Diagnosis of human disease or machine fault is a missing data problem since many variables are initially unknown. Additional information needs to be obtained. The j oint probability distribution of the data can be used to solve this problem. We model this with mixture models whose parameters are estimated by the EM algorithm. This gives the benefit that missing data in the database itself can also be handled correctly. The request for new information to refine the diagnosis is performed using the maximum utility principle. Since the system is based on learning it is domain independent and less labor intensive than expert systems or probabilistic networks. An example using a heart disease database is presented.

In practical situations, experts may visually examine the images and provide a subjective noisy estimate of the truth. Calibrating the reliability and bias of expert labellers is a nontrivial problem. In this paper we discuss some of our recent work on this topic in the context of detecting small volcanoes in Magellan SAR images of Venus. Empirical results (using the Expectation-Maximization procedure) suggest that accounting for subjective noise can be quite significant interms of quantifying both human and algorithm detection performance.

If data collection is costly, there is much to be gained by actively selecting particularlyinformative data points in a sequential way. In a Bayesian decision-theoretic framework we develop a query selection criterionwhich explicitly takes into account the intended use of the model predictions. By Markov Chain Monte Carlo methods the necessary quantities can be approximated to a desired precision. Asthe number of data points grows, the model complexity is modified by a Bayesian model selection strategy. The properties oftwo versions of the criterion ate demonstrated in numerical experiments.

We present a deterministic annealing variant of the EM algorithm maximum likelihood parameter estimation problems. In ourfor approach, the EM process is reformulated as the problem of minimizing the thermodynamic free energy by using the principle of maximum entropy and statistical mechanics analogy. Unlike simulated deterministicallyannealing approaches, this minimization is performed. Moreover, the derived algorithm, unlike the conventional better estimates free of the initialEM algorithm, can obtain parameter values.

Signal processing and classification algorithms often have limited applicability resulting from an inaccurate model of the signal's underlying structure. We present here an efficient, Bayesian algorithm for modeling a signal composed of the superposition of brief, Poisson-distributed functions. This methodology is applied to the specific problem of modeling and classifying extracellular neural waveforms which are composed of a superposition of an unknown number of action potentials CAPs). Previous approaches have had limited success due largely to the problems of determining the spike shapes, deciding how many are shapes distinct, and decomposing overlapping APs. A Bayesian solution to each of these problems is obtained by inferring a probabilistic model of the waveform. This approach quantifies the uncertainty of the form and number of the inferred AP shapes and is used to obtain an efficient method for decomposing complex overlaps. This algorithm can extract many times more information than previous methods and facilitates the extracellular investigation of neuronal classes and of interactions within neuronal circuits.

MacKay's Bayesian framework for backpropagation is conceptually appealing as well as practical. It automatically adjusts the weight decay parameters during training, and computes the evidence for each trained network. The evidence is proportional to our belief in the model. In this paper, the framework is extended to pruned nets, leading to an Ockham Factor for "tuning the architecture to the data". A committee of networks, selected by their high evidence, is a natural Bayesian construction.

The past several years have seen a tremendous growth in the complexity of the recognition, estimation and control tasks expected of neural networks. In solving these tasks, one is faced with a large variety of learning algorithms and a vast selection of possible network architectures. After all the training, how does one know which is the best network? This decision is further complicated by the fact that standard techniques can be severely limited by problems such as over-fitting, data sparsity and local optima. The usual solution to these problems is a winner-take-all cross-validatory model selection.

Recent work by Becker and Hinton (Becker and Hinton, 1992) shows a promising mechanism, based on maximizing mutual information assuming spatial coherence, by which a system can selforganize itself to learn visual abilities such as binocular stereo. We introduce a more general criterion, based on Bayesian probability theory, and thereby demonstrate a connection to Bayesian theories of visual perception and to other organization principles for early vision (Atick and Redlich, 1990). Methods for implementation using variants of stochastic learning are described and, for the special case of linear filtering, we derive an analytic expression for the output. 1 Introduction The input intensity patterns received by the human visual system are typically complicated functions of the object surfaces and light sources in the world. It *Lei Xu was a research scholar in the Division of Applied Sciences at Harvard University while this work was performed. Thus the visual system must be able to extract information from the input intensities that is relatively independent of the actual intensity values.

Model-based object recognition solves the problem of invariant recognition by relying on stored prototypes at unit scale positioned at the origin of an object-centered coordinate system. Elastic matching techniques are used to find a correspondence between features of the stored model and the data and can also compute the parameters of the transformation the observed instance has undergone relative to the stored model.

The conventional Bayesian justification of backprop is that it finds the MAP weight vector. As this paper shows, to find the MAP io function instead one must add a correction tenn to backprop. That tenn biases one towards io functions with small description lengths, and in particular favors (some kinds of) feature-selection, pruning, and weight-sharing.