International benchmarking competitions have become fundamental for the comparative performance assessment of image analysis methods. However, little attention has been given to investigating what can be learnt from these competitions. Do they really generate scientific progress? What are common and successful participation strategies? What makes a solution superior to a competing method? To address this gap in the literature, we performed a multi-center study with all 80 competitions that were conducted in the scope of IEEE ISBI 2021 and MICCAI 2021. Statistical analyses performed based on comprehensive descriptions of the submitted algorithms linked to their rank as well as the underlying participation strategies revealed common characteristics of winning solutions. These typically include the use of multi-task learning (63%) and/or multi-stage pipelines (61%), and a focus on augmentation (100%), image preprocessing (97%), data curation (79%), and postprocessing (66%). The "typical" lead of a winning team is a computer scientist with a doctoral degree, five years of experience in biomedical image analysis, and four years of experience in deep learning. Two core general development strategies stood out for highly-ranked teams: the reflection of the metrics in the method design and the focus on analyzing and handling failure cases. According to the organizers, 43% of the winning algorithms exceeded the state of the art but only 11% completely solved the respective domain problem. The insights of our study could help researchers (1) improve algorithm development strategies when approaching new problems, and (2) focus on open research questions revealed by this work.

Surgical scene understanding is a key prerequisite for contextaware decision support in the operating room. While deep learning-based approaches have already reached or even surpassed human performance in various fields, the task of surgical action recognition remains a major challenge. With this contribution, we are the first to investigate the concept of self-distillation as a means of addressing class imbalance and potential label ambiguity in surgical video analysis. Our proposed method is a heterogeneous ensemble of three models that use Swin Transfomers as backbone and the concepts of self-distillation and multi-task learning as core design choices. According to ablation studies performed with the CholecT45 challenge data via cross-validation, the biggest performance boost is achieved by the usage of soft labels obtained by self-distillation. External validation of our method on an independent test set was achieved by providing a Docker container of our inference model to the challenge organizers. According to their analysis, our method outperforms all other solutions submitted to the latest challenge in the field. Our approach thus shows the potential of self-distillation for becoming an important tool in medical image analysis applications.

Recent advancements in deep learning methods bring computer-assistance a step closer to fulfilling promises of safer surgical procedures. However, the generalizability of such methods is often dependent on training on diverse datasets from multiple medical institutions, which is a restrictive requirement considering the sensitive nature of medical data. Recently proposed collaborative learning methods such as Federated Learning (FL) allow for training on remote datasets without the need to explicitly share data. Even so, data annotation still represents a bottleneck, particularly in medicine and surgery where clinical expertise is often required. With these constraints in mind, we propose FedCy, a federated semi-supervised learning (FSSL) method that combines FL and self-supervised learning to exploit a decentralized dataset of both labeled and unlabeled videos, thereby improving performance on the task of surgical phase recognition. By leveraging temporal patterns in the labeled data, FedCy helps guide unsupervised training on unlabeled data towards learning task-specific features for phase recognition. We demonstrate significant performance gains over state-of-the-art FSSL methods on the task of automatic recognition of surgical phases using a newly collected multi-institutional dataset of laparoscopic cholecystectomy videos. Furthermore, we demonstrate that our approach also learns more generalizable features when tested on data from an unseen domain.

Medical AI has tremendous potential to advance healthcare by supporting the evidence-based practice of medicine, personalizing patient treatment, reducing costs, and improving provider and patient experience. We argue that unlocking this potential requires a systematic way to measure the performance of medical AI models on large-scale heterogeneous data. To meet this need, we are building MedPerf, an open framework for benchmarking machine learning in the medical domain. MedPerf will enable federated evaluation in which models are securely distributed to different facilities for evaluation, thereby empowering healthcare organizations to assess and verify the performance of AI models in an efficient and human-supervised process, while prioritizing privacy. We describe the current challenges healthcare and AI communities face, the need for an open platform, the design philosophy of MedPerf, its current implementation status, and our roadmap. We call for researchers and organizations to join us in creating the MedPerf open benchmarking platform.

3-D pose estimation of instruments is a crucial step towards automatic scene understanding in robotic minimally invasive surgery. Although robotic systems can potentially directly provide joint values, this information is not commonly exploited inside the operating room, due to its possible unreliability, limited access and the time-consuming calibration required, especially for continuum robots. For this reason, standard approaches for 3-D pose estimation involve the use of external tracking systems. Recently, image-based methods have emerged as promising, non-invasive alternatives. While many image-based approaches in the literature have shown accurate results, they generally require either a complex iterative optimization for each processed image, making them unsuitable for real-time applications, or a large number of manually-annotated images for efficient learning. In this paper we propose a self-supervised image-based method, exploiting, at training time only, the imprecise kinematic information provided by the robot. In order to avoid introducing time-consuming manual annotations, the problem is formulated as an auto-encoder, smartly bottlenecked by the presence of a physical model of the robotic instruments and surgical camera, forcing a separation between image background and kinematic content. Validation of the method was performed on semi-synthetic, phantom and in-vivo datasets, obtained using a flexible robotized endoscope, showing promising results for real-time image-based 3-D pose estimation of surgical instruments.

Vision algorithms capable of interpreting scenes from a real-time video stream are necessary for computer-assisted surgery systems to achieve context-aware behavior. In laparoscopic procedures one particular algorithm needed for such systems is the identification of surgical phases, for which the current state of the art is a model based on a CNN-LSTM. A number of previous works using models of this kind have trained them in a fully supervised manner, requiring a fully annotated dataset. Instead, our work confronts the problem of learning surgical phase recognition in scenarios presenting scarce amounts of annotated data (under 25% of all available video recordings). We propose a teacher/student type of approach, where a strong predictor called the teacher, trained beforehand on a small dataset of ground truth-annotated videos, generates synthetic annotations for a larger dataset, which another model - the student - learns from. In our case, the teacher features a novel CNN-biLSTM-CRF architecture, designed for offline inference only. The student, on the other hand, is a CNN-LSTM capable of making real-time predictions. Results for various amounts of manually annotated videos demonstrate the superiority of the new CNN-biLSTM-CRF predictor as well as improved performance from the CNN-LSTM trained using synthetic labels generated for unannotated videos. For both offline and online surgical phase recognition with very few annotated recordings available, this new teacher/student strategy provides a valuable performance improvement by efficiently leveraging the unannotated data.

When used in challenging applications like surgery or underwater maintenance, the use of tele-operated robots involves manipulations that are complex to perform on the master controllers due to restricted access and limited perception. In this paper, we investigate an assistance approach for tele-robotic manipulation, in which the robot automates several degrees of freedom (DOF) of the tools, such as their orientation. This automation requires the understanding of the intent of the operator, so as to not impede the natural manipulation of the remaining DOF. Our system is therefore based on the observation that in the aforementioned applications, the manipulation tasks have often a structure that can be learned from the daily usage of the robot. We propose an approach that uses the typical motion performed by the operator during a given task, learned from demonstration, to automate the rotation of the manipulator in new instances of this task. The operator keeps control of the robot by manipulating the tool translation and can recover full control if needed. The learned motion model is based on Gaussian Mixture Regressions and combined with a 3D reconstruction of the environment to address variations in the task. We demonstrate our assistance approach using a da Vinci robot on a task consisting of moving a ring along a wire possessing a complex 3D shape.