The need for improved diagnostic methods in ophthalmology is acute, especially in the less developed regions with limited access to specialists and advanced equipment. Therefore, we introduce VisionUnite, a novel vision-language foundation model for ophthalmology enhanced with clinical knowledge. VisionUnite has been pretrained on an extensive dataset comprising 1.24 million image-text pairs, and further refined using our proposed MMFundus dataset, which includes 296,379 high-quality fundus image-text pairs and 889,137 simulated doctor-patient dialogue instances. Our experiments indicate that VisionUnite outperforms existing generative foundation models such as GPT-4V and Gemini Pro. It also demonstrates diagnostic capabilities comparable to junior ophthalmologists. VisionUnite performs well in various clinical scenarios including open-ended multi-disease diagnosis, clinical explanation, and patient interaction, making it a highly versatile tool for initial ophthalmic disease screening. VisionUnite can also serve as an educational aid for junior ophthalmologists, accelerating their acquisition of knowledge regarding both common and rare ophthalmic conditions. VisionUnite represents a significant advancement in ophthalmology, with broad implications for diagnostics, medical education, and understanding of disease mechanisms.

Machine learning systems deployed in safety-critical robotics settings must be robust to distribution shifts. However, system designers must understand the cause of a distribution shift in order to implement the appropriate intervention or mitigation strategy and prevent system failure. In this paper, we present a novel framework for diagnosing distribution shifts in a streaming fashion by deploying multiple stochastic martingales simultaneously. We show that knowledge of the underlying cause of a distribution shift can lead to proper interventions over the lifecycle of a deployed system. Our experimental framework can easily be adapted to different types of distribution shifts, models, and datasets. We find that our method outperforms existing work on diagnosing distribution shifts in terms of speed, accuracy, and flexibility, and validate the efficiency of our model in both simulated and live hardware settings.

Artificial intelligence (AI) is rapidly advancing in healthcare, enhancing the efficiency and effectiveness of services across various specialties, including cardiology, ophthalmology, dermatology, emergency medicine, etc. AI applications have significantly improved diagnostic accuracy, treatment personalization, and patient outcome predictions by leveraging technologies such as machine learning, neural networks, and natural language processing. However, these advancements also introduce substantial ethical and fairness challenges, particularly related to biases in data and algorithms. These biases can lead to disparities in healthcare delivery, affecting diagnostic accuracy and treatment outcomes across different demographic groups. This survey paper examines the integration of AI in healthcare, highlighting critical challenges related to bias and exploring strategies for mitigation. We emphasize the necessity of diverse datasets, fairness-aware algorithms, and regulatory frameworks to ensure equitable healthcare delivery. The paper concludes with recommendations for future research, advocating for interdisciplinary approaches, transparency in AI decision-making, and the development of innovative and inclusive AI applications.

In the domain of rotating machinery, bearings are vulnerable to different mechanical faults, including ball, inner, and outer race faults. Various techniques can be used in condition-based monitoring, from classical signal analysis to deep learning methods. Based on the complex working conditions of rotary machines, multivariate statistical process control charts such as Hotelling's $T^2$ and Squared Prediction Error are useful for providing early warnings. However, these methods are rarely applied to condition monitoring of rotating machinery due to the univariate nature of the datasets. In the present paper, we propose a multivariate statistical process control-based fault detection method that utilizes multivariate data composed of Fourier transform features extracted for fixed-time batches. Our approach makes use of the multidimensional nature of Fourier transform characteristics, which record more detailed information about the machine's status, in an effort to enhance early defect detection and diagnosis. Experiments with varying vibration measurement locations (Fan End, Drive End), fault types (ball, inner, and outer race faults), and motor loads (0-3 horsepower) are used to validate the suggested approach. The outcomes illustrate our method's effectiveness in fault detection and point to possible broader uses in industrial maintenance.

Unsupervised Domain Adaptation (UDA) has emerged as a key solution in data-driven fault diagnosis, addressing domain shift where models underperform in changing environments. However, under the realm of continually changing environments, UDA tends to underperform on previously seen domains when adapting to new ones - a problem known as catastrophic forgetting. To address this limitation, we introduce the EverAdapt framework, specifically designed for continuous model adaptation in dynamic environments. Central to EverAdapt is a novel Continual Batch Normalization (CBN), which leverages source domain statistics as a reference point to standardize feature representations across domains. EverAdapt not only retains statistical information from previous domains but also adapts effectively to new scenarios. Complementing CBN, we design a class-conditional domain alignment module for effective integration of target domains, and a Sample-efficient Replay strategy to reinforce memory retention. Experiments on real-world datasets demonstrate EverAdapt superiority in maintaining robust fault diagnosis in dynamic environments. Our code is available: https://github.com/mohamedr002/EverAdapt

The 7-point checklist (7PCL) is widely used in dermoscopy to identify malignant melanoma lesions needing urgent medical attention. It assigns point values to seven attributes: major attributes are worth two points each, and minor ones are worth one point each. A total score of three or higher prompts further evaluation, often including a biopsy. However, a significant limitation of current methods is the uniform weighting of attributes, which leads to imprecision and neglects their interconnections. Previous deep learning studies have treated the prediction of each attribute with the same importance as predicting melanoma, which fails to recognize the clinical significance of the attributes for melanoma. To address these limitations, we introduce a novel diagnostic method that integrates two innovative elements: a Clinical Knowledge-Based Topological Graph (CKTG) and a Gradient Diagnostic Strategy with Data-Driven Weighting Standards (GD-DDW). The CKTG integrates 7PCL attributes with diagnostic information, revealing both internal and external associations. By employing adaptive receptive domains and weighted edges, we establish connections among melanoma's relevant features. Concurrently, GD-DDW emulates dermatologists' diagnostic processes, who first observe the visual characteristics associated with melanoma and then make predictions. Our model uses two imaging modalities for the same lesion, ensuring comprehensive feature acquisition. Our method shows outstanding performance in predicting malignant melanoma and its features, achieving an average AUC value of 85%. This was validated on the EDRA dataset, the largest publicly available dataset for the 7-point checklist algorithm. Specifically, the integrated weighting system can provide clinicians with valuable data-driven benchmarks for their evaluations.

Linear causal models are important tools for modeling causal dependencies and yet in practice, only a subset of the variables can be observed. In this paper, we examine the parameter identifiability of these models by investigating whether the edge coefficients can be recovered given the causal structure and partially observed data. Our setting is more general than that of prior research - we allow all variables, including both observed and latent ones, to be flexibly related, and we consider the coefficients of all edges, whereas most existing works focus only on the edges between observed variables. Theoretically, we identify three types of indeterminacy for the parameters in partially observed linear causal models. We then provide graphical conditions that are sufficient for all parameters to be identifiable and show that some of them are provably necessary. Methodologically, we propose a novel likelihood-based parameter estimation method that addresses the variance indeterminacy of latent variables in a specific way and can asymptotically recover the underlying parameters up to trivial indeterminacy. Empirical studies on both synthetic and real-world datasets validate our identifiability theory and the effectiveness of the proposed method in the finite-sample regime.

In recent years, the clandestine nature of darknet activities has presented an escalating challenge to cybersecurity efforts, necessitating sophisticated methods for the detection and classification of network traffic associated with these covert operations. The system addresses the significant challenge of class imbalance within Darknet traffic datasets, where malicious traffic constitutes a minority, hindering effective discrimination between normal and malicious behavior. By leveraging boosting algorithms like AdaBoost and Gradient Boosting coupled with decision trees, this study proposes a robust solution for network traffic classification. Boosting algorithms ensemble learning corrects errors iteratively and assigns higher weights to minority class instances, complemented by the hierarchical structure of decision trees. The additional Feature Selection which is a preprocessing method by utilizing Information Gain metrics, Fisher's Score, and Chi-Square test selection for features is employed. Rigorous experimentation with diverse Darknet traffic datasets validates the efficacy of the proposed multistage classifier, evaluated through various performance metrics such as accuracy, precision, recall, and F1-score, offering a comprehensive solution for accurate detection and classification of Darknet activities.

Domain generalization achieves fault diagnosis on unseen modes. In process industrial systems, fault samples are limited, and only single-mode fault data can be obtained. Extracting domain-invariant fault features from single-mode data for unseen mode fault diagnosis poses challenges. Existing methods utilize a generator module to simulate samples of unseen modes. However, multi-mode samples contain complex spatiotemporal information, which brings significant difficulties to accurate sample generation. Therefore, double gradient reversal network (DGRN) is proposed. First, the model is pre-trained to acquire fault knowledge from the single seen mode. Then, pseudo-fault feature generation strategy is designed by Adaptive instance normalization, to simulate fault features of unseen mode. The dual adversarial training strategy is created to enhance the diversity of pseudo-fault features, which models unseen modes with significant distribution differences. Subsequently, domain-invariant feature extraction strategy is constructed by contrastive learning and adversarial learning. This strategy extracts common features of faults and helps multi-mode fault diagnosis. Finally, the experiments were conducted on Tennessee Eastman process and continuous stirred-tank reactor. The experiments demonstrate that DGRN achieves high classification accuracy on unseen modes while maintaining a small model size.

As language models (LMs) deliver increasing performance on a range of NLP tasks, probing classifiers have become an indispensable technique in the effort to better understand their inner workings. A typical setup involves (1) defining an auxiliary task consisting of a dataset of text annotated with labels, then (2) supervising small classifiers to predict the labels from the representations of a pretrained LM as it processed the dataset. A high probing accuracy is interpreted as evidence that the LM has learned to perform the auxiliary task as an unsupervised byproduct of its original pretraining objective. Despite the widespread usage of probes, however, the robust design and analysis of probing experiments remains a challenge. We develop a formal perspective on probing using structural causal models (SCM). Specifically, given an SCM which explains the distribution of tokens observed during training, we frame the central hypothesis as whether the LM has learned to represent the latent variables of the SCM. Empirically, we extend a recent study of LMs in the context of a synthetic grid-world navigation task, where having an exact model of the underlying causal structure allows us to draw strong inferences from the result of probing experiments. Our techniques provide robust empirical evidence for the ability of LMs to learn the latent causal concepts underlying text.