We propose a new approach to formally describing the requirement for statistical inference and checking whether a program uses the statistical method appropriately. Specifically, we define belief Hoare logic (BHL) for formalizing and reasoning about the statistical beliefs acquired via hypothesis testing. This program logic is sound and relatively complete with respect to a Kripke model for hypothesis tests. We demonstrate by examples that BHL is useful for reasoning about practical issues in hypothesis testing. In our framework, we clarify the importance of prior beliefs in acquiring statistical beliefs through hypothesis testing, and discuss the whole picture of the justification of statistical inference inside and outside the program logic.

More than 150,000 adults and children with type 1 diabetes are now eligible to get an'artificial pancreas'. NHS regulators have today approved hybrid closed-loop system technology, which experts say is the'biggest breakthrough since insulin'. The high-tech device continuously tracks blood sugar levels through a sensor stuck to the body. Readings are fed straight back to a body-worn insulin pump, with an algorithm then calculating how much of the hormone needs to be released. An artificial pancreas to manage type 1 diabetes could soon be offered to NHS patients after a major trial produced'blisteringly brilliant' early results.

This paper revisits datasets and evaluation criteria for Symbolic Regression (SR), specifically focused on its potential for scientific discovery. Focused on a set of formulas used in the existing datasets based on Feynman Lectures on Physics, we recreate 120 datasets to discuss the performance of symbolic regression for scientific discovery (SRSD). For each of the 120 SRSD datasets, we carefully review the properties of the formula and its variables to design reasonably realistic sampling ranges of values so that our new SRSD datasets can be used for evaluating the potential of SRSD such as whether or not an SR method can (re)discover physical laws from such datasets. We also create another 120 datasets that contain dummy variables to examine whether SR methods can choose necessary variables only. Besides, we propose to use normalized edit distances (NED) between a predicted equation and the true equation trees for addressing a critical issue that existing SR metrics are either binary or errors between the target values and an SR model's predicted values for a given input. We conduct benchmark experiments on our new SRSD datasets using various representative SR methods. The experimental results show that we provide a more realistic performance evaluation, and our user study shows that the NED correlates with human judges significantly more than an existing SR metric.

We consider the problem of sequential multiple hypothesis testing with nontrivial data collection costs. This problem appears, for example, when conducting biological experiments to identify differentially expressed genes of a disease process. This work builds on the generalized $\alpha$-investing framework which enables control of the false discovery rate in a sequential testing setting. We make a theoretical analysis of the long term asymptotic behavior of $\alpha$-wealth which motivates a consideration of sample size in the $\alpha$-investing decision rule. Posing the testing process as a game with nature, we construct a decision rule that optimizes the expected $\alpha$-wealth reward (ERO) and provides an optimal sample size for each test. Empirical results show that a cost-aware ERO decision rule correctly rejects more false null hypotheses than other methods for $n=1$ where $n$ is the sample size. When the sample size is not fixed cost-aware ERO uses a prior on the null hypothesis to adaptively allocate of the sample budget to each test. We extend cost-aware ERO investing to finite-horizon testing which enables the decision rule to allocate samples in a non-myopic manner. Finally, empirical tests on real data sets from biological experiments show that cost-aware ERO balances the allocation of samples to an individual test against the allocation of samples across multiple tests.

In the upcoming decade, deep learning may revolutionize the natural sciences, enhancing our capacity to model and predict natural occurrences. This could herald a new era of scientific exploration, bringing significant advancements across sectors from drug development to renewable energy. To answer this call, we present DeepSpeed4Science initiative (deepspeed4science.ai) which aims to build unique capabilities through AI system technology innovations to help domain experts to unlock today's biggest science mysteries. By leveraging DeepSpeed's current technology pillars (training, inference and compression) as base technology enablers, DeepSpeed4Science will create a new set of AI system technologies tailored for accelerating scientific discoveries by addressing their unique complexity beyond the common technical approaches used for accelerating generic large language models (LLMs). In this paper, we showcase the early progress we made with DeepSpeed4Science in addressing two of the critical system challenges in structural biology research.

Information value (IV) is a quite popular technique for features selection before the modeling phase. There are practical criteria, based on fixed thresholds for IV, but at the same time mysterious and lacking theoretical arguments, to decide if a predictor has sufficient predictive power to be considered in the modeling phase. However, the mathematical development and statistical inference methods for this technique are almost nonexistent in the literature. In this paper we present a theoretical framework for IV, and at the same time, we propose a non-parametric hypothesis test to evaluate the predictive power of features contemplated in a data set. Due to its relationship with divergence measures developed in the Information Theory, we call our proposal the J - Divergence test. We show how to efficiently compute our test statistic and we study its performance on simulated data. In various scenarios, particularly in unbalanced data sets, we show its superiority over conventional criteria based on fixed thresholds. Furthermore, we apply our test on fraud identification data and provide an open-source Python library, called "statistical-iv"(https://pypi.org/project/statistical-iv/), where we implement our main results.

We apply foundation models to data discovery and exploration tasks. Foundation models are large language models (LLMs) that show promising performance on a range of diverse tasks unrelated to their training. We show that these models are highly applicable to the data discovery and data exploration domain. When carefully used, they have superior capability on three representative tasks: table-class detection, column-type annotation and join-column prediction. On all three tasks, we show that a foundation-model-based approach outperforms the task-specific models and so the state of the art. Further, our approach often surpasses human-expert task performance. We investigate the fundamental characteristics of this approach including generalizability to several foundation models, impact of non-determinism on the outputs and syntactic/semantic signals. All in all, this suggests a future direction in which disparate data management tasks can be unified under foundation models.

The discovery of scientific formulae that parsimoniously explain natural phenomena and align with existing background theory is a key goal in science. Historically, scientists have derived natural laws by manipulating equations based on existing knowledge, forming new equations, and verifying them experimentally. In recent years, data-driven scientific discovery has emerged as a viable competitor in settings with large amounts of experimental data. Unfortunately, data-driven methods often fail to discover valid laws when data is noisy or scarce. Accordingly, recent works combine regression and reasoning to eliminate formulae inconsistent with background theory. However, the problem of searching over the space of formulae consistent with background theory to find one that fits the data best is not well-solved. We propose a solution to this problem when all axioms and scientific laws are expressible via polynomial equalities and inequalities and argue that our approach is widely applicable. We further model notions of minimal complexity using binary variables and logical constraints, solve polynomial optimization problems via mixed-integer linear or semidefinite optimization, and prove the validity of our scientific discoveries in a principled manner using Positivestellensatz certificates. Remarkably, the optimization techniques leveraged in this paper allow our approach to run in polynomial time with fully correct background theory, or non-deterministic polynomial (NP) time with partially correct background theory. We demonstrate that some famous scientific laws, including Kepler's Third Law of Planetary Motion, the Hagen-Poiseuille Equation, and the Radiated Gravitational Wave Power equation, can be derived in a principled manner from background axioms and experimental data.

Dr. Craig Basman discusses new life-saving technology and the variables that can predict sudden cardiac events. Half of those who suffer cardiac arrest experience a telling symptom 24 hours before the incident, according to a study recently published in The Lancet Digital Health journal. This warning symptom was different in men and in women, researchers from Smidt Heart Institute found; the institute is located in the Cedars Sinai Medical Center in Los Angeles. For women, shortness of breath was the symptom that preceded an impending cardiac arrest, while for men, chest pain was the prominent complaint. SKIPPING THE SALT CAN REDUCE HEART DISEASE RISK BY ALMOST 20%, STUDY FINDS: 'KNOW WHAT YOU ARE CONSUMING' Sweating and seizure-like activity occurred in smaller subgroups of both genders, the researchers noted.

Shinobu Yamanaka apologized the moment this reporter arrived for an interview at a day care facility in the city of Konan, Kochi Prefecture, one muggy morning in July. "Sorry, I had completely forgotten about it," she said with a smile at Day Service Happy, a traditional Japanese-style house converted into a day care center for people with dementia and other health conditions in need of nursing care. "I must leave for another appointment at a local elementary school soon." Yamanaka, a vivacious 46-year-old woman who has her short hair dyed ash blonde, has early-onset Alzheimer's. She often has memory lapses like the one that morning, she later confided.