Multiscale Semi-Markov Dynamics for Intracortical Brain-Computer Interfaces

Intracortical brain-computer interfaces (iBCIs) have allowed people with tetraplegia to control a computer cursor by imagining the movement of their paralyzed arm or hand. State-of-the-art decoders deployed in human iBCIs are derived from a Kalman filter that assumes Markov dynamics on the angle of intended movement, and a unimodal dependence on intended angle for each channel of neural activity. Due to errors made in the decoding of noisy neural data, as a user attempts to move the cursor to a goal, the angle between cursor and goal positions may change rapidly. We propose a dynamic Bayesian network that includes the on-screen goal position as part of its latent state, and thus allows the person's intended angle of movement to be aggregated over a much longer history of neural activity. This multiscale model explicitly captures the relationship between instantaneous angles of motion and long-term goals, and incorporates semi-Markov dynamics for motion trajectories.