We have mathematically shown that cortical maps in the primary sensory cortices can be reproduced by using three hypotheses which have physiological basis and meaning. Here, our main focus is on ocular.dominance

The weakly electric fish, Gnathonemus peters;;, explores its environment by generating pulsed elecbic fields and detecting small pertwbations in the fields resulting from nearby objects. Accordingly, the fISh detects and discriminates objects on the basis of a sequence of elecbic "images" whose temporal and spatial properties depend on the timing of the fish's electric organ discharge and its body position relative to objects in its environmenl We are interested in investigating how these fish utilize timing and body-position during exploration to aid in object discrimination. We have developed a fmite-element simulation of the fish's self-generated electric fields so as to reconstruct the electrosensory consequences of body position and electric organ discharge timing in the fish. This paper describes this finite-element simulation system and presents preliminary electric field measurements which are being used to tune the simulation.

We have tested this assumption in the hippocampus, a cortical structure or the brain that is involved in long-term memory. A brier, high-frequency activation or excitatory synapses in the hippocampus produces an increase in synaptic strength known as long-term potentiation, or L TP (BUss and Lomo, 1973), that can last ror many days. LTP is known to be Hebbian since it requires the simultaneous release or neurotransmitter from presynaptic terminals coupled with postsynaptic depolarization (Kelso et al, 1986; Malinow and Miller, 1986; Gustatrson et al, 1987). However, a mechanism ror the persistent reduction or synaptic strength that could balance LTP has not yet been demonstrated. We studied the associative interactions between separate inputs onto the same dendritic trees or hippocampal pyramidal cells or field CAl, and round that a low-frequency input which, by itselr, does not persistently change synaptic strength, can either increase (associative L TP) or decrease in strength (associative long-term depression or LTD) depending upon whether it is positively or negatively correlated in time with a second, high-frequency bursting input. LTP or synaptic strength is Hebbian, and LTD is anti-Hebbian since it is elicited by pairing presynaptic firing with postsynaptic hyperpolarization sufficient to block postsynaptic activity.

We have used analog VLSI technology to model a class of small oscillating biological neural circuits known as central pattern generators (CPG). These circuits generate rhythmic patterns of activity which drive locomotor behaviour in the animal. We have designed, fabricated, and tested a model neuron circuit which relies on many of the same mechanisms as a biological central pattern generator neuron, such as delays and internal feedback. We show that this neuron can be used to build several small circuits based on known biological CPG circuits, and that these circuits produce patterns of output which are very similar to the observed biological patterns. To date, researchers in applied neural networks have tended to focus on mammalian systems as the primary source of potentially useful biological information. However, invertebrate systems may represent a source of ideas in many ways more appropriate, given current levels of engineering sophistication in building neural-like systems, and given the state of biological understanding of mammalian circuits.

This paper describes an ongoing effort which approaches neural net research in a program of close collaboration of neurosc i ent i sts and eng i neers. The effort is des i gned to elucidate associative learning in the marine snail Hermissenda crassicornist in which Pavlovian conditioning has been observed. Learning has been isolated in the four neuron network at the convergence of the v i sua 1 and vestibular pathways in this animal t and biophysical changes t specific to learning t have been observed in the membrane of the photoreceptor B cell. A basic charging capacitance model of a neuron is used and enhanced with biologically plausible mechanisms that are necessary to replicate the effect of learning at the cellular level. These mechanisms are nonlinear and are t primarilYt instances of second order control systems (e.g.

We present a new hypothesis that the cerebellum plays a key role in actively controlling the acquisition of sensory infonnation by the nervous system. In this paper we explore this idea by examining the function of a simple cerebellar-related behavior, the vestibula-ocular reflex or VOR, in which eye movements are generated to minimize image slip on the retina during rapid head movements. Considering this system from the point of view of statistical estimation theory, our results suggest that the transfer function of the VOR, often regarded as a static or slowly modifiable feature of the system, should actually be continuously and rapidly changed during head movements. We further suggest that these changes are under the direct control of the cerebellar cortex and propose experiments to test this hypothesis.

A mathematical model based on the bulbar anatomy and electrophysiology is described. Simulations produce a 35-60 Hz modulated activity coherent across the bulb, mimicing the observed field potentials. The decision states (for the odor information) here can be thought of as stable cycles, rather than point stable states typical of simpler neuro-computing models. Analysis and simulations show that a group of coupled nonlinear oscillators are responsible for the oscillatory activities determined by the odor input, and that the bulb, with appropriate inputs from higher centers, can enhance or suppress the sensitivity to partiCUlar odors. The model provides a framework in which to understand the transform between odor input and the bulbar output to olfactory cortex.

In the developing visual system in many mammalian species, there is initially a uniform, overlapping innervation of layer 4 of the visual cortex by inputs representing the two eyes. Subsequently, these inputs segregate into patches or stripes that are largely or exclusively innervated by inputs serving a single eye, known as ocular dominance patches. The ocular dominance patches are on a small scale compared to the map of the visual world, so that the initially continuous map becomes two interdigitated maps, one representing each eye. These patches, together with the layers of cortex above and below layer 4, whose responses are dominated by the eye innervating the corresponding layer 4 patch, are known as ocular dominance columns.

The bam owl has fused visual/auditory/motor representations of space in its midbrain which are used to orient the head so that visual or auditory stimuli are centered in the visual field of view.

K. Y. Goldberg and B. A. Pearlmutter School of Computer Science Carnegie Mellon University Pittsburgh, PA 15213 ABSTRACT Computing the inverse dynamics of a robot ann is an active area of research in the control literature. We hope to learn the inverse dynamics by training a neural network on the measured response of a physical ann. The input to the network is a temporal window of measured positions; output is a vector of torques. We train the network on data measured from the first two joints of the CMU Direct-Drive Arm II as it moves through a randomly-generated sample of "pick-and-place" trajectories. We then test generalization with a new trajectory and compare its output with the torque measured at the physical arm.