Clinical trials play an important role in cancer care and research, yet participation rates remain low. We developed MSK-MATCH (Memorial Sloan Kettering Multi-Agent Trial Coordination Hub), an AI system for automated eligibility screening from clinical text. MSK-MATCH integrates a large language model with a curated oncology trial knowledge base and retrieval-augmented architecture providing explanations for all AI predictions grounded in source text. In a retrospective dataset of 88,518 clinical documents from 731 patients across six breast cancer trials, MSK-MATCH automatically resolved 61.9% of cases and triaged 38.1% for human review. This AI-assisted workflow achieved 98.6% accuracy, 98.4% sensitivity, and 98.7% specificity for patient-level eligibility classification, matching or exceeding performance of the human-only and AI-only comparisons. For the triaged cases requiring manual review, prepopulating eligibility screens with AI-generated explanations reduced screening time from 20 minutes to 43 seconds at an average cost of $0.96 per patient-trial pair.

Agentic language models compose multi step reasoning chains, yet intermediate steps can be corrupted by inconsistent context, retrieval errors, or adversarial inputs, which makes post hoc evaluation too late because errors propagate before detection. We introduce a diagnostic that requires no additional training and uses only the forward pass to emit a binary accept or reject signal during agent execution. The method analyzes token graphs induced by attention and computes two spectral statistics in early layers, namely the high frequency energy ratio and spectral entropy. We formalize these signals, establish invariances, and provide finite sample estimators with uncertainty quantification. Under a two regime mixture assumption with a monotone likelihood ratio property, we show that a single threshold on the high frequency energy ratio is optimal in the Bayes sense for detecting context inconsistency. Empirically, the high frequency energy ratio exhibits robust bimodality during context verification across multiple model families, which enables gating decisions with overhead below one millisecond on our hardware and configurations. We demonstrate integration into retrieval augmented agent pipelines and discuss deployment as an inline safety monitor. The approach detects contamination while the model is still processing the text, before errors commit to the reasoning chain.

Inverse Game Theory (IGT) methods based on the entropy-regularized Quantal Response Equilibrium (QRE) offer a tractable approach for competitive settings, but critically assume the agents' rationality parameter (temperature $τ$) is known a priori. When $τ$ is unknown, a fundamental scale ambiguity emerges that couples $τ$ with the reward parameters ($θ$), making them statistically unidentifiable. We introduce Blind-IGT, the first statistical framework to jointly recover both $θ$ and $τ$ from observed behavior. We analyze this bilinear inverse problem and establish necessary and sufficient conditions for unique identification by introducing a normalization constraint that resolves the scale ambiguity. We propose an efficient Normalized Least Squares (NLS) estimator and prove it achieves the optimal $\mathcal{O}(N^{-1/2})$ convergence rate for joint parameter recovery. When strong identifiability conditions fail, we provide partial identification guarantees through confidence set construction. We extend our framework to Markov games and demonstrate optimal convergence rates with strong empirical performance even when transition dynamics are unknown.

Hurricanes are America's most destructive natural hazards, causing more deaths and property damage than any other type of disaster. Since 1980, these powerful tropical storms have done more than US$1.5 trillion in damage and killed more than 7,000 people. The No. 1 cause of the damages and deaths from hurricanes is storm surge . Storm surge is the rise in the ocean's water level, caused by a combination of powerful winds pushing water toward the coastline and reduced air pressure within the hurricane compared to the pressure outside of it. In addition to these factors, waves breaking close to the coast causes sea level to increase near the coastline, a phenomenon we call wave setup, which can be an important component of storm surge.

Large Language Models (LLMs) have demonstrated strong capabilities as autonomous agents through tool use, planning, and decision-making abilities, leading to their widespread adoption across diverse tasks. As task complexity grows, multi-agent LLM systems are increasingly used to solve problems collaboratively. However, safety and security of these systems remains largely under-explored. Existing benchmarks and datasets predominantly focus on single-agent settings, failing to capture the unique vulnerabilities of multi-agent dynamics and co-ordination. To address this gap, we introduce $\textbf{T}$hreats and $\textbf{A}$ttacks in $\textbf{M}$ulti-$\textbf{A}$gent $\textbf{S}$ystems ($\textbf{TAMAS}$), a benchmark designed to evaluate the robustness and safety of multi-agent LLM systems. TAMAS includes five distinct scenarios comprising 300 adversarial instances across six attack types and 211 tools, along with 100 harmless tasks. We assess system performance across ten backbone LLMs and three agent interaction configurations from Autogen and CrewAI frameworks, highlighting critical challenges and failure modes in current multi-agent deployments. Furthermore, we introduce Effective Robustness Score (ERS) to assess the tradeoff between safety and task effectiveness of these frameworks. Our findings show that multi-agent systems are highly vulnerable to adversarial attacks, underscoring the urgent need for stronger defenses. TAMAS provides a foundation for systematically studying and improving the safety of multi-agent LLM systems.

As information grows exponentially, enterprises face increasing pressure to transform unstructured data into coherent, actionable insights. While autonomous agents show promise, they often struggle with domain-specific nuances, intent alignment, and enterprise integration. We present Enterprise Deep Research (EDR), a multi-agent system that integrates (1) a Master Planning Agent for adaptive query decomposition, (2) four specialized search agents (General, Academic, GitHub, LinkedIn), (3) an extensible MCP-based tool ecosystem supporting NL2SQL, file analysis, and enterprise workflows, (4) a Visualization Agent for data-driven insights, and (5) a reflection mechanism that detects knowledge gaps and updates research direction with optional human-in-the-loop steering guidance. These components enable automated report generation, real-time streaming, and seamless enterprise deployment, as validated on internal datasets. On open-ended benchmarks including DeepResearch Bench and DeepConsult, EDR outperforms state-of-the-art agentic systems without any human steering. We release the EDR framework and benchmark trajectories to advance research on multi-agent reasoning applications. Code at https://github.com/SalesforceAIResearch/enterprise-deep-research and Dataset at https://huggingface.co/datasets/Salesforce/EDR-200

In this report, we describe the technical details of our submission to the IROS 2025 RoboSense Challenge Social Navigation Track. This track focuses on developing RGBD-based perception and navigation systems that enable autonomous agents to navigate safely, efficiently, and socially compliantly in dynamic human-populated indoor environments. The challenge requires agents to operate from an egocentric perspective using only onboard sensors including RGB-D observations and odometry, without access to global maps or privileged information, while maintaining social norm compliance such as safe distances and collision avoidance. Building upon the Falcon model, we introduce a Proactive Risk Perception Module to enhance social navigation performance. Our approach augments Falcon with collision risk understanding that learns to predict distance-based collision risk scores for surrounding humans, which enables the agent to develop more robust spatial awareness and proactive collision avoidance behaviors. The evaluation on the Social-HM3D benchmark demonstrates that our method improves the agent's ability to maintain personal space compliance while navigating toward goals in crowded indoor scenes with dynamic human agents, achieving 2nd place among 16 participating teams in the challenge.

This study raises and addresses the problem of time-delayed feedback in learning in games. Because learning in games assumes that multiple agents independently learn their strategies, a discrepancy in optimization often emerges among the agents. To overcome this discrepancy, the prediction of the future reward is incorporated into algorithms, typically known as Optimistic Follow-the-Regularized-Leader (OFTRL). However, the time delay in observing the past rewards hinders the prediction. Indeed, this study firstly proves that even a single-step delay worsens the performance of OFTRL from the aspects of social regret and convergence. This study proposes the weighted OFTRL (WOFTRL), where the prediction vector of the next reward in OFTRL is weighted $n$ times. We further capture an intuition that the optimistic weight cancels out this time delay. We prove that when the optimistic weight exceeds the time delay, our WOFTRL recovers the good performances that social regret is constant in general-sum normal-form games, and the strategies last-iterate converge to the Nash equilibrium in poly-matrix zero-sum games. The theoretical results are supported and strengthened by our experiments.

Agentic workflows, where multiple AI agents collaborate to accomplish complex tasks like reasoning or planning, play a substantial role in many cutting-edge commercial applications, and continue to fascinate researchers across fields for their potential to accomplish expensive, complex tasks that, until recently, only humans have been trusted to do. These workflows depend critically on the prompts used to provide the roles models play in such workflows. Poorly designed prompts that fail even slightly to guide individual agents can lead to sub-optimal performance that may snowball within a system of agents, limiting their reliability and scalability. To address this important problem of inference-time prompt optimization, we introduce ProRefine, an innovative inference-time optimization method that uses an agentic loop of LLMs to generate and apply textual feedback. ProRefine dynamically refines prompts for multi-step reasoning tasks without additional training or ground truth labels. Evaluated on five benchmark mathematical reasoning datasets, ProRefine significantly surpasses zero-shot Chain-of-Thought baselines by 3 to 37 percentage points. This approach not only boosts accuracy but also allows smaller models to approach the performance of their larger counterparts. This highlights its potential for building more cost-effective and powerful hybrid AI systems, thereby democratizing access to high-performing AI.

AI has proven highly successful at urban planning analysis -- learning patterns from data to predict future conditions. The next frontier is AI-assisted decision-making: agents that recommend sites, allocate resources, and evaluate trade-offs while reasoning transparently about constraints and stakeholder values. Recent breakthroughs in reasoning AI -- CoT prompting, ReAct, and multi-agent collaboration frameworks -- now make this vision achievable. This position paper presents the Agentic Urban Planning AI Framework for reasoning-capable planning agents that integrates three cognitive layers (Perception, Foundation, Reasoning) with six logic components (Analysis, Generation, Verification, Evaluation, Collaboration, Decision) through a multi-agents collaboration framework. We demonstrate why planning decisions require explicit reasoning capabilities that are value-based (applying normative principles), rule-grounded (guaranteeing constraint satisfaction), and explainable (generating transparent justifications) -- requirements that statistical learning alone cannot fulfill. We compare reasoning agents with statistical learning, present a comprehensive architecture with benchmark evaluation metrics, and outline critical research challenges. This framework shows how AI agents can augment human planners by systematically exploring solution spaces, verifying regulatory compliance, and deliberating over trade-offs transparently -- not replacing human judgment but amplifying it with computational reasoning capabilities.