When training neural networks by the classical backpropagation algorithm thewhole problem to learn must be expressed by a set of inputs and desired outputs. However, we often have high-level knowledge about the learning problem. In optical character recognition (OCR), for instance, weknow that the classification should be invariant under a set of transformations like rotation or translation. We propose a new modular classification system based on several autoassociative multilayer perceptrons whichallows the efficient incorporation of such knowledge. Results are reported on the NIST database of upper case handwritten letters and compared to other approaches to the invariance problem. 1 INCORPORATION OF EXPLICIT KNOWLEDGE The aim of supervised learning is to learn a mapping between the input and the output space from a set of example pairs (input, desired output). The classical implementation in the domain of neural networks is the backpropagation algorithm. If this learning set is sufficiently representative of the underlying data distributions, one hopes that after learning, the system is able to generalize correctly to other inputs of the same distribution.

The most commonly used neural network models are not well suited to direct digital implementations because each node needs to perform a large number of operations between floating point values. Fortunately, the ability to learn from examples and to generalize is not restricted to networks ofthis type. Indeed, networks where each node implements a simple Boolean function (Boolean networks) can be designed in such a way as to exhibit similar properties. Two algorithms that generate Boolean networks from examples are presented. The results show that these algorithms generalize very well in a class of problems that accept compact Boolean network descriptions. The techniques described are general and can be applied to tasks that are not known to have that characteristic. Two examples of applications are presented: image reconstruction and handwritten character recognition.

We propose a trajectory planning and control theory for continuous movements such as connected cursive handwriting and continuous natural speech. Its hardware is based on our previously proposed forward-inverse-relaxation neural network (Wada & Kawato, 1993). Computationally, its optimization principle is the minimum torquechange criterion. Regarding the representation level, hard constraints satisfied by a trajectory are represented as a set of via-points extracted from a handwritten character. Accordingly, we propose a via-point estimation algorithm that estimates via-points by repeating the trajectory formation of a character and the via-point extraction from the character. In experiments, good quantitative agreement is found between human handwriting data and the trajectories generated by the theory. Finally, we propose a recognition schema based on the movement generation. We show a result in which the recognition schema is applied to the handwritten character recognition and can be extended to the phoneme timing estimation of natural speech. 1 INTRODUCTION In reaching movements, trajectory formation is an ill-posed problem because the hand can move along an infinite number of possible trajectories from the starting to the target point.

The task of drug activity prediction is to predict the activity of proposed drug compounds by learning from the observed activity of previously-synthesized drug compounds. Accurate drug activity prediction can save substantial time and money by focusing the efforts of chemists and biologists on the synthesis and testing of compounds whose predicted activity is high. If the requirements for highly active binding can be displayed in three dimensions, chemists can work from such displays to design new compounds having high predicted activity. Drug molecules usually act by binding to localized sites on large receptor molecules or large enyzme molecules. One reasonable way to represent drug molecules is to capture the location of their surface in the (fixed) frame of reference of the (hypothesized) binding site.

The most commonly used neural network models are not well suited to direct digital implementations because each node needs to perform a large number of operations between floating point values. Fortunately, the ability to learn from examples and to generalize is not restricted to networks ofthis type. Indeed, networks where each node implements a simple Boolean function (Boolean networks) can be designed in such a way as to exhibit similar properties. Two algorithms that generate Boolean networks from examples are presented. The results show that these algorithms generalize very well in a class of problems that accept compact Boolean network descriptions. The techniques described are general and can be applied to tasks that are not known to have that characteristic. Two examples of applications are presented: image reconstruction and handwritten character recognition.

We propose a trajectory planning and control theory for continuous movements such as connected cursive handwriting and continuous natural speech. Its hardware is based on our previously proposed forward-inverse-relaxation neural network (Wada & Kawato, 1993). Computationally, its optimization principle is the minimum torquechange criterion. Regarding the representation level, hard constraints satisfied by a trajectory are represented as a set of via-points extracted from a handwritten character. Accordingly, we propose a via-point estimation algorithm that estimates via-points by repeating the trajectory formation of a character and the via-point extraction from the character. In experiments, good quantitative agreement is found between human handwriting data and the trajectories generated by the theory. Finally, we propose a recognition schema based on the movement generation. We show a result in which the recognition schema is applied to the handwritten character recognition and can be extended to the phoneme timing estimation of natural speech. 1 INTRODUCTION In reaching movements, trajectory formation is an ill-posed problem because the hand can move along an infinite number of possible trajectories from the starting to the target point.

The task of drug activity prediction is to predict the activity of proposed drug compounds by learning from the observed activity of previously-synthesized drug compounds. Accurate drug activity prediction can save substantial time and money by focusing the efforts of chemists and biologists on the synthesis and testing of compounds whose predicted activity is high. If the requirements for highly active binding can be displayed in three dimensions, chemists can work from such displays to design new compounds having high predicted activity. Drug molecules usually act by binding to localized sites on large receptor molecules or large enyzme molecules. One reasonable way to represent drug molecules is to capture the location of their surface in the (fixed) frame of reference of the (hypothesized) binding site.

We propose a trajectory planning and control theory for continuous movements such as connected cursive handwriting and continuous natural speech. Its hardware is based on our previously proposed forward-inverse-relaxation neural network (Wada & Kawato, 1993). Computationally, its optimization principle is the minimum torquechange criterion.Regarding the representation level, hard constraints satisfied by a trajectory are represented as a set of via-points extracted from a handwritten character. Accordingly, we propose a via-point estimation algorithm that estimates via-points by repeating the trajectory formation of a character and the via-point extraction from the character. In experiments, good quantitative agreement is found between human handwriting data and the trajectories generated by the theory. Finally, we propose a recognition schema based on the movement generation. We show a result in which the recognition schema is applied to the handwritten character recognition and can be extended to the phoneme timing estimation of natural speech. 1 INTRODUCTION In reaching movements, trajectory formation is an ill-posed problem because the hand can move along an infinite number of possible trajectories from the starting to the target point.

Thomas G. Dietterich Arris Pharmaceutical Corporation and Oregon State University Corvallis, OR 97331-3202 Ajay N. Jain Arris Pharmaceutical Corporation 385 Oyster Point Blvd., Suite 3 South San Francisco, CA 94080 Richard H. Lathrop and Tomas Lozano-Perez Arris Pharmaceutical Corporation and MIT Artificial Intelligence Laboratory 545 Technology Square Cambridge, MA 02139 Abstract In drug activity prediction (as in handwritten character recognition), thefeatures extracted to describe a training example depend on the pose (location, orientation, etc.) of the example. In handwritten characterrecognition, one of the best techniques for addressing thisproblem is the tangent distance method of Simard, LeCun and Denker (1993). Jain, et al. (1993a; 1993b) introduce a new technique-dynamic reposing-that also addresses this problem. Dynamicreposing iteratively learns a neural network and then reposes the examples in an effort to maximize the predicted output values.New models are trained and new poses computed until models and poses converge. This paper compares dynamic reposing to the tangent distance method on the task of predicting the biological activityof musk compounds.

We propose in this paper a statistical model (planar hidden Markov model - PHMM) describing statistical properties of images. The model generalizes the single-dimensional HMM, used for speech processing, to the planar case. For this model to be useful an efficient segmentation algorithm, similar to the Viterbi algorithm for HMM, must exist We present conditions in terms of the PHMM parameters that are sufficient to guarantee that the planar segmentation problem can be solved in polynomial time, and describe an algorithm for that. This algorithm aligns optimally the image with the model, and therefore is insensitive to elastic distortions of images. Using this algorithm a joint optima1 segmentation and recognition of the image can be performed, thus overcoming the weakness of traditional OCR systems where segmentation is performed independently before the recognition leading to unrecoverable recognition errors. Tbe PHMM approach was evaluated using a set of isolated band-written digits. An overall digit recognition accuracy of 95% was acbieved. An analysis of the results showed that even in the simple case of recognition of isolated characters, the elimination of elastic distortions enhances the performance Significantly. We expect that the advantage of this approach will be even more significant for tasks such as connected writing recognition/spotting, for whicb there is no known high accuracy method of recognition.