Agents
Speak to a Protein: An Interactive Multimodal Co-Scientist for Protein Analysis
Navarro, Carles, Torrens, Mariona, Thölke, Philipp, Doerr, Stefan, De Fabritiis, Gianni
Building a working mental model of a protein typically requires weeks of reading, cross-referencing crystal and predicted structures, and inspecting ligand complexes, an effort that is slow, unevenly accessible, and often requires specialized computational skills. We introduce \emph{Speak to a Protein}, a new capability that turns protein analysis into an interactive, multimodal dialogue with an expert co-scientist. The AI system retrieves and synthesizes relevant literature, structures, and ligand data; grounds answers in a live 3D scene; and can highlight, annotate, manipulate and see the visualization. It also generates and runs code when needed, explaining results in both text and graphics. We demonstrate these capabilities on relevant proteins, posing questions about binding pockets, conformational changes, or structure-activity relationships to test ideas in real-time. \emph{Speak to a Protein} reduces the time from question to evidence, lowers the barrier to advanced structural analysis, and enables hypothesis generation by tightly coupling language, code, and 3D structures. \emph{Speak to a Protein} is freely accessible at https://open.playmolecule.org.
ATL*AS: An Automata-Theoretic Approach and Tool for the Verification of Strategic Abilities in Multi-Agent Systems
Garcia-Alcalde, Sofia Garcia de Blas, Belardinelli, Francesco
We present two novel symbolic algorithms for model checking the Alternating-time Temporal Logic ATL*, over both the infinite-trace and the finite-trace semantics. In particular, for infinite traces we design a novel symbolic reduction to parity games. We implement both methods in the ATL*AS model checker and evaluate it using synthetic benchmarks as well as a cybersecurity scenario. Our results demonstrate that the symbolic approach significantly outperforms the explicit-state representation and we find that our parity-game-based algorithm offers a more scalable and efficient solution for infinite-trace verification, outperforming previously available tools. Our results also confirm that finite-trace model checking yields substantial performance benefits over infinite-trace verification. As such, we provide a comprehensive toolset for verifying multiagent systems against specifications in ATL*.
Stop Reducing Responsibility in LLM-Powered Multi-Agent Systems to Local Alignment
Hu, Jinwei, Dong, Yi, Ao, Shuang, Li, Zhuoyun, Wang, Boxuan, Singh, Lokesh, Cheng, Guangliang, Ramchurn, Sarvapali D., Huang, Xiaowei
LLM-powered Multi-Agent Systems (LLM-MAS) unlock new potentials in distributed reasoning, collaboration, and task generalization but also introduce additional risks due to unguaranteed agreement, cascading uncertainty, and adversarial vulnerabilities. We argue that ensuring responsible behavior in such systems requires a paradigm shift: from local, superficial agent-level alignment to global, systemic agreement. We conceptualize responsibility not as a static constraint but as a lifecycle-wide property encompassing agreement, uncertainty, and security, each requiring the complementary integration of subjective human-centered values and objective verifiability. Furthermore, a dual-perspective governance framework that combines interdisciplinary design with human-AI collaborative oversight is essential for tracing and ensuring responsibility throughout the lifecycle of LLM-MAS. Our position views LLM-MAS not as loose collections of agents, but as unified, dynamic socio-technical systems that demand principled mechanisms to support each dimension of responsibility and enable ethically aligned, verifiably coherent, and resilient behavior for sustained, system-wide agreement.
Static Sandboxes Are Inadequate: Modeling Societal Complexity Requires Open-Ended Co-Evolution in LLM-Based Multi-Agent Simulations
Chen, Jinkun, Badshah, Sher, Yu, Xuemin, Han, Sijia
What if artificial agents could not just communicate, but also evolve, adapt, and reshape their worlds in ways we cannot fully predict? With llm now powering multi-agent systems and social simulations, we are witnessing new possibilities for modeling open-ended, ever-changing environments. Yet, most current simulations remain constrained within static sandboxes, characterized by predefined tasks, limited dynamics, and rigid evaluation criteria. These limitations prevent them from capturing the complexity of real-world societies. In this paper, we argue that static, task-specific benchmarks are fundamentally inadequate and must be rethought. We critically review emerging architectures that blend llm with multi-agent dynamics, highlight key hurdles such as balancing stability and diversity, evaluating unexpected behaviors, and scaling to greater complexity, and introduce a fresh taxonomy for this rapidly evolving field. Finally, we present a research roadmap centered on open-endedness, continuous co-evolution, and the development of resilient, socially aligned AI ecosystems. We call on the community to move beyond static paradigms and help shape the next generation of adaptive, socially-aware multi-agent simulations.
Hierarchical Planning for Long-Horizon Multi-Target Tracking Under Target Motion Uncertainty
Yuan, Junbin, Moon, Brady, Cao, Muqing, Scherer, Sebastian
Achieving persistent tracking of multiple dynamic targets over a large spatial area poses significant challenges for a single-robot system with constrained sensing capabilities. As the robot moves to track different targets, the ones outside the field of view accumulate uncertainty, making them progressively harder to track. An effective path planning algorithm must manage uncertainty over a long horizon and account for the risk of permanently losing track of targets that remain unseen for too long. However, most existing approaches rely on short planning horizons and assume small, bounded environments, resulting in poor tracking performance and target loss in large-scale scenarios. In this paper, we present a hierarchical planner for tracking multiple moving targets with an aerial vehicle. To address the challenge of tracking non-static targets, our method incorporates motion models and uncertainty propagation during path execution, allowing for more informed decision-making. We decompose the multi-target tracking task into sub-tasks of single target search and detection, and our proposed pipeline consists a novel low-level coverage planner that enables searching for a target in an evolving belief area, and an estimation method to assess the likelihood of success for each sub-task, making it possible to convert the active target tracking task to a Markov decision process (MDP) that we solve with a tree-based algorithm to determine the sequence of sub-tasks. We validate our approach in simulation, demonstrating its effectiveness compared to existing planners for active target tracking tasks, and our proposed planner outperforms existing approaches, achieving a reduction of 11-70% in final uncertainty across different environments.
Seeing through Uncertainty: Robust Task-Oriented Optimization in Visual Navigation
Pan, Yiyuan, Xu, Yunzhe, Liu, Zhe, Wang, Hesheng
Visual navigation is a fundamental problem in embodied AI, yet practical deployments demand long-horizon planning capabilities to address multi-objective tasks. A major bottleneck is data scarcity: policies learned from limited data often overfit and fail to generalize OOD. Existing neural network-based agents typically increase architectural complexity that paradoxically become counterproductive in the small-sample regime. This paper introduce NeuRO, a integrated learning-to-optimize framework that tightly couples perception networks with downstream task-level robust optimization. Specifically, NeuRO addresses core difficulties in this integration: (i) it transforms noisy visual predictions under data scarcity into convex uncertainty sets using Partially Input Convex Neural Networks (PICNNs) with conformal calibration, which directly parameterize the optimization constraints; and (ii) it reformulates planning under partial observability as a robust optimization problem, enabling uncertainty-aware policies that transfer across environments. Extensive experiments on both unordered and sequential multi-object navigation tasks demonstrate that NeuRO establishes SoTA performance, particularly in generalization to unseen environments. Our work thus presents a significant advancement for developing robust, generalizable autonomous agents.
Tree of Agents: Improving Long-Context Capabilities of Large Language Models through Multi-Perspective Reasoning
Yu, Song, Xu, Xiaofei, Deng, Ke, Li, Li, Tian, Lin
Large language models (LLMs) face persistent challenges when handling long-context tasks, most notably the lost in the middle issue, where information located in the middle of a long input tends to be underutilized. Some existing methods that reduce input have the risk of discarding key information, while others that extend context windows often lead to attention dispersion. To address these limitations, we propose Tree of Agents (TOA), a multi-agent reasoning framework that segments the input into chunks processed by independent agents. Each agent generates its local cognition, then agents dynamically exchange information for collaborative reasoning along tree-structured paths. TOA enables agents to probe different reasoning orders for multi-perspective understanding, effectively mitigating position bias and reducing hallucinations. To improve processing efficiency, we incorporate prefix-hash caching and adaptive pruning strategies, achieving significant performance improvements with comparable API overhead. Experiments show that TOA, powered by compact LLaMA3.1-8B, significantly outperforms multiple baselines and demonstrates comparable performance to the latest and much larger commercial models, such as Gemini1.5-pro, on various long-context tasks. Code is available at https://github.com/Aireduce952/Tree-of-Agents.
PowerChain: A Verifiable Agentic AI System for Automating Distribution Grid Analyses
Badmus, Emmanuel O., Sang, Peng, Stamoulis, Dimitrios, Pandey, Amritanshu
Rapid electrification and decarbonization are increasing the complexity of distribution grid (DG) operation and planning, necessitating advanced computational analyses to ensure reliability and resilience. These analyses depend on disparate workflows comprising complex models, function calls, and data pipelines that require substantial expert knowledge and remain difficult to automate. Workforce and budget constraints further limit utilities' ability to apply such analyses at scale. To address this gap, we build an agentic system PowerChain, which is capable of autonomously performing complex grid analyses. Existing agentic AI systems are typically developed in a bottom-up manner with customized context for predefined analysis tasks; therefore, they do not generalize to tasks that the agent has never seen. In comparison, to generalize to unseen DG analysis tasks, PowerChain dynamically generates structured context by leveraging supervisory signals from self-contained power systems tools (e.g., GridLAB-D) and an optimized set of expert-annotated and verified reasoning trajectories. For complex DG tasks defined in natural language, empirical results on real utility data demonstrate that PowerChain achieves up to a 144/% improvement in performance over baselines.
An Automated Multi-modal Evaluation Framework for Mobile Intelligent Assistants Based on Large Language Models and Multi-Agent Collaboration
Wang, Meiping, Zhong, Jian, Han, Rongduo, Kang, Liming, Shi, Zhengkun, Liang, Xiao, Lin, Xing, Gao, Nan, Zhang, Haining
With the rapid development of mobile intelligent assistant technologies, multi-modal AI assistants have become essential interfaces for daily user interactions. However, current evaluation methods face challenges including high manual costs, inconsistent standards, and subjective bias. This paper proposes an automated multi-modal evaluation framework based on large language models and multi-agent collaboration. The framework employs a three-tier agent architecture consisting of interaction evaluation agents, semantic verification agents, and experience decision agents. Through supervised fine-tuning on the Qwen3-8B model, we achieve a significant evaluation matching accuracy with human experts. Experimental results on eight major intelligent agents demonstrate the framework's effectiveness in predicting users' satisfaction and identifying generation defects.
FlySearch: Exploring how vision-language models explore
Pardyl, Adam, Matuszek, Dominik, Przebieracz, Mateusz, Cygan, Marek, Zieliński, Bartosz, Wołczyk, Maciej
The real world is messy and unstructured. Uncovering critical information often requires active, goal-driven exploration. It remains to be seen whether Vision-Language Models (VLMs), which recently emerged as a popular zero-shot tool in many difficult tasks, can operate effectively in such conditions. In this paper, we answer this question by introducing FlySearch, a 3D, outdoor, photorealistic environment for searching and navigating to objects in complex scenes. We define three sets of scenarios with varying difficulty and observe that state-of-the-art VLMs cannot reliably solve even the simplest exploration tasks, with the gap to human performance increasing as the tasks get harder. We identify a set of central causes, ranging from vision hallucination, through context misunderstanding, to task planning failures, and we show that some of them can be addressed by finetuning. We publicly release the benchmark, scenarios, and the underlying codebase.