Signal processing and classification algorithms often have limited applicability resulting from an inaccurate model of the signal's underlying structure. We present here an efficient, Bayesian algorithm for modeling a signal composed of the superposition of brief, Poisson-distributed functions. This methodology is applied to the specific problem of modeling and classifying extracellular neural waveforms which are composed of a superposition of an unknown number of action potentials CAPs). Previous approaches have had limited success due largely to the problems of determining the spike shapes, deciding how many are shapes distinct, and decomposing overlapping APs. A Bayesian solution to each of these problems is obtained by inferring a probabilistic model of the waveform. This approach quantifies the uncertainty of the form and number of the inferred AP shapes and is used to obtain an efficient method for decomposing complex overlaps. This algorithm can extract many times more information than previous methods and facilitates the extracellular investigation of neuronal classes and of interactions within neuronal circuits.

In an effort to understand saccadic eye movements and their relation to visual attention and other forms of eye movements, we - in collaboration with a number of other laboratories - are carrying out a large-scale effort to design and build a complete primate oculomotor system using analog CMOS VLSI technology. Using this technology, a low power, compact, multi-chip system has been built which works in real-time using real-world visual inputs. We describe in this paper the performance of an early version of such a system including a 1-D array of photoreceptors mimicking the retina, a circuit computing the mean location of activity representing the superior colliculus, a saccadic burst generator, and a one degree-of-freedom rotational platform which models the dynamic properties of the primate oculomotor plant. 1 Introduction When we look around our environment, we move our eyes to center and stabilize objects of interest onto our fovea. In order to achieve this, our eyes move in quick jumps with short pauses in between. These quick jumps (up to 750 deg/sec in humans) are known as saccades and are seen in both exploratory eye movements and as reflexive eye movements in response to sudden visual, auditory, or somatosensory stimuli. Since the intent of the saccade is to bring new objects of interest onto the fovea, it can be considered a primitive attentional mechanism.

The most prominent feature of this network is the pair of large Mauthner cells whose axons cross the midline and descend down the spinal cord to synapse on primary motoneurons. The Mauthner system also includes inhibitory neurons, the PHP cells, which have a unique and intense field effect inhibition at the spikeinitiating zone of the Mauthner cells (Faber and Korn, 1978). The Mauthner system is part of the full brainstem escape network which also includes two pairs of cells homologous to the Mauthner cell and other populations of reticulospinal neurons. With this network fish initiate escapes only from appropriate stimuli, turn away from the offending stimulus, and do so very rapidly with a latency around 15 msec in goldfish. The Mauthner cells play an important role in these functions.

The fovea of a mammal retina was simulated with its detailed biological properties to study the local preprocessing of images. The direct visual pathway (photoreceptors, bipolar and ganglion cells) and the horizontal units, as well as the D-amacrine cells were simulated.

Maps of orientation preference and ocular dominance were recorded optically from the cortices of 5 infant macaque monkeys, ranging in age from 3.5 to 14 weeks. In agreement with previous observations, we found that basic features of orientation and ocular dominance maps, as well as correlations between them, are present and robust by 3.5 weeks of age. We did observe changes in the strength of ocular dominance signals, as well as in the spacing of ocular dominance bands, both of which increased steadily between 3.5 and 14 weeks of age. The latter finding suggests that the adult spacing of ocular dominance bands depends on cortical growth in neonatal animals. Since we found no corresponding increase in the spacing of orientation preferences, however, there is a possibility that the orientation preferences of some cells change as the cortical surface expands. Since correlations between the patterns of orientation selectivity and ocular dominance are present at an age, when the visual system is still immature, it seems more likely that their development may be an innate process and may not require extensive visual experience.

Based on precise anatomical data of the bee's olfactory system, we propose an investigation of the possible mechanisms of modulation and control between the two levels of olfactory information processing: the antennallobe glomeruli and the mushroom bodies. We use simplified neurons, but realistic architecture. As a first conclusion, we postulate that the feature extraction performed by the antennallobe (glomeruli and interneurons) necessitates central input from the mushroom bodies for fine tuning.

About half the pyramidal neurons in layer 5 of neocortex have long apical dendrites that arborize extensively in layers 1-3. There the dendrites receive synaptic input from the inter-areal feedback projections (Felleman and van Essen, 1991) that play an important role in many models of brain function (Rockland and Virga, 1989). At first sight this seems to be an unsatisfactory arrangement. In light of traditional passive models of dendritic function the distant inputs cannot have a significant effect on the output discharge of the pyramidal cell. The distal inputs are at least one to two space constants removed from the soma in layer 5 and so only a small fraction of the voltage signal will reach there.

Biological neurons have a variety of intrinsic properties because of the large number of voltage dependent currents that control their activity. Neuromodulatory substances modify both the balance of conductances that determine intrinsic properties and the strength of synapses. These mechanisms alter circuit dynamics, and suggest that functional circuits exist only in the modulatory environment in which they operate. 1 INTRODUCTION Many studies of artificial neural networks employ model neurons and synapses that are considerably simpler than their biological counterparts.

Motivated by mathematical modeling, analog implementation and distributed simulation of neural networks, we present a definition of asynchronous dynamics of general CT dynamical systems defined by ordinary differential equations, based on notions of local times and communication times. We provide some preliminary results on globally asymptotical convergence of asynchronous dynamics for contractive and monotone CT dynamical systems. When applying the results to neural networks, we obtain some conditions that ensure additive-type neural networks to be asynchronizable.

It is well known that a given cortical neuron can respond with a different firing pattern for the same synaptic input, depending on its firing history and on the effects of modulator transmitters (see [Connors and Gutnick, 1990] for a review). The time span of different channel conductances is very broad, and the influence of some ionic currents varies with the history of the membrane potential [Lytton, 1991]. Motivated by the history-dependent nature of neuronal firing, we continue.our