We prove that the Canonical Distortion Measure (CDM) [2, 3] is the optimal distance measure to use for I nearest-neighbour (l-NN) classification, and show that it reduces to squared Euclidean distance in feature space for function classes that can be expressed as linear combinations of a fixed set of features. PAClike bounds are given on the samplecomplexity required to learn the CDM. An experiment is presented in which a neural network CDM was learnt for a Japanese OCR environment and then used to do INN classification.

Our model consists of a classical energy mechanism whose output is divided by nonclassical gain control and texture contrast mechanisms. We apply this model to review movies, a stimulus sequence that replicates the stimulation a cell receives during free viewing of natural images. Data were collected from three cells using five different review movies, and the model was fit separately to the data from each movie. For the energy mechanism alone we find modest but significant correlations (rE 0.41, 0.43, 0.59, 0.35) between model and data. These correlations are improved somewhat when we allow for suppressive surround effects (rE G 0.42, 0.56, 0.60, 0.37). In one case the inclusion of a delayed suppressive surround dramatically improves the fit to the data by modifying the time course of the model's response.

We have studied the application of an independent component analysis (ICA) approach to the identification and possible removal of artifacts from a magnetoencephalographic (MEG) recording.

We discuss a solution to the problem of separating waveforms produced by multiple cells in an extracellular neural recording. We take an explicitly probabilistic approach, using latent-variable models of varying sophistication to describe the distribution of waveforms produced by a single cell. The models range from a single Gaussian distribution of waveforms for each cell to a mixture of hidden Markov models. We stress the overall statistical structure of the approach, allowing the details of the generative model chosen to depend on the specific neural preparation.

In macaque inferotemporal cortex (IT), neurons have been found to respond selectively to complex shapes while showing broad tuning ("invariance") with respect to stimulus transformations such as translation and scale changes and a limited tuning to rotation in depth.

Further, the greater the similarity between objects, the stronger is the dependence on object appearance, and the more important twodimensional (2D) image information becomes. These findings, however, do not rule out the use of 3D structural information in recognition, and the degree to which 3D information is used in visual memory is an important issue. Liu, Knill, & Kersten (1995) showed that any model that is restricted to rotations in the image plane of independent 2D templates could not account for human performance in discriminating novel object views. We now present results from models of generalized radial basis functions (GRBF), 2D nearest neighbor matching that allows 2D affine transformations, and a Bayesian statistical estimator that integrates over all possible 2D affine transformations. The performance of the human observers relative to each of the models is better for the novel views than for the familiar template views, suggesting that humans generalize better to novel views from template views. The Bayesian estimator yields the optimal performance with 2D affine transformations and independent 2D templates. Therefore, models of 2D affine matching operations with independent 2D templates are unlikely to account for human recognition performance.

In most neural network models, synapses are treated as static weights that change only on the slow time scales of learning. In fact, however, synapses are highly dynamic, and show use-dependent plasticity over a wide range of time scales. Moreover, synaptic transmission is an inherently stochastic process: a spike arriving at a presynaptic terminal triggers release of a vesicle of neurotransmitter from a release site with a probability that can be much less than one. Changes in release probability represent one of the main mechanisms by which synaptic efficacy is modulated in neural circuits. We propose and investigate a simple model for dynamic stochastic synapses that can easily be integrated into common models for neural computation. We show through computer simulations and rigorous theoretical analysis that this model for a dynamic stochastic synapse increases computational power in a nontrivial way. Our results may have implications for the processing of time-varying signals by both biological and artificial neural networks. A synapse 8 carries out computations on spike trains, more precisely on trains of spikes from the presynaptic neuron. Each spike from the presynaptic neuron mayor may not trigger the release of a neurotransmitter-filled vesicle at the synapse.

In normal vision, the inputs from the two eyes are integrated into a single percept. When dissimilar images are presented to the two eyes, however, perceptual integration gives way to alternation between monocular inputs, a phenomenon called binocular rivalry. Although recent evidence indicates that binocular rivalry involves a modulation of neuronal responses in extrastriate cortex, the basic mechanisms responsible for differential processing of con:6.icting

We propose a model for early visual processing in primates. The model consists of a population of linear spatial filters which interact through nonlinear excitatory and inhibitory pooling. Statistical estimation theory is then used to derive human psychophysical thresholds from the responses of the entire population of units. The model is able to reproduce human thresholds for contrast and orientation discrimination tasks, and to predict contrast thresholds in the presence of masks of varying orientation and spatial frequency.

Most computational engineering based loosely on biology uses continuous variables to represent neural activity. Yet most neurons communicate with action potentials. The engineering view is equivalent to using a rate-code for representing information and for computing. An increasing number of examples are being discovered in which biology may not be using rate codes. Information can be represented using the timing of action potentials, and efficiently computed with in this representation. The "analog match" problem of odour identification is a simple problem which can be efficiently solved using action potential timing and an underlying rhythm.