Visual-spatial understanding, the ability to infer object relationships and layouts from visual input, is fundamental to downstream tasks such as robotic navigation and embodied interaction. However, existing methods face spatial uncertainty and data scarcity, limiting the 3D spatial reasoning capability of pre-trained vision-language models (VLMs). To address these challenges, we present a unified framework for enhancing 3D spatial reasoning in pre-trained VLMs without modifying their architecture. This framework combines SpatialMind, a structured prompting strategy that decomposes complex scenes and questions into interpretable reasoning steps, with ScanForgeQA, a scalable question-answering dataset built from diverse 3D simulation scenes through an automated construction process designed for fine-tuning. Extensive experiments across multiple benchmarks demonstrate the individual and combined effectiveness of our prompting and fine-tuning strategies, and yield insights that may inspire future research on visual-spatial understanding.

Reasoning is central to purposeful action, yet most robotic foundation models map perception and instructions directly to control, which limits adaptability, generalization, and semantic grounding. We introduce Action Reasoning Models (ARMs), a class of robotic foundation models that integrate perception, planning, and control through a structured three-stage pipeline. Our model, MolmoAct, encodes observations and instructions into depth-aware perception tokens, generates mid-level spatial plans as editable trajectory traces, and predicts precise low-level actions, enabling explainable and steerable behavior. MolmoAct-7B-D achieves strong performance across simulation and real-world settings: 70.5% zero-shot accuracy on SimplerEnv Visual Matching tasks, surpassing closed-source Pi-0 and GR00T N1.5; 86.6% average success on LIBERO, including an additional 6.3% gain over ThinkAct on long-horizon tasks; and in real-world fine-tuning, an additional 10% (single-arm) and an additional 22.7% (bimanual) task progression over Pi-0-FAST. It also outperforms baselines by an additional 23.3% on out-of-distribution generalization and achieves top human-preference scores for open-ended instruction following and trajectory steering. Furthermore, we release, for the first time, the MolmoAct Dataset -- a mid-training robot dataset comprising over 10,000 high quality robot trajectories across diverse scenarios and tasks. Training with this dataset yields an average 5.5% improvement in general performance over the base model. We release all model weights, training code, our collected dataset, and our action reasoning dataset, establishing MolmoAct as both a state-of-the-art robotics foundation model and an open blueprint for building ARMs that transform perception into purposeful action through structured reasoning. Blogpost: https://allenai.org/blog/molmoact

Recent advances in spatial omics technologies have revolutionized our ability to study biological systems with unprecedented resolution. By preserving the spatial context of molecular measurements, these methods enable comprehensive mapping of cellular het erogeneity, tissue architecture, and dynamic biological processes in developmental biology, neuroscience, oncology, and evolutionary studies . This review highlights a systematic overview of the continuous advancements in both technology and computational a lgorithms that are paving the way for a deeper, more systematic comprehension of the structure and mechanisms of mammalian tissues and organs by using spatial multi - omics . Our viewpoint demonstrates how advanced machine learning algorithms and multi - omics integrative modeling can decode complex biological processes, including the spatial organization and topological relationships of cells during organ development, as well as key molecular signatures and regulatory networks underlying tumorigenesis and metas tasis . Finally, we outline future directions for technological innovation and modeling insights of spatial omics in precision medicine.

Autonomous driving in dense, dynamic environments requires decision-making systems that can exploit both spatial structure and long-horizon temporal dependencies while remaining robust to uncertainty. This work presents a novel framework that integrates multi-channel bird's-eye-view occupancy grids with transformer-based sequence modeling for tactical driving in complex roundabout scenarios. To address the imbalance between frequent low-risk states and rare safety-critical decisions, we propose the Uncertainty-Weighted Decision Transformer (UWDT). UWDT employs a frozen teacher transformer to estimate per-token predictive entropy, which is then used as a weight in the student model's loss function. This mechanism amplifies learning from uncertain, high-impact states while maintaining stability across common low-risk transitions. Experiments in a roundabout simulator, across varying traffic densities, show that UWDT consistently outperforms other baselines in terms of reward, collision rate, and behavioral stability. The results demonstrate that uncertainty-aware, spatial-temporal transformers can deliver safer and more efficient decision-making for autonomous driving in complex traffic environments.

We present a new method to visualize data ensembles by constructing structured probabilistic representations in latent spaces, i.e., lower-dimensional representations of spatial data features. Our approach transforms the spatial features of an ensemble into a latent space through feature space conversion and unsupervised learning using a variational autoencoder (VAE). The resulting latent spaces follow multivariate standard Gaussian distributions, enabling analytical computation of confidence intervals and density estimation of the probabilistic distribution that generates the data ensemble. Preliminary results on a weather forecasting ensemble demonstrate the effectiveness and versatility of our method.

Visual-inertial fusion is crucial for a large amount of intelligent and autonomous applications, such as robot navigation and augmented reality. To bootstrap and achieve optimal state estimation, the spatial-temporal displacements between IMU and cameras must be calibrated in advance. Most existing calibration methods adopt continuous-time state representation, more specifically the B-spline. Despite these methods achieve precise spatial-temporal calibration, they suffer from high computational cost caused by continuous-time state representation. To this end, we propose a novel and extremely efficient calibration method that unleashes the power of discrete-time state representation. Moreover, the weakness of discrete-time state representation in temporal calibration is tackled in this paper. With the increasing production of drones, cellphones and other visual-inertial platforms, if one million devices need calibration around the world, saving one minute for the calibration of each device means saving 2083 work days in total. To benefit both the research and industry communities, our code will be open-source.

Contrast-enhanced computed tomography (CECT) is the primary imaging technique that provides valuable spatial-temporal information about lesions, enabling the accurate diagnosis and subclassification of pancreatic tumors. However, the high heterogeneity and variability of pancreatic tumors still pose substantial challenges for precise subtyping diagnosis. Previous methods fail to effectively explore the contextual information across multiple CECT phases commonly used in radiologists' diagnostic workflows, thereby limiting their performance. In this paper, we introduce, for the first time, an automatic way to combine the multi-phase CECT data to discriminate between pancreatic tumor subtypes, among which the key is using Mamba with promising learnability and simplicity to encourage both temporal and spatial modeling from multi-phase CECT. Specifically, we propose a dual hierarchical contrast-enhanced-aware Mamba module incorporating two novel spatial and temporal sampling sequences to explore intra and inter-phase contrast variations of lesions. A similarity-guided refinement module is also imposed into the temporal scanning modeling to emphasize the learning on local tumor regions with more obvious temporal variations. Moreover, we design the space complementary integrator and multi-granularity fusion module to encode and aggregate the semantics across different scales, achieving more efficient learning for subtyping pancreatic tumors. The experimental results on an in-house dataset of 270 clinical cases achieve an accuracy of 97.4% and an AUC of 98.6% in distinguishing between pancreatic ductal adenocarcinoma (PDAC) and pancreatic neuroendocrine tumors (PNETs), demonstrating its potential as a more accurate and efficient tool.

In this paper we present the first population-level, city-scale analysis of application usage on smartphones. Using deep packet inspection at the network operator level, we obtained a geo-tagged dataset with more than 6 million unique devices that launched more than 10,000 unique applications across the city of Shanghai over one week. We develop a technique that leverages transfer learning to predict which applications are most popular and estimate the whole usage distribution based on the Point of Interest (POI) information of that particular location. We demonstrate that our technique has an 83.0% hitrate in successfully identifying the top five popular applications, and a 0.15 RMSE when estimating usage with just 10% sampled sparse data. It outperforms by about 25.7% over the existing state-of-the-art approaches. Our findings pave the way for predicting which apps are relevant to a user given their current location, and which applications are popular where. The implications of our findings are broad: it enables a range of systems to benefit from such timely predictions, including operating systems, network operators, appstores, advertisers, and service providers.

Clustering high-dimensional multivariate spatiotemporal climate data is challenging due to complex temporal dependencies, evolving spatial interactions, and non-stationary dynamics. Conventional clustering methods, including recurrent and convolutional models, often struggle to capture both local and global temporal relationships while preserving spatial context. We present a time-distributed hybrid U-Net autoencoder that integrates a Bi-directional Temporal Graph Attention Transformer (B-TGAT) to guide efficient temporal clustering of multidimensional spatiotemporal climate datasets. The encoder and decoder are equipped with ConvLSTM2D modules that extract joint spatial--temporal features by modeling localized dynamics and spatial correlations over time, and skip connections that preserve multiscale spatial details during feature compression and reconstruction. At the bottleneck, B-TGAT integrates graph-based spatial modeling with attention-driven temporal encoding, enabling adaptive weighting of temporal neighbors and capturing both short and long-range dependencies across regions. This architecture produces discriminative latent embeddings optimized for clustering. Experiments on three distinct spatiotemporal climate datasets demonstrate superior cluster separability, temporal stability, and alignment with known climate transitions compared to state-of-the-art baselines. The integration of ConvLSTM2D, U-Net skip connections, and B-TGAT enhances temporal clustering performance while providing interpretable insights into complex spatiotemporal variability, advancing both methodological development and climate science applications.

Trajectory data has become a key resource for automated map in-ference due to its low cost, broad coverage, and continuous availability. However, uneven trajectory density often leads to frag-mented roads in sparse areas and redundant segments in dense regions, posing significant challenges for existing methods. To address these issues, we propose DGMap, a dual-decoding framework with global context awareness, featuring Multi-scale Grid Encoding, Mask-enhanced Keypoint Extraction, and Global Context-aware Relation Prediction. By integrating global semantic context with local geometric features, DGMap improves keypoint detection accuracy to reduce road fragmentation in sparse-trajectory areas. Additionally, the Global Context-aware Relation Prediction module suppresses false connections in dense-trajectory regions by modeling long-range trajectory patterns. Experimental results on three real-world datasets show that DGMap outperforms state-of-the-art methods by 5% in APLS, with notable performance gains on trajectory data from the Didi Chuxing platform