In the present paper we describe the technology for translating algorithmic descriptions of discrete functions to SAT. The proposed methods and algorithms of translation are aimed at application to the problems of SAT-based cryptanalysis. In the theoretical part of the paper we justify the main principles of general reduction to SAT for discrete functions from a class containing the majority of functions employed in cryptography. Based on these principles we describe the Transalg software system, developed with SAT-based cryptanalysis specifics in mind. We show the results of applications of Transalg to construction of a number of attacks on various cryptographic functions. Some of the corresponding attacks are state of the art. In the paper we also present the vast experimental data, obtained using the SAT-solvers that took first places at the SAT-competitions in the recent several years.

Coordinating agents to complete a set of tasks with intercoupled temporal and resource constraints is computationally challenging, yet human domain experts can solve these difficult scheduling problems using paradigms learned through years of apprenticeship. A process for manually codifying this domain knowledge within a computational framework is necessary to scale beyond the ``single-expert, single-trainee" apprenticeship model. However, human domain experts often have difficulty describing their decision-making processes, causing the codification of this knowledge to become laborious. We propose a new approach for capturing domain-expert heuristics through a pairwise ranking formulation. Our approach is model-free and does not require enumerating or iterating through a large state space. We empirically demonstrate that this approach accurately learns multifaceted heuristics on a synthetic data set incorporating job-shop scheduling and vehicle routing problems, as well as on two real-world data sets consisting of demonstrations of experts solving a weapon-to-target assignment problem and a hospital resource allocation problem. We also demonstrate that policies learned from human scheduling demonstration via apprenticeship learning can substantially improve the efficiency of a branch-and-bound search for an optimal schedule. We employ this human-machine collaborative optimization technique on a variant of the weapon-to-target assignment problem. We demonstrate that this technique generates solutions substantially superior to those produced by human domain experts at a rate up to 9.5 times faster than an optimization approach and can be applied to optimally solve problems twice as complex as those solved by a human demonstrator.

Sudoku is a well-known logic-based puzzle game that was first published in 1979 under the name of "Number Place". It was popularised in Japan in 1984 by the puzzle company Nikoli, and later named "Sudoku", which roughly translates to "single digits". The puzzle gained attention in the West in 2004, after The Times published its first Sudoku grid (at the instigation of Hong Kong-based judge Wayne Gould, who first encountered the puzzle in 1997, and developed a computer program to automatically generate instances). Sudoku is now a global phenomenon, and many newspapers now carry it alongside their existing crosswords (see [4] for a general history of the puzzle). The simplest variant of Sudoku uses a 9 9 grid of cells divided into nine 3 3 subgrids (Figure 1 (left)). The aim of the puzzle is to fill the grid with digits such that each row, each column, and each 3 3 subgrid contains all of the digits 1-9 (Figure 1 (right)). An instance of Sudoku provides, at the outset, a partially-completed grid, but the difficulty of any grid derives more from the range of techniques required to solve it than the number of cell values that are provided for the player. Sudoku is an NPcomplete problem [12], as first shown in [35] (via a reduction from the Latin Square Completion problem [2]).

Using AI approaches to automatically design mechanisms has been a central research mission at the interface of AI and economics [Conitzer and Sandholm, 2002]. Previous approaches that a empt to design revenue optimal auctions for the multi-dimensional settings fall short in at least one of the three aspects: 1) representation --- search in a space that probably does not even contain the optimal mechanism; 2) exactness --- finding a mechanism that is either not truthful or far from optimal; 3) domain dependence --- need a different design for different environment settings. To resolve the three difficulties, in this paper, we put forward a uni ed neural network based framework that automatically learns to design revenue optimal mechanisms. Our framework consists of a mechanism network that takes an input distribution for training and outputs a mechanism, as well as a buyer network that takes a mechanism as input and output an action. Such a separation in design mitigates the difficulty to impose incentive compatibility constraints on the mechanism, by making it a rational choice of the buyer. As a result, our framework easily overcomes the previously mentioned difficulty in incorporating IC constraints and always returns exactly incentive compatible mechanisms. We then applied our framework to a number of multi-item revenue optimal design settings, for a few of which the theoretically optimal mechanisms are unknown. We then go on to theoretically prove that the mechanisms found by our framework are indeed optimal.

Outpatient clinics often run behind schedule due to patients who arrive late or appointments that run longer than expected. We sought to develop a generalizable method that would allow healthcare providers to diagnose problems in workflow that disrupt the schedule on any given provider clinic day. We use a constraint optimization problem to identify the least number of appointment modifications that make the rest of the schedule run on-time. We apply this method to an outpatient clinic at Vanderbilt. For patient seen in this clinic between March 27, 2017 and April 21, 2017, long cycle times tended to affect the overall schedule more than late patients. Results from this workflow diagnosis method could be used to inform interventions to help clinics run smoothly, thus decreasing patient wait times and increasing provider utilization.

Journal of Parallel and Distributed Computing 104, 19-35.

We propose a technique for declaratively specifying strategies for semi-supervised learning (SSL). The proposed method can be used to specify ensembles of semi-supervised learning, as well as agreement constraints and entropic regularization constraints between these learners, and can be used to model both well-known heuristics such as co-training and novel domain-specific heuristics. In addition to representing individual SSL heuristics, we show that multiple heuristics can also be automatically combined using Bayesian optimization methods. We show consistent improvements on a suite of well-studied SSL benchmarks, including a new state-of-the-art result on a difficult relation extraction task.

Markus Heinonen 1, 2, Maria Osmala 1, Henrik Mannerstr om 1, Janne Wallenius 3 Samuel Kaski 1, 2, Juho Rousu 1, 2 and Harri L ahdesm aki 1 1 Department of Computer Science, Aalto University, Espoo, 02150, Finland 2 Helsinki Institute for Information Technology, Finland 3 Institute for Molecular Medicine Finland, Helsinki, Finland Abstract Motivation: Metabolic flux balance analyses are a standard tool in analysing metabolic reaction rates compatible with measurements, steady-state and the metabolic reaction network stoichiometry. Flux analysis methods commonly place unrealistic assumptions on fluxes due to the convenience of formulating the problem as a linear programming model, and most methods ignore the notable uncertainty in flux estimates. Results: We introduce a novel paradigm of Bayesian metabolic flux analysis that models the reactions of the whole genome-scale cellular system in probabilistic terms, and can infer the full flux vector distribution of genome-scale metabolic systems based on exchange and intracellular (e.g. The Bayesian model couples all fluxes jointly together in a simple truncated multivariate posterior distribution, which reveals informative flux couplings. Our model is a plugin replacement to conventional metabolic balance methods, such as flux balance analysis (FBA). Our experiments indicate that we can characterise the genome-scale flux covariances, reveal flux couplings, and determine more intracellular unobserved fluxes in C. acetobutylicum from 13C data than flux variability analysis. Contact: markus.o.heinonen@aalto.fi 1 Introduction Metabolic modelling considers networks of up to thousands of chemical reactions that transform metabolite molecules within cellular organisms (Palsson, 2015). The key problem of metabolism is estimation of the reaction rates, or fluxes, of the system of the highly interdependent intracellular fluxes from measurements of few exchange fluxes that transfer nutrients or products between the external medium and the cell. The dominant approach to flux estimation is the celebrated Flux Balance Analysis (FBA) framework that finds reaction rates that maximise prespecified cellular growth function (Feist and Palsson, 2010), while assuming the cell is in a steady-state, where concentrations of intracellular metabolites do not change (Almaas et al., 2004). The FBA problem can be casted as a convenient and computationally efficient linear programming problem of solving a system of linear steady-state constraints while maximising a linear growth target (Orth et al., 2010), and where flux measurements can be encoded as constraints to the fluxes (Carreira et al., 2014).

The subgraph isomorphism problem involves deciding whether a copy of a pattern graph occurs inside a larger target graph. The non-induced version allows extra edges in the target, whilst the induced version does not. Although both variants are NP-complete, algorithms inspired by constraint programming can operate comfortably on many real-world problem instances with thousands of vertices. However, they cannot handle arbitrary instances of this size. We show how to generate "really hard" random instances for subgraph isomorphism problems, which are computationally challenging with a couple of hundred vertices in the target, and only twenty pattern vertices. For the non-induced version of the problem, these instances lie on a satisfiable / unsatisfiable phase transition, whose location we can predict; for the induced variant, much richer behaviour is observed, and constrainedness gives a better measure of difficulty than does proximity to a phase transition. These results have practical consequences: we explain why the widely researched "filter / verify" indexing technique used in graph databases is founded upon a misunderstanding of the empirical hardness of NP-complete problems, and cannot be beneficial when paired with any reasonable subgraph isomorphism algorithm.

The field of multi-agent system (MAS) is an active area of research within artificial intelligence, with an increasingly important impact in industrial and other real-world applications. In a MAS, autonomous agents interact to pursue personal interests and/or to achieve common objectives. Distributed Constraint Optimization Problems (DCOPs) have emerged as a prominent agent model to govern the agents' autonomous behavior, where both algorithms and communication models are driven by the structure of the specific problem. During the last decade, several extensions to the DCOP model have been proposed to enable support of MAS in complex, real-time, and uncertain environments. This survey provides an overview of the DCOP model, offering a classification of its multiple extensions and addressing both resolution methods and applications that find a natural mapping within each class of DCOPs. The proposed classification suggests several future perspectives for DCOP extensions and identifies challenges in the design of efficient resolution algorithms, possibly through the adaptation of strategies from different areas.