This paper proposes a framework based on a causal model of safety upon which effective safety assurance cases for ML-based applications can be developed. In doing so, we build upon established principles of safety engineering as well as previous work on structuring assurance arguments for ML. The paper defines four categories of safety case evidence and a structured analysis approach within which these evidences can be effectively combined. Where appropriate, abstract formalisations of these contributions are used to illustrate the causalities they evaluate, their contributions to the safety argument and desirable properties of the evidences. Based on the proposed framework, progress in this area is re-evaluated and a set of future research directions proposed in order for tangible progress in this field to be made.

Cancer is one of the leading causes of death worldwide. Fast and safe early-stage, pre- and intra-operative diagnostics can significantly contribute to successful cancer identification and treatment. Artificial intelligence has played an increasing role in the enhancement of cancer diagnostics techniques in the last 15 years. This review covers the advances of artificial intelligence applications in well-established techniques such as MRI and CT. Also, it shows its high potential in combination with optical spectroscopy-based approaches that are under development for mobile, ultra-fast, and low-invasive diagnostics. I will show how spectroscopy-based approaches can reduce the time of tissue preparation for pathological analysis by making thin-slicing or haematoxylin-and-eosin staining obsolete. I will present examples of spectroscopic tools for fast and low-invasive ex- and in-vivo tissue classification for the determination of a tumour and its boundaries. Also, I will discuss that, contrary to MRI and CT, spectroscopic measurements do not require the administration of chemical agents to enhance the quality of cancer imaging which contributes to the development of more secure diagnostic methods. Overall, we will see that the combination of spectroscopy and artificial intelligence constitutes a highly promising and fast-developing field of medical technology that will soon augment available cancer diagnostic methods.

Bearing fault diagnosis is of great importance to decrease the damage risk of rotating machines and further improve economic profits. Recently, machine learning, represented by deep learning, has made great progress in bearing fault diagnosis. However, applying deep learning to such a task still faces a major problem. A deep network is notoriously a black box. It is difficult to know how a model classifies faulty signals from the normal and the physics principle behind the classification. To solve the interpretability issue, first, we prototype a convolutional network with recently-invented quadratic neurons. This quadratic neuron empowered network can qualify the noisy bearing data due to the strong feature representation ability of quadratic neurons. Moreover, we independently derive the attention mechanism from a quadratic neuron, referred to as qttention, by factorizing the learned quadratic function in analogue to the attention, making the model with quadratic neurons inherently interpretable. Experiments on the public and our datasets demonstrate that the proposed network can facilitate effective and interpretable bearing fault diagnosis.

Causal relationships are commonly examined in manufacturing processes to support faults investigations, perform interventions, and make strategic decisions. Industry 4.0 has made available an increasing amount of data that enable data-driven Causal Discovery (CD). Considering the growing number of recently proposed CD methods, it is necessary to introduce strict benchmarking procedures on publicly available datasets since they represent the foundation for a fair comparison and validation of different methods. This work introduces two novel public datasets for CD in continuous manufacturing processes. The first dataset employs the well-known Tennessee Eastman simulator for fault detection and process control. The second dataset is extracted from an ultra-processed food manufacturing plant, and it includes a description of the plant, as well as multiple ground truths. These datasets are used to propose a benchmarking procedure based on different metrics and evaluated on a wide selection of CD algorithms. This work allows testing CD methods in realistic conditions enabling the selection of the most suitable method for specific target applications. The datasets are available at the following link: https://github.com/giovanniMen

Working with causal models at different levels of abstraction is an important feature of science. Existing work has already considered the problem of expressing formally the relation of abstraction between causal models. In this paper, we focus on the problem of learning abstractions. We start by defining the learning problem formally in terms of the optimization of a standard measure of consistency. We then point out the limitation of this approach, and we suggest extending the objective function with a term accounting for information loss. We suggest a concrete measure of information loss, and we illustrate its contribution to learning new abstractions.

Scottish and European health researchers have announced that they are part of a €6m international project to use AI to improve the diagnosis of bowel cancer, the UK's second-most deadly type of cancer. Bowel cancer is the second most-common cause of cancer death in Scotland, with around 1,600 people dying of the disease each year. The current detection method involves inserting an endoscope, a thin flexible tube with a camera on the end, into a patient's colon which then travels around the large bowel allowing doctors to check for cancer. The new procedure being developed by the research team - known as a Clinical Capsule Endoscopy (CCE) – utilises an artificial intelligence-assisted'smart pill' containing cameras (pictured below) which, once swallowed by a patient, records images of the intestines as it passes through. At present, images captured by the capsules are reviewed by trained doctors, but AI offers the potential to safely and ethically speed up the process, make it more cost-effective and increase its use.

This work proposes a taxonomy for diagnosis computation methods which allows their standardized assessment, classification and comparison. The aim is to (i) give researchers and practitioners an impression of the diverse landscape of available diagnostic techniques, (ii) allow them to easily retrieve the main features as well as pros and cons of the approaches, (iii) enable an easy and clear comparison of the techniques based on their characteristics wrt. a list of important and well-defined properties, and (iv) facilitate the selection of the "right" algorithm to adopt for a particular problem case, e.g., in practical diagnostic settings, for comparison in experimental evaluations, or for reuse, modification, extension, or improvement in the course of research.

Automated segmentation and volumetry of brain magnetic resonance imaging (MRI) scans are essential for the diagnosis of Parkinson's disease (PD) and Parkinson's plus syndromes (P-plus). To enhance the diagnostic performance, we adopt deep learning (DL) models in brain segmentation and compared their performance with the gold-standard non-DL method. We collected brain MRI scans of healthy controls (n=105) and patients with PD (n=105), multiple systemic atrophy (n=132), and progressive supranuclear palsy (n=69) at Samsung Medical Center from January 2017 to December 2020. Using the gold-standard non-DL model, FreeSurfer (FS), we segmented six brain structures: midbrain, pons, caudate, putamen, pallidum, and third ventricle, and considered them as annotating data for DL models, the representative V-Net and UNETR. The Dice scores and area under the curve (AUC) for differentiating normal, PD, and P-plus cases were calculated. The segmentation times of V-Net and UNETR for the six brain structures per patient were 3.48 +- 0.17 and 48.14 +- 0.97 s, respectively, being at least 300 times faster than FS (15,735 +- 1.07 s). Dice scores of both DL models were sufficiently high (>0.85), and their AUCs for disease classification were superior to that of FS. For classification of normal vs. P-plus and PD vs. multiple systemic atrophy (cerebellar type), the DL models and FS showed AUCs above 0.8. DL significantly reduces the analysis time without compromising the performance of brain segmentation and differential diagnosis. Our findings may contribute to the adoption of DL brain MRI segmentation in clinical settings and advance brain research.

New operating conditions can result in a significant performance drop of fault diagnostics models due to the domain shift between the training and the testing data distributions. While several domain adaptation approaches have been proposed to overcome such domain shifts, their application is limited if the fault classes represented in the two domains are not the same. To enable a better transferability of the trained models between two different domains, particularly in setups where only the healthy data class is shared between the two domains, we propose a new framework for Partial and Open-Partial domain adaptation based on generating distinct fault signatures with a Wasserstein GAN. The main contribution of the proposed framework is the controlled synthetic fault data generation with two main distinct characteristics. Firstly, the proposed methodology enables to generate unobserved fault types in the target domain by having only access to the healthy samples in the target domain and faulty samples in the source domain. Secondly, the fault generation can be controlled to precisely generate distinct fault types and fault severity levels. The proposed method is especially suited in extreme domain adaption settings that are particularly relevant in the context of complex and safety-critical systems, where only one class is shared between the two domains. We evaluate the proposed framework on Partial as well as Open-Partial domain adaptation tasks on two bearing fault diagnostics case studies. Our experiments conducted in different label space settings showcase the versatility of the proposed framework. The proposed methodology provided superior results compared to other methods given large domain gaps.

With global cybercrime costs expected to reach $10.5 trillion annually by 2025, according to Cybersecurity Ventures, it comes as little surprise that the risk of attack is companies' biggest concern globally. To help businesses uncover and fix the vulnerabilities and misconfigurations affecting their systems, there is an (over)abundance of solutions available. But beware, they may not give you a full and continuous view of your weaknesses if used in isolation. With huge financial gains to be had from each successful breach, hackers do not rest in their hunt for flaws and use a wide range of tools and scanners to help them in their search. Beating these criminals means staying one step ahead and using the most comprehensive and responsive vulnerability detection support you can.