" The author wishes to thank Eileen Fitzpatrick for her helpful suggestions.

Retrospective on lessons learned from the Dendral project."The DENDRAL and Meta-DENDRAL programs are products of a large, interdisciplinary group of Stanford University scientists concerned with many and highly varied aspects of the mechanization of scientific reasoning and the formalization of scientific knowledge for this purpose. An early motivation for our wok was to explore the power of existing Al methods, such as heuristic search, for reasoning in difficult scientific problems. Another concern has been to exploit the AI methodology to understand better some fundamental questions in the philosophy of science, for example the processes by which explanatory hypotheses are discovered or judged adequate. From the start, the project has had an applications dimension. It has sought to develop "expert level" agents to assist in the solution of problems in their discipline that require complex symbolic reasoning. The applications dimension is the focus of this paper."Artificial Intelligence 11 (1-2): 5-24

It is essentially a Horn clause theorem prover augmented with a special inference rule for'dealing with

Tech. Rep. 118, Dept. of Computer Science, University of Toronto.

SU/X and SU/P are knowledge-based programs which employ pattern-invoked inference methods. Both tasks are concerned with the interpretation of large quantities of digitized signal data. The task of SU/X is to understand "continuous signals", that is, signals which persist over time. The task of SU/P is to interpret protein x-ray crystallographic data. Some features of the design are: (1) incremental interpretation of data employing many different pattern-invoked sources of knowledge, (2) production rule representation of knowledge, including high level strategy knowledge, (3) "opportunistic" hypothesis formation using both data-driven and model-driven techniques within a general hypothesize-and-test paradigm; and (4) multilevel representation of the solution hypothesis.

Optimal decision table conversion has been tackled in the literature using two approaches, dynamic programming and branch-and-bound. The former technique is quite effective, but its time and space requirements are independent of how "easy" the given table is. Furthermore, it cannot be used to produce good, quasioptimal solutions. The branch-and-bound technique uses a good heuristic to direct the search, but is cluttered up by an enormous search space, since the number of solutions increases with the number of test variables according to a double exponential. In this paper we suggest a heuristically guided top-down search algorithm which, like dynamic programming, recognizes identical subproblems but which can be used to find both optimal and quasioptimal solutions. The heuristic search method introduced in this paper combines the positive aspects of the above two techniques.

Aspects of an intelligent interface that provides natural language access to a large body of data distributed over a computer network are described. The overall system architecture is presented, showing how a user is buffered from the actual database management systems (DBMSs) by three layers of insulating components. These layers operate in series to convert natural language queries into calls to DBMSs at remote sites. Attention is then focused on the first of the insulating components, the natural language system. A pragmatic approach to language access that has proved useful for building interfaces to databases is described and illustrated by examples.

"Computing can change our ways of thinking about many things, mathematics, biology, engineering, administrative procedures, and many more. But my main concern is that it can change our thinking about ourselves: giving us new models, metaphors, and other thinking tools to aid our efforts to fathom the mysteries of the human mind and heart. The new discipline of Artificial Intelligence is the branch of computing most directly concerned with this revolution. By giving us new, deeper, insights into some of our inner processes, it changes our thinking about ourselves. It therefore changes some of our inner processes, and so changes what we are, like all social, technological and intellectual revolutions." This book, published in 1978 by Harvester Press and Humanities Press, has been out of print for many years, and is now online, produced from a scanned in copy of the original, digitised by OCR software and made available in September 2001. Since then a number of notes and corrections have been added. Atlantic Highlands, NJ: Humanities Press.

For example, lnterlisp permits accessing the control stack at an unusually detailed level.

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