Medical image classification is a critical problem for healthcare, with the potential to alleviate the workload of doctors and facilitate diagnoses of patients. However, two challenges arise when deploying deep learning models to real-world healthcare applications. First, neural models tend to learn spurious correlations instead of desired features, which could fall short when generalizing to new domains (e.g., patients with different ages). Second, these black-box models lack interpretability. When making diagnostic predictions, it is important to understand why a model makes a decision for trustworthy and safety considerations. In this paper, to address these two limitations, we propose a new paradigm to build robust and interpretable medical image classifiers with natural language concepts. Specifically, we first query clinical concepts from GPT-4, then transform latent image features into explicit concepts with a vision-language model. We systematically evaluate our method on eight medical image classification datasets to verify its effectiveness. On challenging datasets with strong confounding factors, our method can mitigate spurious correlations thus substantially outperform standard visual encoders and other baselines. Finally, we show how classification with a small number of concepts brings a level of interpretability for understanding model decisions through case studies in real medical data.

Pre-training models with large crawled corpora can lead to issues such as toxicity and bias, as well as copyright and privacy concerns. A promising way of alleviating such concerns is to conduct pre-training with synthetic tasks and data, since no real-world information is ingested by the model. Our goal in this paper is to understand the factors that contribute to the effectiveness of pre-training models when using synthetic resources, particularly in the context of neural machine translation. We propose several novel approaches to pre-training translation models that involve different levels of lexical and structural knowledge, including: 1) generating obfuscated data from a large parallel corpus 2) concatenating phrase pairs extracted from a small word-aligned corpus, and 3) generating synthetic parallel data without real human language corpora. Our experiments on multiple language pairs reveal that pre-training benefits can be realized even with high levels of obfuscation or purely synthetic parallel data. We hope the findings from our comprehensive empirical analysis will shed light on understanding what matters for NMT pre-training, as well as pave the way for the development of more efficient and less toxic models.

Even when aggregate accuracy is high, state-of-the-art NLP models often fail systematically on specific subgroups of data, resulting in unfair outcomes and eroding user trust. Additional data collection may not help in addressing these weaknesses, as such challenging subgroups may be unknown to users, and underrepresented in the existing and new data. We propose Targeted Data Generation (TDG), a framework that automatically identifies challenging subgroups, and generates new data for those subgroups using large language models (LLMs) with a human in the loop. TDG estimates the expected benefit and potential harm of data augmentation for each subgroup, and selects the ones most likely to improve within group performance without hurting overall performance. In our experiments, TDG significantly improves the accuracy on challenging subgroups for state-of-the-art sentiment analysis and natural language inference models, while also improving overall test accuracy.

Sharing medical reports is essential for patient-centered care. A recent line of work has focused on automatically generating reports with NLP methods. However, different audiences have different purposes when writing/reading medical reports -- for example, healthcare professionals care more about pathology, whereas patients are more concerned with the diagnosis ("Is there any abnormality?"). The expectation gap results in a common situation where patients find their medical reports to be ambiguous and therefore unsure about the next steps. In this work, we explore the audience expectation gap in healthcare and summarize common ambiguities that lead patients to be confused about their diagnosis into three categories: medical jargon, contradictory findings, and misleading grammatical errors. Based on our analysis, we define a disambiguation rewriting task to regenerate an input to be unambiguous while preserving information about the original content. We further propose a rewriting algorithm based on contrastive pretraining and perturbation-based rewriting. In addition, we create two datasets, OpenI-Annotated based on chest reports and VA-Annotated based on general medical reports, with available binary labels for ambiguity and abnormality presence annotated by radiology specialists. Experimental results on these datasets show that our proposed algorithm effectively rewrites input sentences in a less ambiguous way with high content fidelity. Our code and annotated data are released to facilitate future research.