these areas of research and development with the physics drivers of the High-Luminosity Large Hadron Collider and future neutrino experiments and identify the resource needs for their implementation. Additionally we identify areas where collaboration with external communities will be of great benefit.