The team at Charité – Universitätsmedizin Berlin, TU Berlin, and the University of Oslo, have developed the system that, for the first time, integrates morphological, molecular, and histological data in a single analysis. The system also provides a clarification of the AI decision process in the form of heatmaps. The heatmaps show which visual information influenced the AI decision process and to what extent, which enables doctors to understand and assess the plausibility of the results – representing an essential step forward for the future use of AI systems in hospitals. The research has been published in Nature Machine Intelligence. The molecular characterisation of tumour tissue samples is becoming increasingly important for cancer treatment, with studies being conducted to determine changes to DNA as well as the gene and protein expression in the samples.

Universitätsmedizin Berlin and TU Berlin as well as the University of Oslo have developed a new tissue-section analysis system for diagnosing breast cancer based on artificial intelligence (AI). Two further developments make this system unique: For the first time, morphological, molecular and histological data are integrated in a single analysis. Secondly, the system provides a clarification of the AI decision process in the form of heatmaps. Pixel by pixel, these heatmaps show which visual information influenced the AI decision process and to what extent, thus enabling doctors to understand and assess the plausibility of the results of the AI analysis. This represents a decisive and essential step forward for the future regular use of AI systems in hospitals. The results of this research have now been published in Nature Machine Intelligence.

Data privacy concerns often prevent the use of cloud-based machine learning services for sensitive personal data. While homomorphic encryption (HE) offers a potential solution by enabling computations on encrypted data, the challenge is to obtain accurate machine learning models that work within the multiplicative depth constraints of a leveled HE scheme. Existing approaches for encrypted inference either make ad-hoc simplifications to a pre-trained model (e.g., replace hard comparisons in a decision tree with soft comparators) at the cost of accuracy or directly train a new depth-constrained model using the original training set. In this work, we propose a framework to transfer knowledge extracted by complex decision tree ensembles to shallow neural networks (referred to as DTNets) that are highly conducive to encrypted inference. Our approach minimizes the accuracy loss by searching for the best DTNet architecture that operates within the given depth constraints and training this DTNet using only synthetic data sampled from the training data distribution. Extensive experiments on real-world datasets demonstrate that these characteristics are critical in ensuring that DTNet accuracy approaches that of the original tree ensemble. Our system is highly scalable and can perform efficient inference on batched encrypted (134 bits of security) data with amortized time in milliseconds. This is approximately three orders of magnitude faster than the standard approach of applying soft comparison at the internal nodes of the ensemble trees.

The decision tree Algorithm belongs to the family of supervised machine learning algorithms. It can be used for both a classification problem as well as for regression problem. The goal of this algorithm is to create a model that predicts the value of a target variable, for which the decision tree uses the tree representation to solve the problem in which the leaf node corresponds to a class label and attributes are represented on the internal node of the tree. It will split our data into two branches High and Normal based on cholesterol, as you can see in the above figure. Let's suppose our new patient has high cholesterol by the above split of our data we cannot say whether Drug B or Drug A will be suitable for the patient.

Constraint-based recommenders support users in the identification of items (products) fitting their wishes and needs. Example domains are financial services and electronic equipment. In this paper we show how divide-and-conquer based (direct) diagnosis algorithms (no conflict detection is needed) can be exploited in constraint-based recommendation scenarios. In this context, we provide an overview of the MediaWiki-based recommendation environment WeeVis.

The monitoring of rotating machinery is an essential task in today's production processes. Currently, several machine learning and deep learning-based modules have achieved excellent results in fault detection and diagnosis. Nevertheless, to further increase user adoption and diffusion of such technologies, users and human experts must be provided with explanations and insights by the modules. Another issue is related, in most cases, with the unavailability of labeled historical data that makes the use of supervised models unfeasible. Therefore, a new approach for fault detection and diagnosis in rotating machinery is here proposed. The methodology consists of three parts: feature extraction, fault detection and fault diagnosis. In the first part, the vibration features in the time and frequency domains are extracted. Secondly, in the fault detection, the presence of fault is verified in an unsupervised manner based on anomaly detection algorithms. The modularity of the methodology allows different algorithms to be implemented. Finally, in fault diagnosis, Shapley Additive Explanations (SHAP), a technique to interpret black-box models, is used. Through the feature importance ranking obtained by the model explainability, the fault diagnosis is performed. Two tools for diagnosis are proposed, namely: unsupervised classification and root cause analysis. The effectiveness of the proposed approach is shown on three datasets containing different mechanical faults in rotating machinery. The study also presents a comparison between models used in machine learning explainability: SHAP and Local Depth-based Feature Importance for the Isolation Forest (Local- DIFFI). Lastly, an analysis of several state-of-art anomaly detection algorithms in rotating machinery is included.

With the development of computer-aided diagnosis (CAD) and image scanning technology, Whole-slide Image (WSI) scanners are widely used in the field of pathological diagnosis. Therefore, WSI analysis has become the key to modern digital pathology. Since 2004, WSI has been used more and more in CAD. Since machine vision methods are usually based on semi-automatic or fully automatic computers, they are highly efficient and labor-saving. The combination of WSI and CAD technologies for segmentation, classification, and detection helps histopathologists obtain more stable and quantitative analysis results, save labor costs and improve diagnosis objectivity. This paper reviews the methods of WSI analysis based on machine learning. Firstly, the development status of WSI and CAD methods are introduced. Secondly, we discuss publicly available WSI datasets and evaluation metrics for segmentation, classification, and detection tasks. Then, the latest development of machine learning in WSI segmentation, classification, and detection are reviewed continuously. Finally, the existing methods are studied, the applicabilities of the analysis methods are analyzed, and the application prospects of the analysis methods in this field are forecasted.

Check out our gradient descent tutorial. A decision tree is a vital and popular tool for classification and prediction problems in machine learning, statistics, data mining, and machine learning [4]. It describes rules that can be interpreted by humans and applied in a knowledge system such as databases. It classifies cases by commencing at the tree's root and passing through it unto a leaf node. A decision tree uses nodes and leaves to make a decision.

Many domains require scalable algorithms that help to determine diagnoses efficiently and often within predefined time limits. Anytime diagnosis is able to determine solutions in such a way and thus is especially useful in real-time scenarios such as production scheduling, robot control, and communication networks management where diagnosis and corresponding reconfiguration capabilities play a major role. Anytime diagnosis in many cases comes along with a trade-off between diagnosis quality and the efficiency of diagnostic reasoning. In this paper we introduce and analyze FlexDiag which is an anytime direct diagnosis approach. We evaluate the algorithm with regard to performance and diagnosis quality using a configuration benchmark from the domain of feature models and an industrial configuration knowledge base from the automotive domain. Results show that FlexDiag helps to significantly increase the performance of direct diagnosis search with corresponding quality tradeoffs in terms of minimality and accuracy.

Constraint sets can become inconsistent in different contexts. For example, during a configuration session the set of customer requirements can become inconsistent with the configuration knowledge base. Another example is the engineering phase of a configuration knowledge base where the underlying constraints can become inconsistent with a set of test cases. In such situations we are in the need of techniques that support the identification of minimal sets of faulty constraints that have to be deleted in order to restore consistency. In this paper we introduce a divide-and-conquer based diagnosis algorithm (FastDiag) which identifies minimal sets of faulty constraints in an over-constrained problem. This algorithm is specifically applicable in scenarios where the efficient identification of leading (preferred) diagnoses is crucial. We compare the performance of FastDiag with the conflict-directed calculation of hitting sets and present an in-depth performance analysis that shows the advantages of our approach.