SARS-CoV-2, the highly contagious pathogen responsible for the COVID-19 pandemic, has persistent effects that begin four weeks after initial infection and last for an undetermined duration. These chronic effects are more harmful than acute ones. This review explores the long-term impact of the virus on various human organs, including the pulmonary, cardiovascular, neurological, reproductive, gastrointestinal, musculoskeletal, endocrine, and lymphoid systems, particularly in older adults. Regarding diagnosis, RT-PCR is the gold standard for detecting COVID-19, though it requires specialized equipment, skilled personnel, and considerable time to produce results. To address these limitations, artificial intelligence in imaging and microfluidics technologies offers promising alternatives for diagnosing COVID-19 efficiently. Pharmacological and non-pharmacological strategies are effective in mitigating the persistent impacts of COVID-19. These strategies enhance immunity in post-COVID-19 patients by reducing cytokine release syndrome, improving T cell response, and increasing the circulation of activated natural killer and CD8 T cells in blood and tissues. This, in turn, alleviates symptoms such as fever, nausea, fatigue, muscle weakness, and pain. Vaccines, including inactivated viral, live attenuated viral, protein subunit, viral vectored, mRNA, DNA, and nanoparticle vaccines, significantly reduce the adverse long-term effects of the virus. However, no vaccine has been reported to provide lifetime protection against COVID-19. Consequently, protective measures such as physical distancing, mask usage, and hand hygiene remain essential strategies. This review offers a comprehensive understanding of the persistent effects of COVID-19 on individuals of varying ages, along with insights into diagnosis, treatment, vaccination, and future preventative measures against the spread of SARS-CoV-2.

The need for modelling causal knowledge at different levels of granularity arises in several settings. Causal Abstraction provides a framework for formalizing this problem by relating two Structural Causal Models at different levels of detail. Despite increasing interest in applying causal abstraction, e.g. in the interpretability of large machine learning models, the graphical and parametrical conditions under which a causal model can abstract another are not known. Furthermore, learning causal abstractions from data is still an open problem. In this work, we tackle both issues for linear causal models with linear abstraction functions. First, we characterize how the low-level coefficients and the abstraction function determine the high-level coefficients and how the high-level model constrains the causal ordering of low-level variables. Then, we apply our theoretical results to learn high-level and low-level causal models and their abstraction function from observational data. In particular, we introduce Abs-LiNGAM, a method that leverages the constraints induced by the learned high-level model and the abstraction function to speedup the recovery of the larger low-level model, under the assumption of non-Gaussian noise terms. In simulated settings, we show the effectiveness of learning causal abstractions from data and the potential of our method in improving scalability of causal discovery.

Modern industrial fault diagnosis tasks often face the combined challenge of distribution discrepancy and bi-imbalance. Existing domain adaptation approaches pay little attention to the prevailing bi-imbalance, leading to poor domain adaptation performance or even negative transfer. In this work, we propose a self-degraded contrastive domain adaptation (Sd-CDA) diagnosis framework to handle the domain discrepancy under the bi-imbalanced data. It first pre-trains the feature extractor via imbalance-aware contrastive learning based on model pruning to learn the feature representation efficiently in a self-supervised manner. Then it forces the samples away from the domain boundary based on supervised contrastive domain adversarial learning (SupCon-DA) and ensures the features generated by the feature extractor are discriminative enough. Furthermore, we propose the pruned contrastive domain adversarial learning (PSupCon-DA) to pay automatically re-weighted attention to the minorities to enhance the performance towards bi-imbalanced data. We show the superiority of the proposed method via two experiments.

Linear non-Gaussian causal models postulate that each random variable is a linear function of parent variables and non-Gaussian exogenous error terms. We study identification of the linear coefficients when such models contain latent variables. Our focus is on the commonly studied acyclic setting, where each model corresponds to a directed acyclic graph (DAG). For this case, prior literature has demonstrated that connections to overcomplete independent component analysis yield effective criteria to decide parameter identifiability in latent variable models. However, this connection is based on the assumption that the observed variables linearly depend on the latent variables. Departing from this assumption, we treat models that allow for arbitrary non-linear latent confounding. Our main result is a graphical criterion that is necessary and sufficient for deciding the generic identifiability of direct causal effects. Moreover, we provide an algorithmic implementation of the criterion with a run time that is polynomial in the number of observed variables. Finally, we report on estimation heuristics based on the identification result, explore a generalization to models with feedback loops, and provide new results on the identifiability of the causal graph.

Industrial equipment fault diagnosis often encounter challenges such as the scarcity of fault data, complex operating conditions, and varied types of failures. Signal analysis, data statistical learning, and conventional deep learning techniques face constraints under these conditions due to their substantial data requirements and the necessity for transfer learning to accommodate new failure modes. To effectively leverage information and extract the intrinsic characteristics of faults across different domains under limited sample conditions, this paper introduces a fault diagnosis approach employing Multi-Scale Graph Convolution Filtering (MSGCF). MSGCF enhances the traditional Graph Neural Network (GNN) framework by integrating both local and global information fusion modules within the graph convolution filter block. This advancement effectively mitigates the over-smoothing issue associated with excessive layering of graph convolutional layers while preserving a broad receptive field. It also reduces the risk of overfitting in few-shot diagnosis, thereby augmenting the model's representational capacity. Experiments on the University of Paderborn bearing dataset (PU) demonstrate that the MSGCF method proposed herein surpasses alternative approaches in accuracy, thereby offering valuable insights for industrial fault diagnosis in few-shot learning scenarios.

In the emergency department (ED), patients undergo triage and multiple laboratory tests before diagnosis. This time-consuming process causes ED crowding which impacts patient mortality, medical errors, staff burnout, etc. This work proposes (time) cost-effective diagnostic assistance that leverages artificial intelligence systems to help ED clinicians make efficient and accurate diagnoses. In collaboration with ED clinicians, we use public patient data to curate MIMIC-ED-Assist, a benchmark for AI systems to suggest laboratory tests that minimize wait time while accurately predicting critical outcomes such as death. With MIMIC-ED-Assist, we develop ED-Copilot which sequentially suggests patient-specific laboratory tests and makes diagnostic predictions. ED-Copilot employs a pre-trained bio-medical language model to encode patient information and uses reinforcement learning to minimize ED wait time and maximize prediction accuracy. On MIMIC-ED-Assist, ED-Copilot improves prediction accuracy over baselines while halving average wait time from four hours to two hours. ED-Copilot can also effectively personalize treatment recommendations based on patient severity, further highlighting its potential as a diagnostic assistant. Since MIMIC-ED-Assist is a retrospective benchmark, ED-Copilot is restricted to recommend only observed tests. We show ED-Copilot achieves competitive performance without this restriction as the maximum allowed time increases. Our code is available at https://github.com/cxcscmu/ED-Copilot.

The unique challenges posed by the space environment, characterized by extreme conditions and limited accessibility, raise the need for robust and reliable techniques to identify and prevent satellite faults. Fault detection methods in the space sector are required to ensure mission success and to protect valuable assets. In this context, this paper proposes an Artificial Intelligence (AI) based fault detection methodology and evaluates its performance on ADAPT (Advanced Diagnostics and Prognostics Testbed), an Electrical Power System (EPS) dataset, crafted in laboratory by NASA. Our study focuses on the application of a physics-informed (PI) real-valued non-volume preserving (Real NVP) model for fault detection in space systems. The efficacy of this method is systematically compared against other AI approaches such as Gated Recurrent Unit (GRU) and Autoencoder-based techniques. Results show that our physics-informed approach outperforms existing methods of fault detection, demonstrating its suitability for addressing the unique challenges of satellite EPS sub-system faults. Furthermore, we unveil the competitive advantage of physics-informed loss in AI models to address specific space needs, namely robustness, reliability, and power constraints, crucial for space exploration and satellite missions.

In the real world, data is often noisy, affecting not only the quality of features but also the accuracy of labels. Current research on mitigating label errors stems primarily from advances in deep learning, and a gap exists in exploring interpretable models, particularly those rooted in decision trees. In this study, we investigate whether ideas from deep learning loss design can be applied to improve the robustness of decision trees. In particular, we show that loss correction and symmetric losses, both standard approaches, are not effective. We argue that other directions need to be explored to improve the robustness of decision trees to label noise.

Unsupervised fault detection in multivariate time series is critical for maintaining the integrity and efficiency of complex systems, with current methodologies largely focusing on statistical and machine learning techniques. However, these approaches often rest on the assumption that data distributions conform to Gaussian models, overlooking the diversity of patterns that can manifest in both normal and abnormal states, thereby diminishing discriminative performance. Our innovation addresses this limitation by introducing a combination of data augmentation and soft contrastive learning, specifically designed to capture the multifaceted nature of state behaviors more accurately. The data augmentation process enriches the dataset with varied representations of normal states, while soft contrastive learning fine-tunes the model's sensitivity to the subtle differences between normal and abnormal patterns, enabling it to recognize a broader spectrum of anomalies. This dual strategy significantly boosts the model's ability to distinguish between normal and abnormal states, leading to a marked improvement in fault detection performance across multiple datasets and settings, thereby setting a new benchmark for unsupervised fault detection in complex systems. The code of our method is available at \url{https://github.com/zangzelin/code_USD.git}.

Unsupervised domain adaptation (UDA) has achieved remarkable success in fault diagnosis, bringing significant benefits to diverse industrial applications. While most UDA methods focus on cross-working condition scenarios where the source and target domains are notably similar, real-world applications often grapple with severe domain shifts. We coin the term `distant domain adaptation problem' to describe the challenge of adapting from a labeled source domain to a significantly disparate unlabeled target domain. This problem exhibits the risk of negative transfer, where extraneous knowledge from the source domain adversely affects the target domain performance. Unfortunately, conventional UDA methods often falter in mitigating this negative transfer, leading to suboptimal performance. In response to this challenge, we propose a novel Online Selective Adversarial Alignment (OSAA) approach. Central to OSAA is its ability to dynamically identify and exclude distant source samples via an online gradient masking approach, focusing primarily on source samples that closely resemble the target samples. Furthermore, recognizing the inherent complexities in bridging the source and target domains, we construct an intermediate domain to act as a transitional domain and ease the adaptation process. Lastly, we develop a class-conditional adversarial adaptation to address the label distribution disparities while learning domain invariant representation to account for potential label distribution disparities between the domains. Through detailed experiments and ablation studies on two real-world datasets, we validate the superior performance of the OSAA method over state-of-the-art methods, underscoring its significant utility in practical scenarios with severe domain shifts.