Given a specification $\varphi(X,Y)$ over inputs $X$ and output $Y$, defined over a background theory $\mathbb{T}$, the problem of program synthesis is to design a program $f$ such that $Y=f(X)$ satisfies the specification $\varphi$. Over the past decade, syntax-guided synthesis (SyGuS) has emerged as a dominant approach for program synthesis where in addition to the specification $\varphi$, the end-user also specifies a grammar $L$ to aid the underlying synthesis engine. This paper investigates the feasibility of synthesis techniques without grammar, a sub-class defined as $\mathbb{T}$-constrained synthesis. We show that $\mathbb{T}$-constrained synthesis can be reduced to DQF($\mathbb{T}$), i.e., to the problem of finding a witness of a Dependency Quantified Formula Modulo Theory. When the underlying theory is the theory of bitvectors, the corresponding DQF(BV) problem can be further reduced to Dependency Quantified Boolean Formulas (DQBF). We rely on the progress in DQBF solving to design DQBF-based synthesizers that outperform the domain-specific program synthesis techniques, thereby positioning DQBF as a core representation language for program synthesis. Our empirical analysis shows that $\mathbb{T}$-constrained synthesis can achieve significantly better performance than syntax-guided approaches. Furthermore, the general-purpose DQBF solvers perform on par with domain-specific synthesis techniques.

The application of Artificial Intelligence (AI) to synthetic biology will provide the foundation for the creation of a high throughput automated platform for genetic design, in which a learning machine is used to iteratively optimise the system through a design-build-test-learn (DBTL) cycle. However, mainstream machine learning techniques represented by deep learning lacks the capability to represent relational knowledge and requires prodigious amounts of annotated training data. These drawbacks strongly restrict AI's role in synthetic biology in which experimentation is inherently resource and time intensive. In this work, we propose an automated biodesign engineering framework empowered by Abductive Meta-Interpretive Learning ($Meta_{Abd}$), a novel machine learning approach that combines symbolic and sub-symbolic machine learning, to further enhance the DBTL cycle by enabling the learning machine to 1) exploit domain knowledge and learn human-interpretable models that are expressed by formal languages such as first-order logic; 2) simultaneously optimise the structure and parameters of the models to make accurate numerical predictions; 3) reduce the cost of experiments and effort on data annotation by actively generating hypotheses and examples. To verify the effectiveness of $Meta_{Abd}$, we have modelled a synthetic dataset for the production of proteins from a three gene operon in a microbial host, which represents a common synthetic biology problem.

In the meantime, a wide variety of terminologies, motivations, approaches and evaluation criteria have been developed within the scope of research on explainable artificial intelligence (XAI). Many taxonomies can be found in the literature, each with a different focus, but also showing many points of overlap. In this paper, we summarize the most cited and current taxonomies in a meta-analysis in order to highlight the essential aspects of the state-of-the-art in XAI. We also present and add terminologies as well as concepts from a large number of survey articles on the topic. Last but not least, we illustrate concepts from the higher-level taxonomy with more than 50 example methods, which we categorize accordingly, thus providing a wide-ranging overview of aspects of XAI and paving the way for use case-appropriate as well as context-specific subsequent research.

In this paper, we provide simplified semantics for the logic K45(G), i.e. the many-valued Godel counterpart of the classical modal logic K45. More precisely, we characterize K45(G) as the set of valid formulae of the class of possibilistic Godel Kripke Frames where W is a non-empty set of worlds and \pi: W \to [0, 1] is a possibility distribution on W.

Topological Spatial Model Checking is a recent paradigm that combines Model Checking with the topological interpretation of Modal Logic. The Spatial Logic of Closure Spaces, SLCS, extends Modal Logic with reachability connectives that, in turn, can be used for expressing interesting spatial properties, such as "being near to" or "being surrounded by". SLCS constitutes the kernel of a solid logical framework for reasoning about discrete space, such as graphs and digital images, interpreted as quasi discrete closure spaces. In particular, the spatial model checker VoxLogicA, that uses an extended version of SLCS, has been used successfully in the domain of medical imaging. However, SLCS is not restricted to discrete space. Following a recently developed geometric semantics of Modal Logic, we show that it is possible to assign an interpretation to SLCS in continuous space, admitting a model checking procedure, by resorting to models based on polyhedra. In medical imaging such representations of space are increasingly relevant, due to recent developments of 3D scanning and visualisation techniques that exploit mesh processing. We demonstrate feasibility of our approach via a new tool, PolyLogicA, aimed at efficient verification of SLCS formulas on polyhedra, while inheriting some well-established optimization techniques already adopted in VoxLogicA. Finally, we cater for a geometric definition of bisimilarity, proving that it characterises logical equivalence.

Recent work has unveiled a theory for reasoning about the decisions made by binary classifiers: a classifier describes a Boolean function, and the reasons behind an instance being classified as positive are the prime-implicants of the function that are satisfied by the instance. One drawback of these works is that they do not explicitly treat scenarios where the underlying data is known to be constrained, e.g., certain combinations of features may not exist, may not be observable, or may be required to be disregarded. We propose a more general theory, also based on prime-implicants, tailored to taking constraints into account. The main idea is to view classifiers in the presence of constraints as describing partial Boolean functions, i.e., that are undefined on instances that do not satisfy the constraints. We prove that this simple idea results in reasons that are no less (and sometimes more) succinct. That is, not taking constraints into account (e.g., ignored, or taken as negative instances) results in reasons that are subsumed by reasons that do take constraints into account. We illustrate this improved parsimony on synthetic classifiers and classifiers learned from real data.

Neuro-Symbolic Artificial Intelligence -- the combination of symbolic methods with methods that are based on artificial neural networks -- has a long-standing history. In this article, we provide a structured overview of current trends, by means of categorizing recent publications from key conferences. The article is meant to serve as a convenient starting point for research on the general topic.

Geometry problem solving has attracted much attention in the NLP community recently. The task is challenging as it requires abstract problem understanding and symbolic reasoning with axiomatic knowledge. However, current datasets are either small in scale or not publicly available. Thus, we construct a new large-scale benchmark, Geometry3K, consisting of 3,002 geometry problems with dense annotation in formal language. We further propose a novel geometry solving approach with formal language and symbolic reasoning, called Interpretable Geometry Problem Solver (Inter-GPS). Inter-GPS first parses the problem text and diagram into formal language automatically via rule-based text parsing and neural object detecting, respectively. Unlike implicit learning in existing methods, Inter-GPS incorporates theorem knowledge as conditional rules and performs symbolic reasoning step by step. A theorem predictor is also designed to infer the theorem application sequence fed to the symbolic solver for the more efficient and reasonable searching path. Extensive experiments on the Geometry3K and GEOS datasets demonstrate Inter-GPS achieves significant improvements over existing methods.

We assume that the values of propositional variables are not defined Discounting future costs and rewards is a common in the terminal state t. The agent a has multiple actions in practice in accounting, game theory, and machine each game state. These actions are depicted in Figure 1 using learning. In spite of this, existing logics for reasoning directed edges. The cost of each action to agent a is shown as about strategies with cost and resource constraints a label on the directed edge. For instance, the directed edge do not account for discounting. The paper from state w to state u with label 2 means that the agent a proposes a sound and complete logical system for has an action with cost 2 to transition the game from state w reasoning about budget-constrained strategic abilities to state u. Transitioning to the terminal state t represents the that incorporates discounting into its semantics.

The Operating Room Scheduling (ORS) problem is the task of assigning patients to operating rooms, taking into account different specialties, lengths and priority scores of each planned surgery, operating room session durations, and the availability of beds for the entire length of stay both in the Intensive Care Unit and in the wards. A proper solution to the ORS problem is of primary importance for the healthcare service quality and the satisfaction of patients in hospital environments. In this paper we first present a solution to the problem based on Answer Set Programming (ASP). The solution is tested on benchmarks with realistic sizes and parameters, on three scenarios for the target length on 5-day scheduling, common in small-medium sized hospitals, and results show that ASP is a suitable solving methodology for the ORS problem in such setting. Then, we also performed a scalability analysis on the schedule length up to 15 days, which still shows the suitability of our solution also on longer plan horizons. Moreover, we also present an ASP solution for the rescheduling problem, i.e. when the off-line schedule cannot be completed for some reason. Finally, we introduce a web framework for managing ORS problems via ASP that allows a user to insert the main parameters of the problem, solve a specific instance, and show results graphically in real-time.