In recent biomedical scientific problems, it is a fundamental issue to integratively cluster a set of objects from multiple sources of datasets. Such problems are mostly encountered in genomics, where data is collected from various sources, and typically represent distinct yet complementary information. Integrating these data sources for multi-source clustering is challenging due to their complex dependence structure including directional dependency. Particularly in genomics studies, it is known that there is certain directional dependence between DNA expression, DNA methylation, and RNA expression, widely called The Central Dogma. Most of the existing multi-view clustering methods either assume an independent structure or pair-wise (non-directional) dependency, thereby ignoring the directional relationship. Motivated by this, we propose a copula-based multi-view clustering model where a copula enables the model to accommodate the directional dependence existing in the datasets. We conduct a simulation experiment where the simulated datasets exhibiting inherent directional dependence: it turns out that ignoring the directional dependence negatively affects the clustering performance. As a real application, we applied our model to the breast cancer tumor samples collected from The Cancer Genome Altas (TCGA).

Reproducing kernel Hilbert spaces (RKHSs) play an important role in many statistics and machine learning applications ranging from support vector machines to Gaussian processes and kernel embeddings of distributions. Operators acting on such spaces are, for instance, required to embed conditional probability distributions in order to implement the kernel Bayes rule and build sequential data models. It was recently shown that transfer operators such as the Perron-Frobenius or Koopman operator can also be approximated in a similar fashion using covariance and cross-covariance operators and that eigenfunctions of these operators can be obtained by solving associated matrix eigenvalue problems. The goal of this paper is to provide a solid functional analytic foundation for the eigenvalue decomposition of RKHS operators and to extend the approach to the singular value decomposition. The results are illustrated with simple guiding examples.

Bayesian statistical inference loses predictive optimality when generative models are misspecified. Working within an existing coherent loss-based generalisation of Bayesian inference, we show existing Modular/Cut-model inference is coherent, and write down a new family of Semi-Modular Inference (SMI) schemes, indexed by an influence parameter, with Bayesian inference and Cut-models as special cases. We give a meta-learning criterion and estimation procedure to choose the inference scheme. This returns Bayesian inference when there is no misspecification. The framework applies naturally to Multi-modular models. Cut-model inference allows directed information flow from well-specified modules to misspecified modules, but not vice versa. An existing alternative power posterior method gives tunable but undirected control of information flow, improving prediction in some settings. In contrast, SMI allows tunable and directed information flow between modules. We illustrate our methods on two standard test cases from the literature and a motivating archaeological data set.

Modelling uncertainty arising from input-dependent label noise is an increasingly important problem. A state-of-the-art approach for classification [Kendall and Gal, 2017] places a normal distribution over the softmax logits, where the mean and variance of this distribution are learned functions of the inputs. This approach achieves impressive empirical performance but lacks theoretical justification. We show that this model is a special case of a well known and theoretically understood model studied in econometrics. Under this view the softmax over the logit distribution is a smooth approximation to an argmax, where the approximation is exact in the zero temperature limit. We further illustrate that the softmax temperature controls a bias-variance trade-off and the optimal point on this trade-off is not always found at 1.0. By tuning the softmax temperature, we achieve improved performance on well known image classification benchmarks with controlled label noise. For image segmentation, where input-dependent label noise naturally arises, we show that tuning the temperature increases the mean IoU on the PASCAL VOC and Cityscapes datasets by more than 1% over the state-of-the-art model and a strong baseline that does not model this noise source.

Bayes' theorem (alternatively Bayes' law or Bayes' rule) has been called the most powerful rule of probability and statistics. It describes the probability of an event, based on prior knowledge of conditions that might be related to the event. For example, if a disease is related to age, then, using Bayes' theorem, a person's age can be used to more accurately assess the probability that they have the disease, compared to the assessment of the probability of disease made without knowledge of the person's age. It is a powerful law of probability that brings in the concept of'subjectivity' or'the degree of belief' into the cold, hard statistical modeling. Bayes' rule is the only mechanism that can be used to gradually update the probability of an event as the evidence or data is gathered sequentially.

Change point detection is an important part of time series analysis, as the presence of a change point indicates an abrupt and significant change in the data generating process. While many algorithms for change point detection exist, little attention has been paid to evaluating their performance on real-world time series. Algorithms are typically evaluated on simulated data and a small number of commonly-used series with unreliable ground truth. Clearly this does not provide sufficient insight into the comparative performance of these algorithms. Therefore, instead of developing yet another change point detection method, we consider it vastly more important to properly evaluate existing algorithms on real-world data. To achieve this, we present the first data set specifically designed for the evaluation of change point detection algorithms, consisting of 37 time series from various domains. Each time series was annotated by five expert human annotators to provide ground truth on the presence and location of change points. We analyze the consistency of the human annotators, and describe evaluation metrics that can be used to measure algorithm performance in the presence of multiple ground truth annotations. Subsequently, we present a benchmark study where 13 existing algorithms are evaluated on each of the time series in the data set. This study shows that binary segmentation (Scott and Knott, 1974) and Bayesian online change point detection (Adams and MacKay, 2007) are among the best performing methods. Our aim is that this data set will serve as a proving ground in the development of novel change point detection algorithms.

Training generative models that can generate high-quality text with sufficient diversity is an important open problem for Natural Language Generation (NLG) community. Recently, generative adversarial models have been applied extensively on text generation tasks, where the adversarially trained generators alleviate the exposure bias experienced by conventional maximum likelihood approaches and result in promising generation quality. However, due to the notorious defect of mode collapse for adversarial training, the adversarially trained generators face a quality-diversity trade-off, i.e., the generator models tend to sacrifice generation diversity severely for increasing generation quality. In this paper, we propose a novel approach which aims to improve the performance of adversarial text generation via efficiently decelerating mode collapse of the adversarial training. To this end, we introduce a cooperative training paradigm, where a language model is cooperatively trained with the generator and we utilize the language model to efficiently shape the data distribution of the generator against mode collapse. Moreover, instead of engaging the cooperative update for the generator in a principled way, we formulate a meta learning mechanism, where the cooperative update to the generator serves as a high level meta task, with an intuition of ensuring the parameters of the generator after the adversarial update would stay resistant against mode collapse. In the experiment, we demonstrate our proposed approach can efficiently slow down the pace of mode collapse for the adversarial text generators. Overall, our proposed method is able to outperform the baseline approaches with significant margins in terms of both generation quality and diversity in the testified domains.

Spatial prediction is commonly achieved under the assumption of a Gaussian random field (GRF) by obtaining maximum likelihood estimates of parameters, and then using the kriging equations to arrive at predicted values. For massive datasets, fixed rank kriging using the Expectation-Maximization (EM) algorithm for estimation has been proposed as an alternative to the usual but computationally prohibitive kriging method. The method reduces computation cost of estimation by redefining the spatial process as a linear combination of basis functions and spatial random effects. A disadvantage of this method is that it imposes constraints on the relationship between the observed locations and the knots. We develop an alternative method that utilizes the Spatial Mixed Effects (SME) model, but allows for additional flexibility by estimating the range of the spatial dependence between the observations and the knots via an Alternating Expectation Conditional Maximization (AECM) algorithm. Experiments show that our methodology improves estimation without sacrificing prediction accuracy while also minimizing the additional computational burden of extra parameter estimation. The methodology is applied to a temperature data set archived by the United States National Climate Data Center, with improved results over previous methodology.

Despite the massive popularity of the Asian Handicap (AH) football betting market, it has not been adequately studied by the relevant literature. This paper combines rating systems with hybrid Bayesian networks and presents the first published model specifically developed for prediction and assessment of the AH betting market. The results are based on 13 English Premier League seasons and are compared to the traditional 1X2 market. Different betting situations have been examined including a) both average and maximum (best available) market odds, b) all possible betting decision thresholds between predicted and published odds, c) optimisations for both return-on-investment and profit, and d) simple stake adjustments to investigate how the variance of returns changes when targeting equivalent profit in both 1X2 and AH markets. While the AH market is found to share the inefficiencies of the traditional 1X2 market, the findings reveal both interesting differences as well as similarities between the two.

Reinforcement learning (RL) is a popular paradigm for addressing sequential decision tasks in which the agent has only limited environmental feedback. Despite many advances over the past three decades, learning in many domains still requires a large amount of interaction with the environment, which can be prohibitively expensive in realistic scenarios. To address this problem, transfer learning has been applied to reinforcement learning such that experience gained in one task can be leveraged when starting to learn the next, harder task. More recently, several lines of research have explored how tasks, or data samples themselves, can be sequenced into a curriculum for the purpose of learning a problem that may otherwise be too difficult to learn from scratch. In this article, we present a framework for curriculum learning (CL) in reinforcement learning, and use it to survey and classify existing CL methods in terms of their assumptions, capabilities, and goals. Finally, we use our framework to find open problems and suggest directions for future RL curriculum learning research.