The discovery of novel small molecule drugs remains a critical scientific challenge with far-reaching implications for treating diseases and advancing human health. Traditional drug development--especially for small molecule therapeutics--is a highly complex, resource-intensive, and time-consuming process that requires multidisciplinary collaboration. Recent breakthroughs in artificial intelligence (AI), particularly the rise of large language models (LLMs), present a transformative opportunity to streamline and accelerate this process. In this paper, we introduce PharmAgents, a virtual pharmaceutical ecosystem driven by LLM-based multi-agent collaboration. PharmAgents simulates the full drug discovery workflow--from target discovery to preclinical evaluation--by integrating explainable, LLM-driven agents equipped with specialized machine learning models and computational tools. Through structured knowledge exchange and automated optimization, PharmAgents identifies potential therapeutic targets, discovers promising lead compounds, enhances binding affinity and key molecular properties, and performs in silico analyses of toxicity and synthetic feasibility. Additionally, the system supports interpretability, agent interaction, and self-evolvement, enabling it to refine future drug designs based on prior experience. By showcasing the potential of LLM-powered multi-agent systems in drug discovery, this work establishes a new paradigm for autonomous, explainable, and scalable pharmaceutical research, with future extensions toward comprehensive drug lifecycle management.

Despite advances in embodied AI, agent reasoning systems still struggle to capture the fundamental conceptual structures that humans naturally use to understand and interact with their environment. To address this, we propose a novel framework that bridges embodied cognition theory and agent systems by leveraging a formal characterization of image schemas, which are defined as recurring patterns of sensorimotor experience that structure human cognition. By customizing LLMs to translate natural language descriptions into formal representations based on these sensorimotor patterns, we will be able to create a neurosymbolic system that grounds the agent's understanding in fundamental conceptual structures. We argue that such an approach enhances both efficiency and interpretability while enabling more intuitive human-agent interactions through shared embodied understanding.

-- We show how graphons can be used to model and analyze open multi-agent systems, which are multi-agent systems subject to arrivals and departures, in the specific case of linear consensus. First, we analyze the case of replacements, where under the assumption of a deterministic interval between two replacements, we derive an upper bound for the disagreement in expectation. Then, we study the case of arrivals and departures, where we define a process for the evolution of the number of agents that guarantees a minimum and a maximum number of agents. Next, we derive an upper bound for the disagreement in expectation, and we establish a link with the spectrum of the expected graph used to generate the graph topologies. Finally, for stochastic block model (SBM) graphons, we prove that the computation of the spectrum of the expected graph can be performed based on a matrix whose dimension depends only on the graphon and it is independent of the number of agents. Open multi-agent systems are a framework used to analyze networks subject to arrivals, departures or replacements of agents at a rate similar to the scale time of the process [1], [2]. This type of systems are essentially characterized by the agent internal dynamics, the evolution of the network and the arrivals and departures [3]. This is usually done by considering trivial dynamics like complete graphs [4]-[6], bounds on the algebraic connectivity or diameter [7], [8] or just connectivity at all time instants [9].

Large language model-based agents are increasingly used in recommender systems (Agent4RSs) to achieve personalized behavior modeling. Specifically, Agent4RSs introduces memory mechanisms that enable the agents to autonomously learn and self-evolve from real-world interactions. However, to the best of our knowledge, how robust Agent4RSs are remains unexplored. As such, in this paper, we propose the first work to attack Agent4RSs by perturbing agents' memories, not only to uncover their limitations but also to enhance their security and robustness, ensuring the development of safer and more reliable AI agents. Given the security and privacy concerns, it is more practical to launch attacks under a black-box setting, where the accurate knowledge of the victim models cannot be easily obtained. Moreover, the practical attacks are often stealthy to maximize the impact. To this end, we propose a novel practical attack framework named DrunkAgent. DrunkAgent consists of a generation module, a strategy module, and a surrogate module. The generation module aims to produce effective and coherent adversarial textual triggers, which can be used to achieve attack objectives such as promoting the target items. The strategy module is designed to `get the target agents drunk' so that their memories cannot be effectively updated during the interaction process. As such, the triggers can play the best role. Both of the modules are optimized on the surrogate module to improve the transferability and imperceptibility of the attacks. By identifying and analyzing the vulnerabilities, our work provides critical insights that pave the way for building safer and more resilient Agent4RSs. Extensive experiments across various real-world datasets demonstrate the effectiveness of DrunkAgent.

Balancing games, especially those with asymmetric multiplayer content, requires significant manual effort and extensive human playtesting during development. For this reason, this work focuses on generating balanced levels tailored to asymmetric player archetypes, where the disparity in abilities is balanced entirely through the level design. For instance, while one archetype may have an advantage over another, both should have an equal chance of winning. We therefore conceptualize game balancing as a procedural content generation problem and build on and extend a recently introduced method that uses reinforcement learning to balance tile-based game levels. We evaluate the method on four different player archetypes and demonstrate its ability to balance a larger proportion of levels compared to two baseline approaches. Furthermore, our results indicate that as the disparity between player archetypes increases, the required number of training steps grows, while the model's accuracy in achieving balance decreases.

Personalized multiple clustering aims to generate diverse partitions of a dataset based on different user-specific aspects, rather than a single clustering. It has recently drawn research interest for accommodating varying user preferences. Recent approaches primarily use CLIP embeddings with proxy learning to extract representations biased toward user clustering preferences. However, CLIP primarily focuses on coarse image-text alignment, lacking a deep contextual understanding of user interests. To overcome these limitations, we propose an agent-centric personalized clustering framework that leverages multi-modal large language models (MLLMs) as agents to comprehensively traverse a relational graph to search for clusters based on user interests. Due to the advanced reasoning mechanism of MLLMs, the obtained clusters align more closely with user-defined criteria than those obtained from CLIP-based representations. To reduce computational overhead, we shorten the agents' traversal path by constructing a relational graph using user-interest-biased embeddings extracted by MLLMs. A large number of weakly connected edges can be filtered out based on embedding similarity, facilitating an efficient traversal search for agents. Experimental results show that the proposed method achieves NMI scores of 0.9667 and 0.9481 on the Card Order and Card Suits benchmarks, respectively, largely improving the SOTA model by over 140%.

What drives exploration? Understanding intrinsic motivation is a long-standing challenge in both cognitive science and artificial intelligence; numerous objectives have been proposed and used to train agents, yet there remains a gap between human and agent exploration. We directly compare adults, children, and AI agents in a complex open-ended environment, Crafter, and study how common intrinsic objectives: Entropy, Information Gain, and Empowerment, relate to their behavior. We find that only Entropy and Empowerment are consistently positively correlated with human exploration progress, indicating that these objectives may better inform intrinsic reward design for agents. Furthermore, across agents and humans we observe that Entropy initially increases rapidly, then plateaus, while Empowerment increases continuously, suggesting that state diversity may provide more signal in early exploration, while advanced exploration should prioritize control. Finally, we find preliminary evidence that private speech utterances, and particularly goal verbalizations, may aid exploration in children.

Reinforcement learning (RL), with its ability to explore and optimize policies in complex, dynamic decision-making tasks, has emerged as a promising approach to addressing motion planning (MoP) challenges in autonomous driving (AD). Despite rapid advancements in RL and AD, a systematic description and interpretation of the RL design process tailored to diverse driving tasks remains underdeveloped. This survey provides a comprehensive review of RL-based MoP for AD, focusing on lessons from task-specific perspectives. We first outline the fundamentals of RL methodologies, and then survey their applications in MoP, analyzing scenario-specific features and task requirements to shed light on their influence on RL design choices. Building on this analysis, we summarize key design experiences, extract insights from various driving task applications, and provide guidance for future implementations. Additionally, we examine the frontier challenges in RL-based MoP, review recent efforts to addresse these challenges, and propose strategies for overcoming unresolved issues.

GUI agents, powered by large foundation models, can interact with digital interfaces, enabling various applications in web automation, mobile navigation, and software testing. However, their increasing autonomy has raised critical concerns about their security, privacy, and safety. This survey examines the trustworthiness of GUI agents in five critical dimensions: security vulnerabilities, reliability in dynamic environments, transparency and explainability, ethical considerations, and evaluation methodologies. We also identify major challenges such as vulnerability to adversarial attacks, cascading failure modes in sequential decision-making, and a lack of realistic evaluation benchmarks. These issues not only hinder real-world deployment but also call for comprehensive mitigation strategies beyond task success. As GUI agents become more widespread, establishing robust safety standards and responsible development practices is essential. This survey provides a foundation for advancing trustworthy GUI agents through systematic understanding and future research.

Misinformation spans various domains, but detection methods trained on specific domains often perform poorly when applied to others. With the rapid development of Large Language Models (LLMs), researchers have begun to utilize LLMs for cross-domain misinformation detection. However, existing LLM-based methods often fail to adequately analyze news in the target domain, limiting their detection capabilities. More importantly, these methods typically rely on manually designed decision rules, which are limited by domain knowledge and expert experience, thus limiting the generalizability of decision rules to different domains. To address these issues, we propose a MultiAgent Framework for cross-domain misinformation detection with Automated Decision Rule Optimization (MARO). Under this framework, we first employs multiple expert agents to analyze target-domain news. Subsequently, we introduce a question-reflection mechanism that guides expert agents to facilitate higherquality analysis. Furthermore, we propose a decision rule optimization approach based on carefully-designed cross-domain validation tasks to iteratively enhance the effectiveness of decision rules in different domains. Experimental results and in-depth analysis on commonlyused datasets demonstrate that MARO achieves significant improvements over existing methods.