Elucidating the mechanisms of metabolic pathways helps us understand the cascade of enzyme-catalyzed reactions that lead to the conversion of substances into final products. This has implications for predicting how newly synthesized compounds will affect a person's metabolism and, hence, the development of novel treatments to improve one's health. The study of metabolomic pathways, together with protein engineering, may also aid in the extraction, at a scale, of natural products to be used as drugs and drug precursors. Several approaches have been used to correlate protein annotations to metabolic pathways in order to derive pathways directly related to specific organisms. These could range from association rule-mining techniques to machine learning methods such as decision trees, naïve Bayes, logistic regression, and ensemble methods.In this chapter, we will be reviewing the use of machine learning for metabolic pathway analyses, with a step-by-step focus on the use of deep learning to predict the association of compounds (metabolites) to their respective metabolomic pathway classes.

Knowledge graph (KG) embedding techniques use structured relationships between entities to learn low-dimensional representations of entities and relations. The traditional KG embedding techniques (such as TransE and DistMult) estimate these embeddings via simple models developed over observed KG triplets. These approaches differ in their triplet scoring loss functions. As these models only use the observed triplets to estimate the embeddings, they are prone to suffer through data sparsity that usually occurs in the real-world knowledge graphs, i.e., the lack of enough triplets per entity. To settle this issue, we propose an efficient method to augment the number of triplets to address the problem of data sparsity. We use random walks to create additional triplets, such that the relations carried by these introduced triplets entail the metapath induced by the random walks. We also provide approaches to accurately and efficiently filter out informative metapaths from the possible set of metapaths, induced by the random walks. The proposed approaches are model-agnostic, and the augmented training dataset can be used with any KG embedding approach out of the box. Experimental results obtained on the benchmark datasets show the advantages of the proposed approach.

Semi-supervised learning has shown promise in allowing NLP models to generalize from small amounts of labeled data. Meanwhile, pretrained transformer models act as black-box correlation engines that are difficult to explain and sometimes behave unreliably. In this paper, we propose tackling both of these challenges via Automatic Rule Induction (ARI), a simple and general-purpose framework for the automatic discovery and integration of symbolic rules into pretrained transformer models. First, we extract weak symbolic rules from low-capacity machine learning models trained on small amounts of labeled data. Next, we use an attention mechanism to integrate these rules into high-capacity pretrained transformer models. Last, the rule-augmented system becomes part of a self-training framework to boost supervision signal on unlabeled data. These steps can be layered beneath a variety of existing weak supervision and semi-supervised NLP algorithms in order to improve performance and interpretability. Experiments across nine sequence classification and relation extraction tasks suggest that ARI can improve state-of-the-art methods with no manual effort and minimal computational overhead.

Ten years ago, 12-year-old Rory Staunton dove for a ball in gym class and scraped his arm. He woke up the next day with a 104 F fever, so his parents took him to the pediatrician and eventually the emergency room. It was just the stomach flu, they were told. Three days later, Rory died of sepsis after bacteria from the scrape infiltrated his blood and triggered organ failure. "How does that happen in a modern society?" his father, Ciaran Staunton, said in a recent interview with Undark. Each year in the United States, sepsis kills over a quarter million people -- more than stroke, diabetes, or lung cancer.

Creativity, i.e., the process of generating and developing fresh and original ideas or products that are useful or effective, is a valuable skill in a variety of domains. Creativity is called an essential 21st-century skill that should be taught in schools. The use of educational technology to promote creativity is an active study field, as evidenced by several studies linking creativity in the classroom to beneficial learning outcomes. Despite the burgeoning body of research on adaptive technology for education, mining creative thinking patterns from educational data remains a challenging task. In this paper, to address this challenge, we put the first step towards formalizing educational knowledge by constructing a domain-specific Knowledge Base to identify essential concepts, facts, and assumptions in identifying creative patterns. We then introduce a pipeline to contextualize the raw educational data, such as assessments and class activities. Finally, we present a rule-based approach to learning from the Knowledge Base, and facilitate mining creative thinking patterns from contextualized data and knowledge. We evaluate our approach with real-world datasets and highlight how the proposed pipeline can help instructors understand creative thinking patterns from students' activities and assessment tasks.

The understanding of time expressions includes two sub-tasks: recognition and normalization. In recent years, significant progress has been made in the recognition of time expressions while research on normalization has lagged behind. Existing SOTA normalization methods highly rely on rules or grammars designed by experts, which limits their performance on emerging corpora, such as social media texts. In this paper, we model time expression normalization as a sequence of operations to construct the normalized temporal value, and we present a novel method called ARTime, which can automatically generate normalization rules from training data without expert interventions. Specifically, ARTime automatically captures possible operation sequences from annotated data and generates normalization rules on time expressions with common surface forms. The experimental results show that ARTime can significantly surpass SOTA methods on the Tweets benchmark, and achieves competitive results with existing expert-engineered rule methods on the TempEval-3 benchmark.

Being able to train Named Entity Recognition (NER) models for emerging topics is crucial for many real-world applications especially in the medical domain where new topics are continuously evolving out of the scope of existing models and datasets. For a realistic evaluation setup, we introduce a novel COVID-19 news NER dataset (COVIDNEWS-NER) and release 3000 entries of hand annotated strongly labelled sentences and 13000 auto-generated weakly labelled sentences. Besides the dataset, we propose CONTROSTER, a recipe to strategically combine weak and strong labels in improving NER in an emerging topic through transfer learning. We show the effectiveness of CONTROSTER on COVIDNEWS-NER while providing analysis on combining weak and strong labels for training. Our key findings are: (1) Using weak data to formulate an initial backbone before tuning on strong data outperforms methods trained on only strong or weak data. (2) A combination of out-of-domain and in-domain weak label training is crucial and can overcome saturation when being training on weak labels from a single source.

In healthcare, AI systems support clinicians and patients in diagnosis, treatment, and monitoring, but many systems' poor explainability remains challenging for practical application. Overcoming this barrier is the goal of explainable AI (XAI). However, an explanation can be perceived differently and, thus, not solve the black-box problem for everyone. The domain of Human-Centered AI deals with this problem by adapting AI to users. We present a user-centered persona concept to evaluate XAI and use it to investigate end-users preferences for various explanation styles and contents in a mobile health stress monitoring application. The results of our online survey show that users' demographics and personality, as well as the type of explanation, impact explanation preferences, indicating that these are essential features for XAI design. We subsumed the results in three prototypical user personas: power-, casual-, and privacy-oriented users. Our insights bring an interactive, human-centered XAI closer to practical application.

Data-driven decision making is becoming an integral part of manufacturing companies. Data is collected and commonly used to improve efficiency and produce high quality items for the customers. IoT-based and other forms of object tracking are an emerging tool for collecting movement data of objects/entities (e.g. human workers, moving vehicles, trolleys etc.) over space and time. Movement data can provide valuable insights like process bottlenecks, resource utilization, effective working time etc. that can be used for decision making and improving efficiency. Turning movement data into valuable information for industrial management and decision making requires analysis methods. We refer to this process as movement analytics. The purpose of this document is to review the current state of work for movement analytics both in manufacturing and more broadly. We survey relevant work from both a theoretical perspective and an application perspective. From the theoretical perspective, we put an emphasis on useful methods from two research areas: machine learning, and logic-based knowledge representation. We also review their combinations in view of movement analytics, and we discuss promising areas for future development and application. Furthermore, we touch on constraint optimization. From an application perspective, we review applications of these methods to movement analytics in a general sense and across various industries. We also describe currently available commercial off-the-shelf products for tracking in manufacturing, and we overview main concepts of digital twins and their applications.

Making good decisions is a very important part of constructing One way to deal with or preempt failure in such a good Artificial Intelligence (AI). However, there is system is to use preferences and rule-based decisionmaking an important distinction between decision-making itself and (Dietrich and List 2013). For example, in the field reasoning about decision-making, similarly to the distinction of moral reasoning, there is value-based decision-making between (normative) ethics and metaethics. We believe with a rule-based implementation (Badea 2020). The focus more focus in the areas of automated decision-making, anticipatory of such works is generally on the preference ordering on the thinking and cognitive systems ought to be explicitly values (the Representation step we discuss below), or on the given to discussing and deciding upon the characteristics ordering on the rules (the Reasoning step below). We will of good decision-making systems and how best to build use this implementation from (Badea 2020) as a running example them.