OpenAI, the creator of ChatGPT, is teaming up with Abu Dhabi's leading artificial intelligence firm as part of an expansion within the United Arab Emirates and the broader region. The partnership with G42, which is chaired by the UAE's influential national security adviser Sheikh Tahnoon bin Zayed Al Nahyan, will focus on delivering OpenAI's generative AI models across sectors spanning financial services to energy and healthcare. "Leveraging G42's industry expertise, we aim to empower businesses and communities with effective solutions that resonate with the nuances of the region," said Sam Altman, co-founder and chief executive officer of San Francisco-based OpenAI. The partnership is a "convergence of value and vision," G42 CEO Peng Xiao said. The companies didn't disclose financial details of their collaboration. It's partnering with Cerebras Systems Inc., which recently built the first of nine AI supercomputers as an alternative to systems using Nvidia Corp. technology.

ChatGPT can provide researchers with useful feedback on their papers, suggesting it could supplement the human peer review process that helps scientific journals decide which studies to publish. But others are sceptical that ChatGPT could play a role in peer review. Peer review is a critical component of scientific publishing. However, many journals and research conferences are struggling to recruit enough human peer reviewers – who typically volunteer their time for free – to evaluate the growing number of submitted papers.

It's a perennial question at WIRED: Tech got us into this mess, can it get us out? That's particularly true when it comes to climate change. As the weather becomes more extreme and unpredictable, there are hopes that artificial intelligence--that other existential threat--might be part of the solution. DeepMind, the Google-owned artificial intelligence lab, has been using its AI expertise to tackle the climate change problem in three different ways, as Sims Witherspoon, DeepMind's climate action lead, explained in an interview ahead of her talk at WIRED Impact in London on November 21. This conversation has been edited for clarity and length. WIRED: How can AI help us tackle climate change?

Existing text scaling methods often require a large corpus, struggle with short texts, or require labeled data. We develop a text scaling method that leverages the pattern recognition capabilities of generative large language models (LLMs). Specifically, we propose concept-guided chain-of-thought (CGCoT), which uses prompts designed to summarize ideas and identify target parties in texts to generate concept-specific breakdowns, in many ways similar to guidance for human coder content analysis. CGCoT effectively shifts pairwise text comparisons from a reasoning problem to a pattern recognition problem. We then pairwise compare concept-specific breakdowns using an LLM. We use the results of these pairwise comparisons to estimate a scale using the Bradley-Terry model. We use this approach to scale affective speech on Twitter. Our measures correlate more strongly with human judgments than alternative approaches like Wordfish. Besides a small set of pilot data to develop the CGCoT prompts, our measures require no additional labeled data and produce binary predictions comparable to a RoBERTa-Large model fine-tuned on thousands of human-labeled tweets. We demonstrate how combining substantive knowledge with LLMs can create state-of-the-art measures of abstract concepts.

Recent advancements in Large Language Models (LLMs) have expanded the horizons of natural language understanding and generation. Notably, the output control and alignment with the input of LLMs can be refined through instruction tuning. However, as highlighted in several studies, low-quality data in the training set are usually detrimental to instruction tuning, resulting in inconsistent or even misleading LLM outputs. We propose a novel method, termed "reflection-tuning," which addresses the problem by self-improvement and judging capabilities of LLMs. This approach utilizes an oracle LLM to recycle the original training data by introspecting and enhancing the quality of instructions and responses in the data. Extensive experiments on widely used evaluation benchmarks show that LLMs trained with our recycled data outperform those trained with existing datasets in various benchmarks.

The patient-centered medical dialogue systems strive to offer diagnostic interpretation services to users who are less knowledgeable about medical knowledge, through emphasizing the importance of providing responses specific to the patients. It is difficult for the large language models (LLMs) to guarantee the specificity of responses in spite of its promising performance even in some tasks in medical field. Inspired by in-context learning, we propose PlugMed, a Plug-and-Play Medical Dialogue System, for addressing this challenge. PlugMed is equipped with two modules, the prompt generation (PG) module and the response ranking (RR) module, to enhances LLMs' dialogue strategies for improving the specificity of the dialogue. The PG module is designed to stimulate the imitative ability of LLMs by providing them with real dialogues from similar patients as prompts. The RR module incorporates fine-tuned small model as response filter to enable the selection of appropriate responses generated by LLMs. Furthermore, we introduce a new evaluation method based on matching both user's intent and high-frequency medical term to effectively assess the specificity of the responses. We conduct experimental evaluations on three medical dialogue datasets, and the results, including both automatic and human evaluation, demonstrate the effectiveness of our approach.

We call into question the recently popularized method of direct model editing as a means of correcting factual errors in LLM generations. We contrast model editing with three similar but distinct approaches that pursue better defined objectives: (1) retrieval-based architectures, which decouple factual memory from inference and linguistic capabilities embodied in LLMs; (2) concept erasure methods, which aim at preventing systemic bias in generated text; and (3) attribution methods, which aim at grounding generations into identified textual sources. We argue that direct model editing cannot be trusted as a systematic remedy for the disadvantages inherent to LLMs, and while it has proven potential in improving model explainability, it opens risks by reinforcing the notion that models can be trusted for factuality. We call for cautious promotion and application of model editing as part of the LLM deployment process, and for responsibly limiting the use cases of LLMs to those not relying on editing as a critical component.

Understanding protein interactions and pathway knowledge is crucial for unraveling the complexities of living systems and investigating the underlying mechanisms of biological functions and complex diseases. While existing databases provide curated biological data from literature and other sources, they are often incomplete and their maintenance is labor-intensive, necessitating alternative approaches. In this study, we propose to harness the capabilities of large language models to address these issues by automatically extracting such knowledge from the relevant scientific literature. Toward this goal, in this work, we investigate the effectiveness of different large language models in tasks that involve recognizing protein interactions, identifying genes associated with pathways affected by low-dose radiation, and gene regulatory relations. We thoroughly evaluate the performance of various models, highlight the significant findings, and discuss both the future opportunities and the remaining challenges associated with this approach. The code and data are available at: https://github.com/boxorange/BioIE-LLM

Large language models (LLMs) have been successfully applied to software engineering tasks, including program repair. However, their application in search-based techniques such as Genetic Improvement (GI) is still largely unexplored. In this paper, we evaluate the use of LLMs as mutation operators for GI to improve the search process. We expand the Gin Java GI toolkit to call OpenAI's API to generate edits for the JCodec tool. We randomly sample the space of edits using 5 different edit types. We find that the number of patches passing unit tests is up to 75% higher with LLM-based edits than with standard Insert edits. Further, we observe that the patches found with LLMs are generally less diverse compared to standard edits. We ran GI with local search to find runtime improvements. Although many improving patches are found by LLM-enhanced GI, the best improving patch was found by standard GI.

Generative models trained on internet-scale data are capable of generating novel and realistic texts, images, and videos. A natural next question is whether these models can advance science, for example by generating novel stable materials. Traditionally, models with explicit structures (e.g., graphs) have been used in modeling structural relationships in scientific data (e.g., atoms and bonds in crystals), but generating structures can be difficult to scale to large and complex systems. Another challenge in generating materials is the mismatch between standard generative modeling metrics and downstream applications. For instance, common metrics such as the reconstruction error do not correlate well with the downstream goal of discovering stable materials. In this work, we tackle the scalability challenge by developing a unified crystal representation that can represent any crystal structure (UniMat), followed by training a diffusion probabilistic model on these UniMat representations. Our empirical results suggest that despite the lack of explicit structure modeling, UniMat can generate high fidelity crystal structures from larger and more complex chemical systems, outperforming previous graph-based approaches under various generative modeling metrics. To better connect the generation quality of materials to downstream applications, such as discovering novel stable materials, we propose additional metrics for evaluating generative models of materials, including per-composition formation energy and stability with respect to convex hulls through decomposition energy from Density Function Theory (DFT). Lastly, we show that conditional generation with UniMat can scale to previously established crystal datasets with up to millions of crystals structures, outperforming random structure search (the current leading method for structure discovery) in discovering new stable materials.