Electronic Health Records (EHRs) have been increasingly used as real-world evidence (RWE) to support the discovery and validation of new drug indications. This paper surveys current approaches to EHR-based drug repurposing, covering data sources, processing methodologies, and representation techniques. It discusses study designs and statistical frameworks for evaluating drug efficacy. Key challenges in validation are discussed, with emphasis on the role of large language models (LLMs) and target trial emulation. By synthesizing recent developments and methodological advances, this work provides a foundational resource for researchers aiming to translate real-world data into actionable drug-repurposing evidence.

This paper presents a pioneering exploration of reinforcement learning (RL) via group relative policy optimization for unified multimodal large language models (ULMs), aimed at simultaneously reinforcing generation and understanding capabilities. Through systematic pilot studies, we uncover the significant potential of ULMs to enable the synergistic co-evolution of dual capabilities within a shared policy optimization framework. Building on this insight, we introduce CoRL, a co-reinforcement learning framework comprising a unified RL stage for joint optimization and a refined RL stage for task-specific enhancement. With the proposed CoRL, our resulting model, ULM-R1, achieves average improvements of 7% on three text-to-image generation datasets and 23% on nine multimodal understanding benchmarks. These results demonstrate the effectiveness of CoRL and highlight the substantial benefit of reinforcement learning in facilitating cross-task synergy and optimization for ULMs. Code is available at https://github.com/mm-vl/ULM-R1.

An important task in machine learning (ML) research is comparing prior work, which is often performed via ML leaderboards: a tabular overview of experiments with comparable conditions (e.g., same task, dataset, and metric). However, the growing volume of literature creates challenges in creating and maintaining these leaderboards. To ease this burden, researchers have developed methods to extract leaderboard entries from research papers for automated leaderboard curation. Yet, prior work varies in problem framing, complicating comparisons and limiting real-world applicability. In this position paper, we present the first overview of Automatic Leaderboard Generation (ALG) research, identifying fundamental differences in assumptions, scope, and output formats. We propose an ALG unified conceptual framework to standardise how the ALG task is defined. We offer ALG benchmarking guidelines, including recommendations for datasets and metrics that promote fair, reproducible evaluation. Lastly, we outline challenges and new directions for ALG, such as, advocating for broader coverage by including all reported results and richer metadata.

Retrieval of legal knowledge by the general public is a challenging problem due to the technicality of the professional knowledge and the lack of fundamental understanding by laypersons on the subject. Traditional information retrieval techniques assume that users are capable of formulating succinct and precise queries for effective document retrieval. In practice, however, the wide gap between the highly technical contents and untrained users makes legal knowledge retrieval very difficult. We propose a methodology, called QBR, which employs a Questions Bank (QB) as an effective medium for bridging the knowledge gap. We show how the QB is used to derive training samples to enhance the embedding of knowledge units within documents, which leads to effective fine-grained knowledge retrieval. We discuss and evaluate through experiments various advantages of QBR over traditional methods. These include more accurate, efficient, and explainable document retrieval, better comprehension of retrieval results, and highly effective fine-grained knowledge retrieval. We also present some case studies and show that QBR achieves social impact by assisting citizens to resolve everyday legal concerns.

Model Inversion (MI) attacks aim to reconstruct information from private training data by exploiting access to machine learning models T. To evaluate such attacks, the standard evaluation framework relies on an evaluation model E, trained under the same task design as T. This framework has become the de facto standard for assessing progress in MI research, used across nearly all recent MI studies without question. In this paper, we present the first in-depth study of this evaluation framework. In particular, we identify a critical issue of this standard framework: Type-I adversarial examples. These are reconstructions that do not capture the visual features of private training data, yet are still deemed successful by T and ultimately transferable to E. Such false positives undermine the reliability of the standard MI evaluation framework. To address this issue, we introduce a new MI evaluation framework that replaces the evaluation model E with advanced Multimodal Large Language Models (MLLMs). By leveraging their general-purpose visual understanding, our MLLM-based framework does not depend on training of shared task design as in T, thus reducing Type-I transferability and providing more faithful assessments of reconstruction success. Using our MLLM-based evaluation framework, we reevaluate 27 diverse MI attack setups and empirically reveal consistently high false positive rates under the standard evaluation framework. Importantly, we demonstrate that many state-of-the-art (SOTA) MI methods report inflated attack accuracy, indicating that actual privacy leakage is significantly lower than previously believed. By uncovering this critical issue and proposing a robust solution, our work enables a reassessment of progress in MI research and sets a new standard for reliable and robust evaluation. Code can be found in https://github.com/hosytuyen/MI-Eval-MLLM

We introduce AutoJudge, a method that accelerates large language model (LLM) inference with task-specific lossy speculative decoding. Instead of matching the original model output distribution token-by-token, we identify which of the generated tokens affect the downstream quality of the response, relaxing the distribution match guarantee so that the "unimportant" tokens can be generated faster. Our approach relies on a semi-greedy search algorithm to test which of the mismatches between target and draft models should be corrected to preserve quality and which ones may be skipped. We then train a lightweight classifier based on existing LLM embeddings to predict, at inference time, which mismatching tokens can be safely accepted without compromising the final answer quality. We evaluate the effectiveness of AutoJudge with multiple draft/target model pairs on mathematical reasoning and programming benchmarks, achieving significant speedups at the cost of a minor accuracy reduction. Notably, on GSM8k with the Llama 3.1 70B target model, our approach achieves up to $\approx2\times$ speedup over speculative decoding at the cost of $\le 1\%$ drop in accuracy. When applied to the LiveCodeBench benchmark, AutoJudge automatically detects programming-specific important tokens, accepting $\ge 25$ tokens per speculation cycle at $2\%$ drop in Pass@1. Our approach requires no human annotation and is easy to integrate with modern LLM inference frameworks.

Small Language Models (SLMs) have potential to be used for automatically labelling and identifying aspects of text data for medicine/health-related purposes from documents and the web. As their resource requirements are significantly lower than Large Language Models (LLMs), these can be deployed potentially on more types of devices. SLMs often are benchmarked on health/medicine-related tasks, such as MedQA, although performance on these can vary especially depending on the size of the model in terms of number of parameters. Furthermore, these test results may not necessarily reflect real-world performance regarding the automatic labelling or identification of texts in documents and the web. As a result, we compared topic-relatedness scores from Microsofts phi-3-mini-4k-instruct SLM to the topic-relatedness scores from 7 human evaluators on 1144 samples of medical/health-related texts and 1117 samples of sports injury-related texts. These texts were from a larger dataset of about 9 million news headlines, each of which were processed and assigned scores by phi-3-mini-4k-instruct. Our sample was selected (filtered) based on 1 (low filtering) or more (high filtering) Boolean conditions on the phi-3 SLM scores. We found low-moderate significant correlations between the scores from the SLM and human evaluators for sports injury texts with low filtering (\r{ho} = 0.3413, p < 0.001) and medicine/health texts with high filtering (\r{ho} = 0.3854, p < 0.001), and low significant correlation for medicine/health texts with low filtering (\r{ho} = 0.2255, p < 0.001). There was negligible, insignificant correlation for sports injury-related texts with high filtering (\r{ho} = 0.0318, p = 0.4466).

Retrieval-augmented generation (RAG) is instrumental for inhibiting hallucinations in large language models (LLMs) through the use of a factual knowledge base (KB). Although PDF documents are prominent sources of knowledge, text-based RAG pipelines are ineffective at capturing their rich multi-modal information. In contrast, visual document RAG (VD-RAG) uses screenshots of document pages as the KB, which has been shown to achieve state-of-the-art results. However, by introducing the image modality, VD-RAG introduces new attack vectors for adversaries to disrupt the system by injecting malicious documents into the KB. In this paper, we demonstrate the vulnerability of VD-RAG to poisoning attacks targeting both retrieval and generation. We define two attack objectives and demonstrate that both can be realized by injecting only a single adversarial image into the KB. Firstly, we introduce a targeted attack against one or a group of queries with the goal of spreading targeted disinformation. Secondly, we present a universal attack that, for any potential user query, influences the response to cause a denial-of-service in the VD-RAG system. We investigate the two attack objectives under both white-box and black-box assumptions, employing a multi-objective gradient-based optimization approach as well as prompting state-of-the-art generative models. Using two visual document datasets, a diverse set of state-of-the-art retrievers (embedding models) and generators (vision language models), we show VD-RAG is vulnerable to poisoning attacks in both the targeted and universal settings, yet demonstrating robustness to black-box attacks in the universal setting.

Object-oriented representations in reinforcement learning have shown promise in transfer learning, with previous research introducing a propositional object-oriented framework that has provably efficient learning bounds with respect to sample complexity. However, this framework has limitations in terms of the classes of tasks it can efficiently learn. In this paper we introduce a novel deictic object-oriented framework that has provably efficient learning bounds and can solve a broader range of tasks. Additionally, we show that this framework is capable of zero-shot transfer of transition dynamics across tasks and demonstrate this empirically for the Taxi and Sokoban domains.

Zero-shot learning (ZSL) aims to recognize unseen object classes without any training samples, which can be regarded as a form of transfer learning from seen classes to unseen ones. This is made possible by learning a projection between a feature space and a semantic space (e.g.