The expensive fine-grained annotation and data scarcity have become the primary obstacles for the widespread adoption of deep learning-based Whole Slide Images (WSI) classification algorithms in clinical practice. Unlike few-shot learning methods in natural images that can leverage the labels of each image, existing few-shot WSI classification methods only utilize a small number of fine-grained labels or weakly supervised slide labels for training in order to avoid expensive fine-grained annotation. They lack sufficient mining of available WSIs, severely limiting WSI classification performance. To address the above issues, we propose a novel and efficient dual-tier few-shot learning paradigm for WSI classification, named FAST. FAST consists of a dual-level annotation strategy and a dual-branch classification framework.

Diffusion Purification, purifying noised images with diffusion models, has been widely used for enhancing certified robustness via randomized smoothing. However, existing frameworks often grapple with the balance between efficiency and effectiveness. While the Denoising Diffusion Probabilistic Model (DDPM) offers an efficient single-step purification, it falls short in ensuring purified images reside on the data manifold. Conversely, the Stochastic Diffusion Model effectively places purified images on the data manifold but demands solving cumbersome stochastic differential equations, while its derivative, the Probability Flow Ordinary Differential Equation (PF-ODE), though solving simpler ordinary differential equations, still requires multiple computational steps. In this work, we demonstrated that an ideal purification pipeline should generate the purified images on the data manifold that are as much semantically aligned to the original images for effectiveness in one step for efficiency. Therefore, we introduced Consistency Purification, an efficiency-effectiveness Pareto superior purifier compared to the previous work.

Machine unlearning is motivated by principles of data autonomy. The premise is that a person can request to have their data's influence removed from deployed models, and those models should be updated as if they were retrained without the person's data. We show that these updates expose individuals to high-accuracy reconstruction attacks which allow the attacker to recover their data in its entirety, even when the original models are so simple that privacy risk might not otherwise have been a concern. We show how to mount a near-perfect attack on the deleted data point from linear regression models. We then generalize our attack to other loss functions and architectures, and empirically demonstrate the effectiveness of our attacks across a wide range of datasets (capturing both tabular and image data). Our work highlights that privacy risk is significant even for extremely simple model classes when individuals can request deletion of their data from the model.

We consider the task of active geo-localization (AGL) in which an agent uses a sequence of visual cues observed during aerial navigation to find a target specified through multiple possible modalities. This could emulate a UAV involved in a search-and-rescue operation navigating through an area, observing a stream of aerial images as it goes. The AGL task is associated with two important challenges. Firstly, an agent must deal with a goal specification in one of multiple modalities (e.g., through a natural language description) while the search cues are provided in other modalities (aerial imagery). The second challenge is limited localization time (e.g., limited battery life, urgency) so that the goal must be localized as efficiently as possible, i.e. the agent must effectively leverage its sequentially observed aerial views when searching for the goal. To address these challenges, we propose GOMAA-Geo -- a goal modality agnostic active geo-localization agent -- for zero-shot generalization between different goal modalities. Our approach combines cross-modality contrastive learning to align representations across modalities with supervised foundation model pretraining and reinforcement learning to obtain highly effective navigation and localization policies. Through extensive evaluations, we show that GOMAA-Geo outperforms alternative learnable approaches and that it generalizes across datasets -- e.g., to disaster-hit areas without seeing a single disaster scenario during training -- and goal modalities -- e.g., to ground-level imagery or textual descriptions, despite only being trained with goals specified as aerial views. Our code is available at: https://github.com/mvrl/GOMAA-Geo.

Considering various data modalities, such as images, videos, and text, humans perform causal reasoning using high-level causal variables, as opposed to operating at the low, pixel level from which the data comes. In practice, most causal reasoning methods assume that the data is described as granular as the underlying causal generative factors, which is often violated in various AI tasks. This mismatch translates into a lack of guarantees in various tasks such as generative modeling, decision-making, fairness, and generalizability, to cite a few. In this paper, we acknowledge this issue and study the problem of causal disentangled representation learning from a combination of data gathered from various heterogeneous domains and assumptions in the form of a latent causal graph. To the best of our knowledge, the proposed work is the first to consider i) non-Markovian causal settings, where there may be unobserved confounding, ii) arbitrary distributions that arise from multiple domains, and iii) a relaxed version of disentanglement. Specifically, we introduce graphical criteria that allow for disentanglement under various conditions. Building on these results, we develop an algorithm that returns a causal disentanglement map, highlighting which latent variables can be disentangled given the combination of data and assumptions. The theory is corroborated by experiments.

The pre-trained point cloud model based on Masked Point Modeling (MPM) has exhibited substantial improvements across various tasks. However, these models heavily rely on the Transformer, leading to quadratic complexity and limited decoder, hindering their practice application. To address this limitation, we first conduct a comprehensive analysis of existing Transformer-based MPM, emphasizing the idea that redundancy reduction is crucial for point cloud analysis. To this end, we propose a Locally constrained Compact point cloud Model (LCM) consisting of a locally constrained compact encoder and a locally constrained Mamba-based decoder. Our encoder replaces self-attention with our local aggregation layers to achieve an elegant balance between performance and efficiency. Considering the varying information density between masked and unmasked patches in the decoder inputs of MPM, we introduce a locally constrained Mamba-based decoder. This decoder ensures linear complexity while maximizing the perception of point cloud geometry information from unmasked patches with higher information density. Extensive experimental results show that our compact model significantly surpasses existing Transformer-based models in both performance and efficiency, especially our LCM-based Point-MAE model, compared to the Transformer-based model, achieved an improvement of 1.84%, 0.67%, and 0.60% in performance on the three variants of ScanObjectNN while reducing parameters by 88% and computation by 73%.

In this paper we present a novel method for efficient and effective 3D surface reconstruction in open scenes. Existing Neural Radiance Fields (NeRF) based works typically require extensive training and rendering time due to the adopted implicit representations. In contrast, 3D Gaussian splatting (3DGS) uses an explicit and discrete representation, hence the reconstructed surface is built by the huge number of Gaussian primitives, which leads to excessive memory consumption and rough surface details in sparse Gaussian areas.To address these issues, we propose Gaussian Voxel Kernel Functions (GVKF), which establish a continuous scene representation based on discrete 3DGS through kernel regression.

Tandem mass spectrometry has played a pivotal role in advancing proteomics, enabling the analysis of protein composition in biological tissues. Many deep learning methods have been developed for \emph{de novo} peptide sequencing task, i.e., predicting the peptide sequence for the observed mass spectrum. However, two key challenges seriously hinder the further research of this important task. Firstly, since there is no consensus for the evaluation datasets, the empirical results in different research papers are often not comparable, leading to unfair comparison. Secondly, the current methods are usually limited to amino acid-level or peptide-level precision and recall metrics.

A challenging problem in many modern machine learning tasks is to process weight-space features, i.e., to transform or extract information from the weights and gradients of a neural network. Recent works have developed promising weight-space models that are equivariant to the permutation symmetries of simple feedforward networks. However, they are not applicable to general architectures, since the permutation symmetries of a weight space can be complicated by recurrence or residual connections. This work proposes an algorithm that automatically constructs permutation equivariant models, which we refer to as universal neural functionals (UNFs), for any weight space. Among other applications, we demonstrate how UNFs can be substituted into existing learned optimizer designs, and find promising improvements over prior methods when optimizing small image classifiers and language models. Our results suggest that learned optimizers can benefit from considering the (symmetry) structure of the weight space they optimize.

Monocular depth estimation (MDE) is fundamental for deriving 3D scene structures from 2D images. While state-of-the-art monocular relative depth estimation (MRDE) excels in estimating relative depths for in-the-wild images, current monocular metric depth estimation (MMDE) approaches still face challenges in handling unseen scenes. Since MMDE can be viewed as the composition of MRDE and metric scale recovery, we attribute this difficulty to scene dependency, where MMDE models rely on scenes observed during supervised training for predicting scene scales during inference. To address this issue, we propose to use humans as landmarks for distilling scene-independent metric scale priors from generative painting models.