In advancing the understanding of decision-making processes, Inverse Reinforcement Learning (IRL) have proven instrumental in reconstructing animal's multiple intentions amidst complex behaviors. Given the recent development of a continuous-time multi-intention IRL framework, there has been persistent inquiry into inferring discrete time-varying rewards with IRL. To tackle the challenge, we introduce Latent (Markov) Variable Inverse Q-learning (L(M)V-IQL), a novel class of IRL algorthms tailored for accommodating discrete intrinsic reward functions. Leveraging an Expectation-Maximization approach, we cluster observed expert trajectories into distinct intentions and independently solve the IRL problem for each. Demonstrating the efficacy of L(M)V-IQL through simulated experiments and its application to different real mouse behavior datasets, our approach surpasses current benchmarks in animal behavior prediction, producing interpretable reward functions. This advancement holds promise for neuroscience and cognitive science, contributing to a deeper understanding of decision-making and uncovering underlying brain mechanisms.

Reinforcement learning (RL) is recognized as lacking generalization and robustness under environmental perturbations, which excessively restricts its application for real-world robotics. Prior work claimed that adding regularization to the value function is equivalent to learning a robust policy with uncertain transitions. Although the regularization-robustness transformation is appealing for its simplicity and efficiency, it is still lacking in continuous control tasks. In this paper, we propose a new regularizer named $\textbf{U}$ncertainty $\textbf{S}$et $\textbf{R}$egularizer (USR), by formulating the uncertainty set on the parameter space of the transition function. In particular, USR is flexible enough to be plugged into any existing RL framework. To deal with unknown uncertainty sets, we further propose a novel adversarial approach to generate them based on the value function. We evaluate USR on the Real-world Reinforcement Learning (RWRL) benchmark, demonstrating improvements in the robust performance for perturbed testing environments.

In recent years, several unsupervised cell segmentation methods have been presented, trying to omit the requirement of laborious pixel-level annotations for the training of a cell segmentation model. Most if not all of these methods handle the instance segmentation task by focusing on the detection of different cell instances ignoring their type. While such models prove adequate for certain tasks, like cell counting, other applications require the identification of each cell's type. In this paper, we present CellMixer, an innovative annotation-free approach for the semantic segmentation of heterogeneous cell populations. Our augmentation-based method enables the training of a segmentation model from image-level labels of homogeneous cell populations. Our results show that CellMixer can achieve competitive segmentation performance across multiple cell types and imaging modalities, demonstrating the method's scalability and potential for broader applications in medical imaging, cellular biology, and diagnostics.

The field of antibody-based therapeutics has grown significantly in recent years, with targeted antibodies emerging as a potentially effective approach to personalized therapies. Such therapies could be particularly beneficial for complex, highly individual diseases such as cancer. However, progress in this field is often constrained by the extensive search space of amino acid sequences that form the foundation of antibody design. In this study, we introduce a novel reinforcement learning method specifically tailored to address the unique challenges of this domain. We demonstrate that our method can learn the design of high-affinity antibodies against multiple targets in silico, utilizing either online interaction or offline datasets. To the best of our knowledge, our approach is the first of its kind and outperforms existing methods on all tested antigens in the Absolut!

Flexible robots may overcome some of the industry's major challenges, such as enabling intrinsically safe human-robot collaboration and achieving a higher load-to-mass ratio. However, controlling flexible robots is complicated due to their complex dynamics, which include oscillatory behavior and a high-dimensional state space. NMPC offers an effective means to control such robots, but its extensive computational demands often limit its application in real-time scenarios. To enable fast control of flexible robots, we propose a framework for a safe approximation of NMPC using imitation learning and a predictive safety filter. Our framework significantly reduces computation time while incurring a slight loss in performance. Compared to NMPC, our framework shows more than a eightfold improvement in computation time when controlling a three-dimensional flexible robot arm in simulation, all while guaranteeing safety constraints. Notably, our approach outperforms conventional reinforcement learning methods. The development of fast and safe approximate NMPC holds the potential to accelerate the adoption of flexible robots in industry.

The brain's biological age has been considered as a promising candidate for a neurologically significant biomarker. However, recent results based on longitudinal magnetic resonance imaging data have raised questions on its interpretation. A central question is whether an increased biological age of the brain is indicative of brain pathology and if changes in brain age correlate with diagnosed pathology (state hypothesis). Alternatively, could the discrepancy in brain age be a stable characteristic unique to each individual (trait hypothesis)? To address this question, we present a comprehensive study on brain aging based on clinical EEG, which is complementary to previous MRI-based investigations. We apply a state-of-the-art Temporal Convolutional Network (TCN) to the task of age regression. We train on recordings of the Temple University Hospital EEG Corpus (TUEG) explicitly labeled as non-pathological and evaluate on recordings of subjects with non-pathological as well as pathological recordings, both with examinations at a single point in time and repeated examinations over time. Therefore, we created four novel subsets of TUEG that include subjects with multiple recordings: I) all labeled non-pathological; II) all labeled pathological; III) at least one recording labeled non-pathological followed by at least one recording labeled pathological; IV) similar to III) but with opposing transition (first pathological then non-pathological). The results show that our TCN reaches state-of-the-art performance in age decoding with a mean absolute error of 6.6 years. Our extensive analyses demonstrate that the model significantly underestimates the age of non-pathological and pathological subjects (-1 and -5 years, paired t-test, p <= 0.18 and p <= 0.0066). Furthermore, the brain age gap biomarker is not indicative of pathological EEG.

In policy learning for robotic manipulation, sample efficiency is of paramount importance. Thus, learning and extracting more compact representations from camera observations is a promising avenue. However, current methods often assume full observability of the scene and struggle with scale invariance. In many tasks and settings, this assumption does not hold as objects in the scene are often occluded or lie outside the field of view of the camera, rendering the camera observation ambiguous with regard to their location. To tackle this problem, we present BASK, a Bayesian approach to tracking scale-invariant keypoints over time. Our approach successfully resolves inherent ambiguities in images, enabling keypoint tracking on symmetrical objects and occluded and out-of-view objects. We employ our method to learn challenging multi-object robot manipulation tasks from wrist camera observations and demonstrate superior utility for policy learning compared to other representation learning techniques. Furthermore, we show outstanding robustness towards disturbances such as clutter, occlusions, and noisy depth measurements, as well as generalization to unseen objects both in simulation and real-world robotic experiments.

In autonomous navigation settings, several quantities can be subject to variations. Terrain properties such as friction coefficients may vary over time depending on the location of the robot. Also, the dynamics of the robot may change due to, e.g., different payloads, changing the system's mass, or wear and tear, changing actuator gains or joint friction. An autonomous agent should thus be able to adapt to such variations. In this paper, we develop a novel probabilistic, terrain- and robot-aware forward dynamics model, termed TRADYN, which is able to adapt to the above-mentioned variations. It builds on recent advances in meta-learning forward dynamics models based on Neural Processes. We evaluate our method in a simulated 2D navigation setting with a unicycle-like robot and different terrain layouts with spatially varying friction coefficients. In our experiments, the proposed model exhibits lower prediction error for the task of long-horizon trajectory prediction, compared to non-adaptive ablation models. We also evaluate our model on the downstream task of navigation planning, which demonstrates improved performance in planning control-efficient paths by taking robot and terrain properties into account.

Geometric regularity, which leverages data symmetry, has been successfully incorporated into deep learning architectures such as CNNs, RNNs, GNNs, and Transformers. While this concept has been widely applied in robotics to address the curse of dimensionality when learning from high-dimensional data, the inherent reflectional and rotational symmetry of robot structures has not been adequately explored. Drawing inspiration from cooperative multi-agent reinforcement learning, we introduce novel network structures for deep learning algorithms that explicitly capture this geometric regularity. Moreover, we investigate the relationship between the geometric prior and the concept of Parameter Sharing in multi-agent reinforcement learning. Through experiments conducted on various challenging continuous control tasks, we demonstrate the significant potential of the proposed geometric regularity in enhancing robot learning capabilities.

Autonomous vehicles rely on a variety of sensors to gather information about their surrounding. The vehicle's behavior is planned based on the environment perception, making its reliability crucial for safety reasons. The active LiDAR sensor is able to create an accurate 3D representation of a scene, making it a valuable addition for environment perception for autonomous vehicles. Due to light scattering and occlusion, the LiDAR's performance change under adverse weather conditions like fog, snow or rain. This limitation recently fostered a large body of research on approaches to alleviate the decrease in perception performance. In this survey, we gathered, analyzed, and discussed different aspects on dealing with adverse weather conditions in LiDAR-based environment perception. We address topics such as the availability of appropriate data, raw point cloud processing and denoising, robust perception algorithms and sensor fusion to mitigate adverse weather induced shortcomings. We furthermore identify the most pressing gaps in the current literature and pinpoint promising research directions.