Time series~(TS) modeling is essential in dynamic systems like weather prediction and anomaly detection. Recent studies utilize Large Language Models (LLMs) for TS modeling, leveraging their powerful pattern recognition capabilities. These methods primarily position LLMs as the predictive backbone, often omitting the mathematical modeling within traditional TS models, such as periodicity. However, disregarding the potential of LLMs also overlooks their pattern recognition capabilities. To address this gap, we introduce \textit{LLM-TS Integrator}, a novel framework that effectively integrates the capabilities of LLMs into traditional TS modeling. Central to this integration is our \textit{mutual information} module. The core of this \textit{mutual information} module is a traditional TS model enhanced with LLM-derived insights for improved predictive abilities. This enhancement is achieved by maximizing the mutual information between traditional model's TS representations and LLM's textual representation counterparts, bridging the two modalities. Moreover, we recognize that samples vary in importance for two losses: traditional prediction and mutual information maximization. To address this variability, we introduce the \textit{sample reweighting} module to improve information utilization. This module assigns dual weights to each sample: one for prediction loss and another for mutual information loss, dynamically optimizing these weights via bi-level optimization. Our method achieves state-of-the-art or comparable performance across five mainstream TS tasks, including short-term and long-term forecasting, imputation, classification, and anomaly detection.

Large language models (LLMs) have demonstrated great success in various fields, benefiting from their huge amount of parameters that store knowledge. However, LLMs still suffer from several key issues, such as hallucination problems, knowledge update issues, and lacking domain-specific expertise. The appearance of retrieval-augmented generation (RAG), which leverages an external knowledge database to augment LLMs, makes up those drawbacks of LLMs. This paper reviews all significant techniques of RAG, especially in the retriever and the retrieval fusions. Besides, tutorial codes are provided for implementing the representative techniques in RAG. This paper further discusses the RAG training, including RAG with/without datastore update. Then, we introduce the application of RAG in representative natural language processing tasks and industrial scenarios. Finally, this paper discusses the future directions and challenges of RAG for promoting its development.

Offline model-based optimization (MBO) aims to maximize a black-box objective function using only an offline dataset of designs and scores. A prevalent approach involves training a conditional generative model on existing designs and their associated scores, followed by the generation of new designs conditioned on higher target scores. However, these newly generated designs often underperform due to the lack of high-scoring training data. To address this challenge, we introduce a novel method, Design Editing for Offline Model-based Optimization (DEMO), which consists of two phases. In the first phase, termed pseudo-target distribution generation, we apply gradient ascent on the offline dataset using a trained surrogate model, producing a synthetic dataset where the predicted scores serve as new labels. A conditional diffusion model is subsequently trained on this synthetic dataset to capture a pseudo-target distribution, which enhances the accuracy of the conditional diffusion model in generating higher-scoring designs. Nevertheless, the pseudo-target distribution is susceptible to noise stemming from inaccuracies in the surrogate model, consequently predisposing the conditional diffusion model to generate suboptimal designs. We hence propose the second phase, existing design editing, to directly incorporate the high-scoring features from the offline dataset into design generation. In this phase, top designs from the offline dataset are edited by introducing noise, which are subsequently refined using the conditional diffusion model to produce high-scoring designs. Overall, high-scoring designs begin with inheriting high-scoring features from the second phase and are further refined with a more accurate conditional diffusion model in the first phase. Empirical evaluations on 7 offline MBO tasks show that DEMO outperforms various baseline methods.

Large language models (LLMs) have received considerable attention recently due to their outstanding comprehension and reasoning capabilities, leading to great progress in many fields. The advancement of LLM techniques also offers promising opportunities to automate many tasks in the telecommunication (telecom) field. After pre-training and fine-tuning, LLMs can perform diverse downstream tasks based on human instructions, paving the way to artificial general intelligence (AGI)-enabled 6G. Given the great potential of LLM technologies, this work aims to provide a comprehensive overview of LLM-enabled telecom networks. In particular, we first present LLM fundamentals, including model architecture, pre-training, fine-tuning, inference and utilization, model evaluation, and telecom deployment. Then, we introduce LLM-enabled key techniques and telecom applications in terms of generation, classification, optimization, and prediction problems. Specifically, the LLM-enabled generation applications include telecom domain knowledge, code, and network configuration generation. After that, the LLM-based classification applications involve network security, text, image, and traffic classification problems. Moreover, multiple LLM-enabled optimization techniques are introduced, such as automated reward function design for reinforcement learning and verbal reinforcement learning. Furthermore, for LLM-aided prediction problems, we discussed time-series prediction models and multi-modality prediction problems for telecom. Finally, we highlight the challenges and identify the future directions of LLM-enabled telecom networks.

Bi-level optimization, especially the gradient-based category, has been widely used in the deep learning community including hyperparameter optimization and meta-knowledge extraction. Bi-level optimization embeds one problem within another and the gradient-based category solves the outer-level task by computing the hypergradient, which is much more efficient than classical methods such as the evolutionary algorithm. In this survey, we first give a formal definition of the gradient-based bi-level optimization. Next, we delineate criteria to determine if a research problem is apt for bi-level optimization and provide a practical guide on structuring such problems into a bi-level optimization framework, a feature particularly beneficial for those new to this domain. More specifically, there are two formulations: the single-task formulation to optimize hyperparameters such as regularization parameters and the distilled data, and the multi-task formulation to extract meta-knowledge such as the model initialization. With a bi-level formulation, we then discuss four bi-level optimization solvers to update the outer variable including explicit gradient update, proxy update, implicit function update, and closed-form update. Finally, we wrap up the survey by highlighting two prospective future directions: (1) Effecctive Data Optimization for Science examined through the lens of task formulation.

Protein representation learning methods have shown great potential to yield useful representation for many downstream tasks, especially on protein classification. Moreover, a few recent studies have shown great promise in addressing insufficient labels of proteins with self-supervised learning methods. However, existing protein language models are usually pretrained on protein sequences without considering the important protein structural information. To this end, we propose a novel structure-aware protein self-supervised learning method to effectively capture structural information of proteins. In particular, a well-designed graph neural network (GNN) model is pretrained to preserve the protein structural information with self-supervised tasks from a pairwise residue distance perspective and a dihedral angle perspective, respectively. Furthermore, we propose to leverage the available protein language model pretrained on protein sequences to enhance the self-supervised learning. Specifically, we identify the relation between the sequential information in the protein language model and the structural information in the specially designed GNN model via a novel pseudo bi-level optimization scheme. Experiments on several supervised downstream tasks verify the effectiveness of our proposed method.The code of the proposed method is available in \url{https://github.com/GGchen1997/STEPS_Bioinformatics}.

Feature selection is a powerful dimension reduction technique which selects a subset of relevant features for model construction. Numerous feature selection methods have been proposed, but most of them fail under the high-dimensional and low-sample size (HDLSS) setting due to the challenge of overfitting. In this paper, we present a deep learning-based method - GRAph Convolutional nEtwork feature Selector (GRACES) - to select important features for HDLSS data. We demonstrate empirical evidence that GRACES outperforms other feature selection methods on both synthetic and real-world datasets.

As a natural extension of link prediction on graphs, hyperlink prediction aims for the inference of missing hyperlinks in hypergraphs, where a hyperlink can connect more than two nodes. Hyperlink prediction has applications in a wide range of systems, from chemical reaction networks, social communication networks, to protein-protein interaction networks. In this paper, we provide a systematic and comprehensive survey on hyperlink prediction. We propose a new taxonomy to classify existing hyperlink prediction methods into four categories: similarity-based, probability-based, matrix optimization-based, and deep learning-based methods. To compare the performance of methods from different categories, we perform a benchmark study on various hypergraph applications using representative methods from each category. Notably, deep learning-based methods prevail over other methods in hyperlink prediction.