Today in Entertainment: Seth Meyers finds a new law of Trump physics; Jonathan Demme brought out performers' best DMX cancels L.A. performance due to'medical emergency' DMX cancels L.A. performance due to'medical emergency' The science on the Trump administration is a little closer to settled. "Late Night with Seth Meyers" offered a deep dive Wednesday night into the administration's apparent fondness for executive orders -- the president has signed 30 so far -- and highlighted how Trump the candidate was less enamored of the practice than Trump the president appears to be. "It is at this point like a law of physics," Meyers said at the beginning of one of his "A Closer Look" segments. "For every Trump action, there's an equal and opposite Trump clip." Meyers amusingly applied the same science to New Jersey Gov. Chris Christie's stance on executive orders as well.

Science is in the midst of a data crisis. Last year, there were more than 1.2 million new papers published in the biomedical sciences alone, bringing the total number of peer-reviewed biomedical papers to over 26 million. However, the average scientist reads only about 250 papers a year. Meanwhile, the quality of the scientific literature has been in decline. Some recent studies found that the majority of biomedical papers were irreproducible.

Current statistical inference problems in areas like astronomy, genomics, and marketing routinely involve the simultaneous testing of thousands -- even millions -- of null hypotheses. For high-dimensional multivariate distributions, these hypotheses may concern a wide range of parameters, with complex and unknown dependence structures among variables. In analyzing such hypothesis testing procedures, gains in efficiency and power can be achieved by performing variable reduction on the set of hypotheses prior to testing. We present in this paper an approach using data-adaptive multiple testing that serves exactly this purpose. This approach applies data mining techniques to screen the full set of covariates on equally sized partitions of the whole sample via cross-validation. This generalized screening procedure is used to create average ranks for covariates, which are then used to generate a reduced (sub)set of hypotheses, from which we compute test statistics that are subsequently subjected to standard multiple testing corrections. The principal advantage of this methodology lies in its providing valid statistical inference without the \textit{a priori} specifying which hypotheses will be tested. Here, we present the theoretical details of this approach, confirm its validity via a simulation study, and exemplify its use by applying it to the analysis of data on microRNA differential expression.

Essentially good hypotheses lead decision-makers like you to new and better ways to achieve your business goals. When you need to make decisions such as how much you should spend on advertising or what effect a price increase will have your customer base, it's easy to make wild assumptions or get lost in analysis paralysis. A business hypothesis solves this problem, because, at the start, it's based on some foundational information. In all of science, hypotheses are grounded in theory. Theory tells you what you can generally expect from a certain line of inquiry.

Chatbots offer the promise of frictionless access to goods, services and information, but creating effective bots can be deceptively tricky. The flip side of the opportunity to interact with users in a seamless, natural way is that user expectations can be prohibitively high. Bots need to be smart and provide greater convenience than apps -- a very effective UI paradigm tailored for today's mobile devices that has been carefully refined for more than a decade. The good news is that the belief that bots must master human language or replace apps to succeed is false. Bots will engage with consumers in new ways that combine the strengths of humans and machines to allow both structured and unstructured information to be exchanged naturally and efficiently.

Visual Analytics and Data Discovery allow analysis of big data sets to find insights and valuable information. This is much more than just classical Business Intelligence (BI). See this article for more details and motivation: "Using Visual Analytics to Make Better Decisions: the Death Pill Exa...". Let's take a look at important characteristics to choose the right tool for your use cases. Several tools are available on the market for Visual Analytics and Data Discovery.

Can a planet be alive? Lynn Margulis, a giant of late 20th-century biology, who had an incandescent intellect that veered toward the unorthodox, thought so. She and chemist James Lovelock together theorized that life must be a planet-altering phenomenon and the distinction between the "living" and "nonliving" parts of Earth is not as clear-cut as we think. Many members of the scientific community derided their theory, called the Gaia hypothesis, as pseudoscience, and questioned their scientific integrity. But now Margulis and Lovelock may have their revenge. Recent scientific discoveries are giving us reason to take this hypothesis more seriously. At its core is an insight about the relationship between planets and life that has changed our understanding of both, and is shaping how we look for life on other worlds.

Several institutions are embroiled in a legal dispute over the foundational patent rights to CRISPR-Cas9 gene-editing technology, and it may take years for their competing claims to be resolved (1–4). But even before ownership of the patents is finalized, the institutions behind CRISPR have wasted no time capitalizing on the huge market for this groundbreaking technology by entering into a series of license agreements with commercial enterprises (see the figure). With respect to the potentially lucrative market for human therapeutics and treatments, each of the key CRISPR patent holders has granted exclusive rights to a spinoff or "surrogate" company formed by the institution and one of its principal researchers (5, 6). Although this model, in which a university effectively outsources the licensing and commercialization of a valuable patent portfolio to a private company, is not uncommon in the world of university technology transfer, we suggest it could rapidly bottleneck the use of CRISPR technology to discover and develop useful human therapeutics.

This is an image of the Zaamenkomst panel: one of the best remaining exemplars of rock art from the San people of Southern Africa. As soon as you see it, you are inevitably herded, like the eland in the scene, through a series of thoughts. Does it have a meaning? Why are the eland running? What do the white lines coming from the mouths of the humans and animals signify? What event is unfolding in this scene?

Essentially good hypotheses lead decision-makers like you to new and better ways to achieve your business goals. When you need to make decisions such as how much you should spend on advertising or what effect a price increase will have your customer base, it's easy to make wild assumptions or get lost in analysis paralysis. A business hypothesis solves this problem, because, at the start, it's based on some foundational information. In all of science, hypotheses are grounded in theory. Theory tells you what you can generally expect from a certain line of inquiry.