Human emotions unfold over time, and more affective computing research has to prioritize capturing this crucial component of real-world affect. Modeling dynamic emotional stimuli requires solving the twin challenges of time-series modeling and of collecting high-quality time-series datasets. We begin by assessing the state-of-the-art in time-series emotion recognition, and we review contemporary time-series approaches in affective computing, including discriminative and generative models. We then introduce the first version of the Stanford Emotional Narratives Dataset (SENDv1): a set of rich, multimodal videos of self-paced, unscripted emotional narratives, annotated for emotional valence over time. The complex narratives and naturalistic expressions in this dataset provide a challenging test for contemporary time-series emotion recognition models. We demonstrate several baseline and state-of-the-art modeling approaches on the SEND, including a Long Short-Term Memory model and a multimodal Variational Recurrent Neural Network, which perform comparably to the human-benchmark. We end by discussing the implications for future research in time-series affective computing.

Certain research strands can yield "forbidden knowledge". This term refers to knowledge that is considered too sensitive, dangerous or taboo to be produced or shared. Discourses about such publication restrictions are already entrenched in scientific fields like IT security, synthetic biology or nuclear physics research. This paper makes the case for transferring this discourse to machine learning research. Some machine learning applications can very easily be misused and unfold harmful consequences, for instance with regard to generative video or text synthesis, personality analysis, behavior manipulation, software vulnerability detection and the like. Up to now, the machine learning research community embraces the idea of open access. However, this is opposed to precautionary efforts to prevent the malicious use of machine learning applications. Information about or from such applications may, if improperly disclosed, cause harm to people, organizations or whole societies. Hence, the goal of this work is to outline norms that can help to decide whether and when the dissemination of such information should be prevented. It proposes review parameters for the machine learning community to establish an ethical framework on how to deal with forbidden knowledge and dual-use applications.

Prec ision Medicine (PM) is an emerging approach that appears with the impression of changing the existing paradigm of medical practice. Recent advances in technological innovations and genetics, and the growing availability of health data have set a new pace o f the research and imposes a set of new requirements on different stakeholders. To date, some studies are available that discuss about different aspects of PM. Nevertheless, a holistic representation of those aspects deemed to confer the technological pers pective, in relation to applications and challenges, is mostly ignored. In this context, this paper surveys advances in PM from informatics viewpoint and reviews the enabling tools and techniques in a categorized manner. In addition, the study discusses ho w other technological paradigms including big data, artificial intelligence, and internet of things can be exploited to advance the potentials of PM. Furthermore, the paper provides some guidelines for future research for seamless implementation and wide - s cale deployment of PM based on identified open issues and associated challenges. To this end, the paper proposes an integrated holistic framework for PM motivating informatics researchers to design their relevant research works in an appropriate context.

The importance of automated Facial Emotion Recognition (FER) grows the more common human-machine interactions become, which will only continue to increase dramatically with time. A common method to describe human sentiment or feeling is the categorical model the `7 basic emotions', consisting of `Angry', `Disgust', `Fear', `Happiness', `Sadness', `Surprise' and `Neutral'. The `Emotion Recognition in the Wild' (EmotiW) competition is now in its 7th year and has become the standard benchmark for measuring FER performance. The focus of this paper is the EmotiW sub-challenge of classifying videos in the `Acted Facial Expression in the Wild' (AFEW) dataset, consisting of both visual and audio modalities, into one of the above classes. Machine learning has exploded as a research topic in recent years, with advancements in `Deep Learning' a key part of this. Although Deep Learning techniques have been widely applied to the FER task by entrants in previous years, this paper has two main contributions: (i) to apply the latest `state-of-the-art' visual and temporal networks and (ii) exploring various methods of fusing features extracted from the visual and audio elements to enrich the information available to the final model making the prediction. There are a number of complex issues that arise when trying to classify emotions for `in-the-wild' video sequences, which the above two approaches attempt to directly address. There are some positive findings when comparing the results of this paper to past submissions, indicating that further research into the proposed methods and fine-tuning of the models deployed, could result in another step forwards in the field of automated FER.

Graphs and networks are a standard model for describing data or systems based on pairwise interactions. Oftentimes, the underlying relationships involve more than two entities at a time, and hypergraphs are a more faithful model. However, we have fewer rigorous methods that can provide insight from such representations. Here, we develop a computational framework for the problem of clustering hypergraphs with categorical edge labels --- or different interaction types --- where clusters corresponds to groups of nodes that frequently participate in the same type of interaction. Our methodology is based on a combinatorial objective function that is related to correlation clustering but enables the design of much more efficient algorithms. When there are only two label types, our objective can be optimized in polynomial time, using an algorithm based on minimum cuts. Minimizing our objective becomes NP-hard with more than two label types, but we develop fast approximation algorithms based on linear programming relaxations that have theoretical cluster quality guarantees. We demonstrate the efficacy of our algorithms and the scope of the model through problems in edge-label community detection, clustering with temporal data, and exploratory data analysis.

In the last years, Artificial Intelligence (AI) has achieved a notable momentum that may deliver the best of expectations over many application sectors across the field. For this to occur, the entire community stands in front of the barrier of explainability, an inherent problem of AI techniques brought by sub-symbolism (e.g. ensembles or Deep Neural Networks) that were not present in the last hype of AI. Paradigms underlying this problem fall within the so-called eXplainable AI (XAI) field, which is acknowledged as a crucial feature for the practical deployment of AI models. This overview examines the existing literature in the field of XAI, including a prospect toward what is yet to be reached. We summarize previous efforts to define explainability in Machine Learning, establishing a novel definition that covers prior conceptual propositions with a major focus on the audience for which explainability is sought. We then propose and discuss about a taxonomy of recent contributions related to the explainability of different Machine Learning models, including those aimed at Deep Learning methods for which a second taxonomy is built. This literature analysis serves as the background for a series of challenges faced by XAI, such as the crossroads between data fusion and explainability. Our prospects lead toward the concept of Responsible Artificial Intelligence, namely, a methodology for the large-scale implementation of AI methods in real organizations with fairness, model explainability and accountability at its core. Our ultimate goal is to provide newcomers to XAI with a reference material in order to stimulate future research advances, but also to encourage experts and professionals from other disciplines to embrace the benefits of AI in their activity sectors, without any prior bias for its lack of interpretability.

Our research aims to develop interactive, social agents that can coach people to learn new tasks, skills, and habits. In this paper, we focus on coaching sedentary, overweight individuals (i.e., trainees) to exercise regularly. We employ adaptive goal setting in which the intelligent health coach generates, tracks, and revises personalized exercise goals for a trainee. The goals become incrementally more difficult as the trainee progresses through the training program. Our approach is model-based - the coach maintains a parameterized model of the trainee's aerobic capability that drives its expectation of the trainee's performance. The model is continually revised based on trainee-coach interactions. The coach is embodied in a smartphone application, NutriWalking, which serves as a medium for coach-trainee interaction. We adopt a task-centric evaluation approach for studying the utility of the proposed algorithm in promoting regular aerobic exercise. We show that our approach can adapt the trainee program not only to several trainees with different capabilities, but also to how a trainee's capability improves as they begin to exercise more. Experts rate the goals selected by the coach better than other plausible goals, demonstrating that our approach is consistent with clinical recommendations. Further, in a 6-week observational study with sedentary participants, we show that the proposed approach helps increase exercise volume performed each week.

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Road transportation is of critical importance for a nation, having profound effects in the economy, the health and life style of its people. With the growth of cities and populations come bigger demands for mobility and safety, creating new problems and magnifying those of the past. New tools are needed to face the challenge, to keep roads in good conditions, their users safe, and minimize the impact on the environment. This dissertation is concerned with road quality assessment and aggressive driving, two important problems in road transportation, approached in the context of Intelligent Transportation Systems by using Machine Learning techniques to analyze acceleration time series acquired with smartphone-based opportunistic sensing to automatically detect, classify, and characterize events of interest. Two aspects of road quality assessment are addressed: the detection and the characterization of road anomalies. For the first, the most widely cited works in the literature are compared and proposals capable of equal or better performance are presented, removing the reliance on threshold values and reducing the computational cost and dimensionality of previous proposals. For the second, new approaches for the estimation of pothole depth and the functional condition of speed reducers are showed. The new problem of pothole depth ranking is introduced, using a learning-to-rank approach to sort acceleration signals by the depth of the potholes that they reflect. The classification of aggressive driving maneuvers is done with automatic feature extraction, finding characteristically shaped subsequences in the signals as more effective discriminants than conventional descriptors calculated over time windows. Finally, all the previously mentioned tasks are combined to produce a robust road transport evaluation platform.

Activity and motion analysis has the potential to be used as a diagnostic tool for mental disorders. However, to-date, little work has been performed in turning stratification measures of activity into useful symptom markers. The research presented in this thesis has focused on the identification of objective activity and behaviour metrics that could be useful for the analysis of mental health symptoms in the above mentioned dimensions. Particular attention is given to the analysis of objective differences between disorders, as well as identification of clinical episodes of mania and depression in bipolar patients, and deterioration in borderline personality disorder patients. A principled framework is proposed for mHealth monitoring of psychiatric patients, based on measurable changes in behaviour, represented in physical activity time series, collected via mobile and wearable devices. The framework defines methods for direct computational analysis of symptoms in disorganisation and psychomotor dimensions, as well as measures for indirect assessment of mood, using patterns of physical activity, sleep and circadian rhythms. The approach of computational behaviour analysis, proposed in this thesis, has the potential for early identification of clinical deterioration in ambulatory patients, and allows for the specification of distinct and measurable behavioural phenotypes, thus enabling better understanding and treatment of mental disorders.