Chimeric antigen receptor T-cell (CAR-T) therapy represents a paradigm shift in cancer treatment, yet development timelines of 8-12 years and clinical attrition rates exceeding 40-60% highlight critical inefficiencies in target selection, safety assessment, and molecular optimization. We present Bio AI Agent, a multi-agent artificial intelligence system powered by large language models that enables autonomous CAR-T development through collaborative specialized agents. The system comprises six autonomous agents: Target Selection Agent for multi-parametric antigen prioritization across >10,000 cancer-associated targets, Toxicity Prediction Agent for comprehensive safety profiling integrating tissue expression atlases and pharmacovigilance databases, Molecular Design Agent for rational CAR engineering, Patent Intelligence Agent for freedom-to-operate analysis, Clinical Translation Agent for regulatory compliance, and Decision Orchestration Agent for multi-agent coordination. Retrospective validation demonstrated autonomous identification of high-risk targets including FcRH5 (hepatotoxicity) and CD229 (off-tumor toxicity), patent infringement risks for CD38+SLAMF7 combinations, and generation of comprehensive development roadmaps. By enabling parallel processing, specialized reasoning, and autonomous decision-making superior to monolithic AI systems, Bio AI Agent addresses critical gaps in precision oncology development and has potential to accelerate translation of next-generation immunotherapies from discovery to clinic.

AI agents capable of controlling user interfaces have the potential to transform human interaction with digital devices. To accelerate this transformation, two fundamental building blocks are essential: high-quality datasets that enable agents to achieve complex and human-relevant goals, and robust evaluation methods that allow researchers and practitioners to rapidly enhance agent performance. In this paper, we introduce DigiData, a large-scale, high-quality, diverse, multi-modal dataset designed for training mobile control agents. Unlike existing datasets, which derive goals from unstructured interactions, DigiData is meticulously constructed through comprehensive exploration of app features, resulting in greater diversity and higher goal complexity. Additionally, we present DigiData-Bench, a benchmark for evaluating mobile control agents on real-world complex tasks. We demonstrate that the commonly used step-accuracy metric falls short in reliably assessing mobile control agents and, to address this, we propose dynamic evaluation protocols and AI-powered evaluations as rigorous alternatives for agent assessment. Our contributions aim to significantly advance the development of mobile control agents, paving the way for more intuitive and effective human-device interactions.

We consider a scenario where a team of two unmanned aerial vehicles (UAVs) pursue an evader UAV within an urban environment. Each agent has a limited view of their environment where buildings can occlude their field-of-view. Additionally, the pursuer team is agnostic about the evader in terms of its initial and final location, and the behavior of the evader. Consequently, the team needs to gather information by searching the environment and then track it to eventually intercept. To solve this multi-player, partially-observable, pursuit-evasion game, we develop a two-phase neuro-symbolic algorithm centered around the principle of bounded rationality. First, we devise an offline approach using deep reinforcement learning to progressively train adversarial policies for the pursuer team against fictitious evaders. This creates $k$-levels of rationality for each agent in preparation for the online phase. Then, we employ an online classification algorithm to determine a "best guess" of our current opponent from the set of iteratively-trained strategic agents and apply the best player response. Using this schema, we improved average performance when facing a random evader in our environment.

The complexity of Structured Query Language (SQL) and the specialized nature of geospatial functions in tools like PostGIS present significant barriers to non-experts seeking to analyze spatial data. While Large Language Models (LLMs) offer promise for translating natural language into SQL (Text-to-SQL), single-agent approaches often struggle with the semantic and syntactic complexities of spatial queries. To address this, we propose a multi-agent framework designed to accurately translate natural language questions into spatial SQL queries. The framework integrates several innovative components, including a knowledge base with programmatic schema profiling and semantic enrichment, embeddings for context retrieval, and a collaborative multi-agent pipeline as its core. This pipeline comprises specialized agents for entity extraction, metadata retrieval, query logic formulation, SQL generation, and a review agent that performs programmatic and semantic validation of the generated SQL to ensure correctness (self-verification). We evaluate our system using both the non-spatial KaggleDBQA benchmark and a new, comprehensive SpatialQueryQA benchmark that includes diverse geometry types, predicates, and three levels of query complexity. On KaggleDBQA, the system achieved an overall accuracy of 81.2% (221 out of 272 questions) after the review agent's review and corrections. For spatial queries, the system achieved an overall accuracy of 87.7% (79 out of 90 questions), compared with 76.7% without the review agent. Beyond accuracy, results also show that in some instances the system generates queries that are more semantically aligned with user intent than those in the benchmarks. This work makes spatial analysis more accessible, and provides a robust, generalizable foundation for spatial Text-to-SQL systems, advancing the development of autonomous GIS.

Evacuation simulation is essential for building safety design, ensuring properly planned evacuation routes. However, traditional evacuation simulation relies heavily on refined modeling with extensive parameters, making it challenging to adopt such methods in a rapid iteration process in early design stages. Thus, this study proposes DiffEvac, a novel method to learn building evacuation patterns based on Generative Models (GMs), for efficient evacuation simulation and enhanced safety design. Initially, a dataset of 399 diverse functional layouts and corresponding evacuation heatmaps of buildings was established. Then, a decoupled feature representation is proposed to embed physical features like layouts and occupant density for GMs. Finally, a diffusion model based on image prompts is proposed to learn evacuation patterns from simulated evacuation heatmaps. Compared to existing research using Conditional GANs with RGB representation, DiffEvac achieves up to a 37.6% improvement in SSIM, 142% in PSNR, and delivers results 16 times faster, thereby cutting simulation time to 2 minutes. Case studies further demonstrate that the proposed method not only significantly enhances the rapid design iteration and adjustment process with efficient evacuation simulation but also offers new insights and technical pathways for future safety optimization in intelligent building design. The research implication is that the approach lowers the modeling burden, enables large-scale what-if exploration, and facilitates coupling with multi-objective design tools.

Generative Agentic AI systems are emerging as a powerful paradigm for automating complex, multi-step tasks. However, many existing frameworks for building these systems introduce significant complexity, a steep learning curve, and substantial boilerplate code, hindering rapid prototyping and deployment. This paper introduces simpliflow, a lightweight, open-source Python framework designed to address these challenges. simpliflow enables the rapid development and orchestration of linear, deterministic agentic workflows through a declarative, JSON-based configuration. Its modular architecture decouples agent management, workflow execution, and post-processing, promoting ease of use and extensibility. By integrating with LiteLLM, it supports over 100 Large Language Models (LLMs) out-of-the-box. We present the architecture, operational flow, and core features of simpliflow, demonstrating its utility through diverse use cases ranging from software development simulation to real-time system interaction. A comparative analysis with prominent frameworks like LangChain and AutoGen highlights simpliflow's unique position as a tool optimized for simplicity, control, and speed in deterministic workflow environments.

We investigate the integration of attention maps from a pre-trained Vision Transformer into voxel representations to enhance bimanual robotic manipulation. Specifically, we extract attention maps from DINOv2, a self-supervised ViT model, and interpret them as pixel-level saliency scores over RGB images. These maps are lifted into a 3D voxel grid, resulting in voxel-level semantic cues that are incorporated into a behavior cloning policy. When integrated into a state-of-the-art voxel-based policy, our attention-guided featurization yields an average absolute improvement of 8.2% and a relative gain of 21.9% across all tasks in the RLBench bimanual benchmark.

Embodied intelligence systems, which enhance agent capabilities through continuous environment interactions, have garnered significant attention from both academia and industry. Vision-Language-Action models, inspired by advancements in large foundation models, serve as universal robotic control frameworks that substantially improve agent-environment interaction capabilities in embodied intelligence systems. This expansion has broadened application scenarios for embodied AI robots. This survey comprehensively reviews VLA models for embodied manipulation. Firstly, it chronicles the developmental trajectory of VLA architectures. Subsequently, we conduct a detailed analysis of current research across 5 critical dimensions: VLA model structures, training datasets, pre-training methods, post-training methods, and model evaluation. Finally, we synthesize key challenges in VLA development and real-world deployment, while outlining promising future research directions.

In ethics, individual responsibility is often defined through Frankfurt's principle of alternative possibilities. This definition is not adequate in a group decision-making setting because it often results in the lack of a responsible party or "responsibility gap''. One of the existing approaches to address this problem is to consider group responsibility. Another, recently proposed, approach is "higher-order'' responsibility. The paper considers the problem of deciding if higher-order responsibility up to degree $d$ is enough to close the responsibility gap. The main technical result is that this problem is $Π_{2d+1}$-complete.

We characterize zonal ancillary market coupling relying on noncooperative game theory. To that purpose, we formulate the ancillary market as a multi-leader single follower bilevel problem, that we subsequently cast as a generalized Nash game with side constraints and nonconvex feasibility sets. We determine conditions for equilibrium existence and show that the game has a generalized potential game structure. To compute market equilibrium, we rely on two exact approaches: an integrated optimization approach and Gauss-Seidel best-response, that we compare against multi-agent deep reinforcement learning. On real data from Germany and Austria, simulations indicate that multi-agent deep reinforcement learning achieves the smallest convergence rate but requires pretraining, while best-response is the slowest. On the economics side, multi-agent deep reinforcement learning results in smaller market costs compared to the exact methods, but at the cost of higher variability in the profit allocation among stakeholders. Further, stronger coupling between zones tends to reduce costs for larger zones.