Background: Parkinson's disease (PD) is a prevalent long-term neurodegenerative disease. Though the diagnostic criteria of PD are relatively well defined, the current medical imaging diagnostic procedures are expertise-demanding, and thus call for a higher-integrated AI-based diagnostic algorithm. Methods: In this paper, we proposed an automatic, end-to-end, multi-modality diagnosis framework, including segmentation, registration, feature generation and machine learning, to process the information of the striatum for the diagnosis of PD. Multiple modalities, including T1- weighted MRI and 11C-CFT PET, were used in the proposed framework. The reliability of this framework was then validated on a dataset from the PET center of Huashan Hospital, as the dataset contains paired T1-MRI and CFT-PET images of 18 Normal (NL) subjects and 49 PD subjects. Results: We obtained an accuracy of 100% for the PD/NL classification task, besides, we conducted several comparative experiments to validate the diagnosis ability of our framework. Conclusion: Through experiment we illustrate that (1) automatic segmentation has the same classification effect as the manual segmentation, (2) the multi-modality images generates a better prediction than single modality images, and (3) volume feature is shown to be irrelevant to PD diagnosis.

In industrial systems, certain process variables that need to be monitored for detecting faults are often difficult or impossible to measure. Soft sensor techniques are widely used to estimate such difficult-to-measure process variables from easy-to-measure ones. Soft sensor modeling requires training datasets including the information of various states such as operation modes, but the fault dataset with the target variable is insufficient as the training dataset. This paper describes a semi-supervised approach to soft sensor modeling to incorporate an incomplete dataset without the target variable in the training dataset. To incorporate the incomplete dataset, we consider the properties of processes at transition points between operation modes in the system. The regression coefficients of the operation modes are estimated under constraint conditions obtained from the information on the mode transitions. In a case study, this constrained soft sensor modeling was used to predict refrigerant leaks in air-conditioning systems with heating and cooling operation modes. The results show that this modeling method is promising for soft sensors in a system with multiple operation modes.

Early fault detection using instrumented sensor data is one of the promising application areas of machine learning in industrial facilities. However, it is difficult to improve the generalization performance of the trained fault-detection model because of the complex system configuration in the target diagnostic system and insufficient fault data. It is not trivial to apply the trained model to other systems. Here we propose a fault diagnosis method for refrigerant leak detection considering the physical modeling and control mechanism of an air-conditioning system. We derive a useful scaling law related to refrigerant leak. If the control mechanism is the same, the model can be applied to other air-conditioning systems irrespective of the system configuration. Small-scale off-line fault test data obtained in a laboratory are applied to estimate the scaling exponent. We evaluate the proposed scaling law by using real-world data. Based on a statistical hypothesis test of the interaction between two groups, we show that the scaling exponents of different air-conditioning systems are equivalent. In addition, we estimated the time series of the degree of leakage of real process data based on the scaling law and confirmed that the proposed method is promising for early leak detection through comparison with assessment by experts.

The dramatic success in machine learning has led to an explosion of artificial intelligence (AI) applications and increasing expectations for autonomous systems that exhibit human-level intelligence. These expectations have, however, met with fundamental obstacles that cut across many application areas. One such obstacle is adaptability, or robustness. Machine learning researchers have noted current systems lack the ability to recognize or react to new circumstances they have not been specifically programmed or trained for. Intensive theoretical and experimental efforts toward "transfer learning," "domain adaptation," and "lifelong learning"4 are reflective of this obstacle. Another obstacle is "explainability," or that "machine learning models remain mostly black boxes"26 unable to explain the reasons behind their predictions or recommendations, thus eroding users' trust and impeding diagnosis and repair; see Hutson8 and Marcus.11 A third obstacle concerns the lack of understanding of cause-effect connections.

In this article we will discuss decision points for selecting right components for Artificial Intelligence (AI) solutions. This is also an update to Machine Learning Decision Tree (v1). Keep in mind here that AI is a broader term compared to Machine Learning.

A survey of early work exploring how AI can be used in medicine, with somewhat more technical expositions than in the complementary volume Artificial Intelligence in Medicine."Each chapter is preceded by a brief introduction that outlines our view of its contribution to the field, the reason it was selected for inclusion in this volume, an overview of its content, and a discussion of how the work evolved after the article appeared and how it relates to other chapters in the book.

This book has been adapted in large part from the author's doctoral thesis [Shortliffe, l 974b]. Portions of the work appeared previously in Computers And Biomedical Research [Shortliffe, 1973, l 975b], Mathematical Biosciences [Shortliffe, 1975a], and the Proceedings Of The Thirteenth San Diego Biomedical Symposium [Shortliffe, l 974a]. To Stanford's Medical Scientist Training Program, which is supported by the National Institutes of Health Contents

JANICE S. AIKINS Dr. Aikins received her Ph.D. in computer science from Stanford University in 1980. She is currently a research computer scientist at IBM's Palo Alto Scientific Center. She specializes in designing systems with an emphasis on the explicit representation of control knowledge in expert systems. ROBERT L. BLUM Dr. Blum received his M.D. from the University of California Medical School at San Francisco in 1973. From 1973 to 1976 he did an internship and residency in the Department of Internal Medicine at the Kaiser Foundation Hospital in Oakland, California, where he was chief resident in 1976.

A new study from China has found that an AI system can best some doctors when it comes to diagnosing common childhood diseases. The study, published in Nature Medicine yesterday (Feb. The study trained a deep-learning system on 101 million data points generated from the electronic records of 1.3 million patient visits to a medical center in Guangzhou. Researchers found that the AI system was able to meet or outperform two groups of junior physicians in accurately diagnosing a range of ailments, from asthma and pneumonia, to sinusitis and mouth-related diseases. The AI was also able to meet or exceed diagnostic performance with some groups of senior physicians, for instance, in the category of upper respiratory issues.

This is an integrative review that address the question, "What makes for a good explanation?" with reference to AI systems. Pertinent literatures are vast. Thus, this review is necessarily selective. That said, most of the key concepts and issues are expressed in this Report. The Report encapsulates the history of computer science efforts to create systems that explain and instruct (intelligent tutoring systems and expert systems). The Report expresses the explainability issues and challenges in modern AI, and presents capsule views of the leading psychological theories of explanation. Certain articles stand out by virtue of their particular relevance to XAI, and their methods, results, and key points are highlighted. It is recommended that AI/XAI researchers be encouraged to include in their research reports fuller details on their empirical or experimental methods, in the fashion of experimental psychology research reports: details on Participants, Instructions, Procedures, Tasks, Dependent Variables (operational definitions of the measures and metrics), Independent Variables (conditions), and Control Conditions.