Recently, the impressive performance of large language models (LLMs) on a wide range of tasks has attracted an increasing number of attempts to apply LLMs in drug discovery. However, molecule optimization, a critical task in the drug discovery pipeline, is currently an area that has seen little involvement from LLMs. Most of existing approaches focus solely on capturing the underlying patterns in chemical structures provided by the data, without taking advantage of expert feedback. These non-interactive approaches overlook the fact that the drug discovery process is actually one that requires the integration of expert experience and iterative refinement. To address this gap, we propose DrugAssist, an interactive molecule optimization model which performs optimization through humanmachine dialogue by leveraging LLM's strong interactivity and generalizability. DrugAssist has achieved leading results in both single and multiple property optimization, simultaneously showcasing immense potential in transferability and iterative optimization. In addition, we publicly release a large instructionbased dataset called "MolOpt-Instructions" for fine-tuning language models on molecule optimization tasks. Figure 1: The illustration of our proposed DrugAssist model framework, which focus on optimizing molecules through human-machine dialogue. Recently, generative artificial intelligence has made remarkable strides in the field of natural language processing (NLP), particularly with the advent of Large Language Models (LLMs) such as GPT (Generative Pre-trained Transformer) (Radford et al., 2019). These models have demonstrated impressive capabilities in a wide range of tasks, extending far beyond everyday communication and question-answering scenarios.

Current prompting approach for language model inference mainly rely on Language Model's (LLM) autonomous exploration of reasoning paths, confronts an inevitable retracing operation when erroneous routes are encountered. This is followed by the pursuit of alternative reasoning paths. However, humans are adept at abstracting optimal solutions from problems, thereby facilitating swift and precise reasoning for similar problems resolution. In light of this, we delves into the potential of harnessing expert knowledge to enhance problem-solving within LLMs. We introduce a novel paradigm, the State Machine of Thought (SMoT), which employs predefined state machines to furnish LLMs with efficient reasoning paths, thereby eliminating fruitless exploration. Furthermore, we propose a multi-agent mechanism that assigns different objectives to agents, aiming to enhance the accuracy of SMoT reasoning. The experimental results, derived from an array reasoning task, reveal that SMoT realizes an extraordinary accuracy of 95\%, surpassing the performance of the state-of-the-art baselines.

Audio Question Answering (AQA) constitutes a pivotal task in which machines analyze both audio signals and natural language questions to produce precise natural language answers. The significance of possessing high-quality, diverse, and extensive AQA datasets cannot be overstated when aiming for the precision of an AQA system. While there has been notable focus on developing accurate and efficient AQA models, the creation of high-quality, diverse, and extensive datasets for the specific task at hand has not garnered considerable attention. To address this challenge, this work makes several contributions. We introduce a scalable AQA data generation pipeline, denoted as the AQUALLM framework, which relies on Large Language Models (LLMs). This framework utilizes existing audio-caption annotations and incorporates state-of-the-art LLMs to generate expansive, high-quality AQA datasets. Additionally, we present three extensive and high-quality benchmark datasets for AQA, contributing significantly to the progression of AQA research. AQA models trained on the proposed datasets set superior benchmarks compared to the existing state-of-the-art. Moreover, models trained on our datasets demonstrate enhanced generalizability when compared to models trained using human-annotated AQA data. Code and datasets will be accessible on GitHub~\footnote{\url{https://github.com/swarupbehera/AQUALLM}}.

This paper addresses the privacy and security concerns associated with deep neural language models, which serve as crucial components in various modern AI-based applications. These models are often used after being pre-trained and fine-tuned for specific tasks, with deployment on servers accessed through the internet. However, this introduces two fundamental risks: (a) the transmission of user inputs to the server via the network gives rise to interception vulnerabilities, and (b) privacy concerns emerge as organizations that deploy such models store user data with restricted context. To address this, we propose a novel method to adapt and fine-tune transformer-based language models on passkey-encrypted user-specific text. The original pre-trained language model first undergoes a quick adaptation (without any further pre-training) with a series of irreversible transformations applied to the tokenizer and token embeddings. This enables the model to perform inference on encrypted inputs while preventing reverse engineering of text from model parameters and intermediate outputs. After adaptation, models are fine-tuned on encrypted versions of existing training datasets. Experimental evaluation employing adapted versions of renowned models (e.g., BERT, RoBERTa) across established benchmark English and multilingual datasets for text classification and sequence labeling shows that encrypted models achieve performance parity with their original counterparts. This serves to safeguard performance, privacy, and security cohesively.

Nature is an amorphous concept. Yet, it is essential for the planet's well-being to understand how the economy interacts with it. To address the growing demand for information on corporate nature disclosure, we provide datasets and classifiers to detect nature communication by companies. We ground our approach in the guidelines of the Taskforce on Nature-related Financial Disclosures (TNFD). Particularly, we focus on the specific dimensions of water, forest, and biodiversity. For each dimension, we create an expert-annotated dataset with 2,200 text samples and train classifier models. Furthermore, we show that nature communication is more prevalent in hotspot areas and directly effected industries like agriculture and utilities. Our approach is the first to respond to calls to assess corporate nature communication on a large scale.

Before a word is generated, the complete vocabulary of the LLM is split in two disjunct lists With the rise of large language models (LLMs) labelled green and red. This split is pseudo-random, where and concerns about potential misuse, watermarks the seed is determined by the previous word(s). Green-list for generative LLMs have recently attracted much words are then sampled with a higher probability than the attention. An important aspect of such watermarks original LLM prescribes, and red-list words with a lower is the trade-off between their identifiability probability. A detector with knowledge of the pseudorandom and their impact on the quality of the generated green-red split can count the number of green-list text. This paper introduces a systematic approach words in a text. If this number is larger than one would expect to this trade-off in terms of a multi-objective optimization from a text generated without knowledge of the greenred problem. For a large class of robust, efficient split (e.g., a human-generated text), the null hypothesis watermarks, the associated Pareto optimal is rejected and the text is attributed to an LLM.

While Large Language Models (LLMs) like ChatGPT and GPT-4 have demonstrated exceptional proficiency in natural language processing, their efficacy in addressing complex, multifaceted tasks remains limited. A growing area of research focuses on LLM-based agents equipped with external tools capable of performing diverse tasks. However, existing LLM-based agents only support a limited set of tools which is unable to cover a diverse range of user queries, especially for those involving expertise domains. It remains a challenge for LLM-based agents to extend their tools autonomously when confronted with various user queries. As GitHub has hosted a multitude of repositories which can be seen as a good resource for tools, a promising solution is that LLM-based agents can autonomously integrate the repositories in GitHub according to the user queries to extend their tool set. In this paper, we introduce GitAgent, an agent capable of achieving the autonomous tool extension from GitHub. GitAgent follows a four-phase procedure to incorporate repositories and it can learn human experience by resorting to GitHub Issues/PRs to solve problems encountered during the procedure. Experimental evaluation involving 30 user queries demonstrates GitAgent's effectiveness, achieving a 69.4% success rate on average.

We design probes trained on the internal representations of a transformer language model that are predictive of its hallucinatory behavior on in-context generation tasks. To facilitate this detection, we create a span-annotated dataset of organic and synthetic hallucinations over several tasks. We find that probes trained on the force-decoded states of synthetic hallucinations are generally ecologically invalid in organic hallucination detection. Furthermore, hidden state information about hallucination appears to be task and distribution-dependent. Intrinsic and extrinsic hallucination saliency varies across layers, hidden state types, and tasks; notably, extrinsic hallucinations tend to be more salient in a transformer's internal representations. Outperforming multiple contemporary baselines, we show that probing is a feasible and efficient alternative to language model hallucination evaluation when model states are available.

State-of-the-art language models are becoming increasingly large in an effort to achieve the highest performance on large corpora of available textual data. However, the sheer size of the Transformer architectures makes it difficult to deploy models within computational, environmental or device-specific constraints. We explore data-driven compression of existing pretrained models as an alternative to training smaller models from scratch. To do so, we scale Kronecker-factored curvature approximations of the target loss landscape to large language models. In doing so, we can compute both the dynamic allocation of structures that can be removed as well as updates of remaining weights that account for the removal. We provide a general framework for unstructured, semi-structured and structured pruning and improve upon weight updates to capture more correlations between weights, while remaining computationally efficient. Experimentally, our method can prune rows and columns from a range of OPT models and Llamav2-7B by 20%-30%, with a negligible loss in performance, and achieve state-of-the-art results in unstructured and semi-structured pruning of large language models. Recent advancements in language modeling (Vaswani et al., 2017) allow fitting large language models (LLMs) with millions or even billions of parameters (such as OPT (Zhang et al., 2022) and Llama 2 (Touvron et al., 2023)) on big text corpora achieving high performance.

Prior work in style-controlled text generation has focused on tasks such as emulating the style of prolific literary authors, producing formal or informal text, and the degree of toxicity of generated text. Plentiful demonstrations of these styles are available, and as a result modern language models are often able to emulate them, either via prompting or discriminative control. However, in applications such as writing assistants, it is desirable for language models to produce text in an author-specific style on the basis of a small writing sample. We find that instruction-tuned language models can struggle to reproduce author-specific style demonstrated in a prompt. Instead, we propose to guide a language model to generate text in a target style using contrastively-trained representations that capture stylometric features. A central challenge in doing so is that an author's writing is characterized by surprising token choices under a generic language model. To reconcile this tension, we combine generative re-scoring to achieve an author-specific model, with discriminative control to ensure style consistency at the sequence-level. The combination of these approaches is found to be particularly effective at adhering to an author-specific style in a variety of conditions, including unconditional generation and style transfer, and is applicable to any underlying language model without requiring fine-tuning.