Diabetes management is a difficult task for patients, who must monitor and control their blood glucose levels in order to avoid serious diabetic complications. This paper describes three emerging applications that employ AI to ease this task: (1) case-based decision support for diabetes management; (2) machine learning classification of blood glucose plots; and (3) support vector regression for blood glucose prediction. The first application provides decision support by detecting blood glucose control problems and recommending therapeutic adjustments to correct them. The third aims to build a hypoglycemia predictor that could alert patients to dangerously low blood glucose levels in time to take preventive action.

In this article we provide insight into the BodyMedia FIT armband system -- a wearable multi-sensor technology that continuously monitors physiological events related to energy expenditure for weight management using machine learning and data modeling methods. Since becoming commercially available in 2001, more than half a million users have used the system to track their physiological parameters and to achieve their individual health goals including weight-loss. We describe several challenges that arise in applying machine learning techniques to the health care domain and present various solutions utilized in the armband system. We demonstrate how machine learning and multi-sensor data fusion techniques are critical to the system's success.

This article introduces the challenge of digital preservation in the area of engineering design and manufacturing and presents a methodology to apply knowledge representation and semantic techniques to develop Digital Engineering Archives. This work is part of an ongoing, multiuniversity, effort to create cyber infrastructure-based engineering repositories for undergraduates (CIBER-U) to support engineering design education. The technical approach is to use knowledge representation techniques to create formal models of engineering data elements, workflows and processes. With these formal engineering knowledge and processes can be captured and preserved with some guarantee of long-term interpretability.

Within computational biology, algorithms are constructed with the aim of extracting knowledge from biological data, in particular, data generated by the large genome projects, where gene and protein sequences are produced in high volume. In this article, we explore new ways of representing protein-sequence information, using machine learning strategies, where the primary goal is the discovery of novel powerful representations for use in AI techniques. In the case of proteins and the 20 different amino acids they typically contain, it is also a secondary goal to discover how the current selection of amino acids -- which now are common in proteins -- might have emerged from simpler selections, or alphabets, in use earlier during the evolution of living organisms.

My dissertation concerns the application of constraint-based reasoning to parametric engineering design (Murtagh 1991).1 It deals with the practical application of constraint networks, using automated reasoning to overcome some of the blind spots in conventional iterative design.