Chronic kidney disease (CKD) is a major global health issue, affecting over 10% of the population and causing significant mortality. While kidney biopsy remains the gold standard for CKD diagnosis and treatment, the lack of comprehensive benchmarks for kidney pathology segmentation hinders progress in the field. To address this, we organized the Kidney Pathology Image Segmentation (KPIs) Challenge, introducing a dataset that incorporates preclinical rodent models of CKD with over 10,000 annotated glomeruli from 60+ Periodic Acid Schiff (PAS)-stained whole slide images. The challenge includes two tasks, patch-level segmentation and whole slide image segmentation and detection, evaluated using the Dice Similarity Coefficient (DSC) and F1-score. By encouraging innovative segmentation methods that adapt to diverse CKD models and tissue conditions, the KPIs Challenge aims to advance kidney pathology analysis, establish new benchmarks, and enable precise, large-scale quantification for disease research and diagnosis.

Deep neural networks, which employ batch normalization and ReLU-like activation functions, suffer from instability in the early stages of training due to the high gradient induced by temporal gradient explosion. In this study, we analyze the occurrence and mitigation of gradient explosion both theoretically and empirically, and discover that the correlation between activations plays a key role in preventing the gradient explosion from persisting throughout the training. Finally, based on our observations, we propose an improved adaptive learning rate algorithm to effectively control the training instability.