Instruction Tuning has the potential to stimulate or enhance specific capabilities of large language models (LLMs). However, achieving the right balance of data is crucial to prevent catastrophic forgetting and interference between tasks. To address these limitations and enhance training flexibility, we propose the Mixture-of-LoRAs (MoA) architecture which is a novel and parameter-efficient tuning method designed for multi-task learning with LLMs. In this paper, we start by individually training multiple domain-specific LoRA modules using corresponding supervised corpus data. These LoRA modules can be aligned with the expert design principles observed in Mixture-of-Experts (MoE). Subsequently, we combine the multiple LoRAs using an explicit routing strategy and introduce domain labels to facilitate multi-task learning, which help prevent interference between tasks and ultimately enhances the performance of each individual task. Furthermore, each LoRA model can be iteratively adapted to a new domain, allowing for quick domain-specific adaptation. Experiments on diverse tasks demonstrate superior and robust performance, which can further promote the wide application of domain-specific LLMs.

The integration of deep learning, particularly AI-Generated Content, with high-quality data derived from ab initio calculations has emerged as a promising avenue for transforming the landscape of scientific research. However, the challenge of designing molecular drugs or materials that incorporate multi-modality prior knowledge remains a critical and complex undertaking. Specifically, achieving a practical molecular design necessitates not only meeting the diversity requirements but also addressing structural and textural constraints with various symmetries outlined by domain experts. In this article, we present an innovative approach to tackle this inverse design problem by formulating it as a multi-modality guidance generation/optimization task. Our proposed solution involves a textural-structure alignment symmetric diffusion framework for the implementation of molecular generation/optimization tasks, namely 3DToMolo. 3DToMolo aims to harmonize diverse modalities, aligning them seamlessly to produce molecular structures adhere to specified symmetric structural and textural constraints by experts in the field. Experimental trials across three guidance generation settings have shown a superior hit generation performance compared to state-of-the-art methodologies. Moreover, 3DToMolo demonstrates the capability to generate novel molecules, incorporating specified target substructures, without the need for prior knowledge. This work not only holds general significance for the advancement of deep learning methodologies but also paves the way for a transformative shift in molecular design strategies. 3DToMolo creates opportunities for a more nuanced and effective exploration of the vast chemical space, opening new frontiers in the development of molecular entities with tailored properties and functionalities.

The growing interest in Large Language Models (LLMs) for specialized applications has revealed a significant challenge: when tailored to specific domains, LLMs tend to experience catastrophic forgetting, compromising their general capabilities and leading to a suboptimal user experience. Additionally, crafting a versatile model for multiple domains simultaneously often results in a decline in overall performance due to confusion between domains. In response to these issues, we present the RolE Prompting Guided Multi-Domain Adaptation (REGA) strategy. This novel approach effectively manages multi-domain LLM adaptation through three key components: 1) Self-Distillation constructs and replays general-domain exemplars to alleviate catastrophic forgetting. 2) Role Prompting assigns a central prompt to the general domain and a unique role prompt to each specific domain to minimize inter-domain confusion during training. 3) Role Integration reuses and integrates a small portion of domain-specific data to the general-domain data, which are trained under the guidance of the central prompt. The central prompt is used for a streamlined inference process, removing the necessity to switch prompts for different domains. Empirical results demonstrate that REGA effectively alleviates catastrophic forgetting and inter-domain confusion. This leads to improved domain-specific performance compared to standard fine-tuned models, while still preserving robust general capabilities.

Graph Structure Learning (GSL) focuses on capturing intrinsic dependencies and interactions among nodes in graph-structured data by generating novel graph structures. Graph Neural Networks (GNNs) have emerged as promising GSL solutions, utilizing recursive message passing to encode node-wise inter-dependencies. However, many existing GSL methods heavily depend on explicit graph structural information as supervision signals, leaving them susceptible to challenges such as data noise and sparsity. In this work, we propose GraphEdit, an approach that leverages large language models (LLMs) to learn complex node relationships in graph-structured data. By enhancing the reasoning capabilities of LLMs through instruction-tuning over graph structures, we aim to overcome the limitations associated with explicit graph structural information and enhance the reliability of graph structure learning. Our approach not only effectively denoises noisy connections but also identifies node-wise dependencies from a global perspective, providing a comprehensive understanding of the graph structure. We conduct extensive experiments on multiple benchmark datasets to demonstrate the effectiveness and robustness of GraphEdit across various settings. We have made our model implementation available at: https://github.com/HKUDS/GraphEdit.

There has been an increasing interest in the alignment of large language models (LLMs) with human values. However, the safety issues of their integration with a vision module, or vision language models (VLMs), remain relatively underexplored. In this paper, we propose a novel jailbreaking attack against VLMs, aiming to bypass their safety barrier when a user inputs harmful instructions. A scenario where our poisoned (image, text) data pairs are included in the training data is assumed. By replacing the original textual captions with malicious jailbreak prompts, our method can perform jailbreak attacks with the poisoned images. Moreover, we analyze the effect of poison ratios and positions of trainable parameters on our attack's success rate. For evaluation, we design two metrics to quantify the success rate and the stealthiness of our attack. Together with a list of curated harmful instructions, a benchmark for measuring attack efficacy is provided. We demonstrate the efficacy of our attack by comparing it with baseline methods.

Large language models (LLMs) have demonstrated remarkable capabilities in problem-solving. However, their proficiency in solving mathematical problems remains inadequate. We propose MathScale, a simple and scalable method to create high-quality mathematical reasoning data using frontier LLMs (e.g., {\tt GPT-3.5}). Inspired by the cognitive mechanism in human mathematical learning, it first extracts topics and knowledge points from seed math questions and then build a concept graph, which is subsequently used to generate new math questions. MathScale exhibits effective scalability along the size axis of the math dataset that we generate. As a result, we create a mathematical reasoning dataset (MathScaleQA) containing two million math question-answer pairs. To evaluate mathematical reasoning abilities of LLMs comprehensively, we construct {\sc MwpBench}, a benchmark of Math Word Problems, which is a collection of ten datasets (including GSM8K and MATH) covering K-12, college, and competition level math problems. We apply MathScaleQA to fine-tune open-source LLMs (e.g., LLaMA-2 and Mistral), resulting in significantly improved capabilities in mathematical reasoning. Evaluated on {\sc MwpBench}, MathScale-7B achieves state-of-the-art performance across all datasets, surpassing its best peers of equivalent size by 42.9\% in micro average accuracy and 43.7\% in macro average accuracy, respectively.

Large language models (LLMs) have proven to be very superior to conventional methods in various tasks. However, their expensive computations and high memory requirements are prohibitive for deployment. Model quantization is an effective method for reducing this overhead. The problem is that in most previous works, the quantized model was calibrated using few samples from the training data, which might affect the generalization of the quantized LLMs to unknown cases and tasks. Hence in this work, we explore an important question: Can we design a data-independent quantization method for LLMs to guarantee its generalization performance? In this work, we propose EasyQuant, a training-free and data-independent weight-only quantization algorithm for LLMs. Our observation indicates that two factors: outliers in the weight and quantization ranges, are essential for reducing the quantization error. Therefore, in EasyQuant, we leave the outliers (less than 1%) unchanged and optimize the quantization range to reduce the reconstruction error. With these methods, we surprisingly find that EasyQuant achieves comparable performance to the original model. Since EasyQuant does not depend on any training data, the generalization performance of quantized LLMs is safely guaranteed. Moreover, EasyQuant can be implemented in parallel so that the quantized model could be attained in a few minutes even for LLMs over 100B. To our best knowledge, we are the first work that achieves almost lossless quantization performance for LLMs under a data-independent setting and our algorithm runs over 10 times faster than the data-dependent methods.

Medical large language models (LLMs) have gained popularity recently due to their significant practical utility. However, most existing research focuses on general medicine, and there is a need for in-depth study of LLMs in specific fields like anesthesiology. To fill the gap, we introduce Hypnos, a Chinese Anesthesia model built upon existing LLMs, e.g., Llama. Hypnos' contributions have three aspects: 1) The data, such as utilizing Self-Instruct, acquired from current LLMs likely includes inaccuracies. Hypnos implements a cross-filtering strategy to improve the data quality. This strategy involves using one LLM to assess the quality of the generated data from another LLM and filtering out the data with low quality. 2) Hypnos employs a general-to-specific training strategy that starts by fine-tuning LLMs using the general medicine data and subsequently improving the fine-tuned LLMs using data specifically from Anesthesiology. The general medical data supplement the medical expertise in Anesthesiology and enhance the effectiveness of Hypnos' generation. 3) We introduce a standardized benchmark for evaluating medical LLM in Anesthesiology. Our benchmark includes both publicly available instances from the Internet and privately obtained cases from the Hospital. Hypnos outperforms other medical LLMs in anesthesiology in metrics, GPT-4, and human evaluation on the benchmark dataset.

Recent studies of the applications of conversational AI tools, such as chatbots powered by large language models (LLMs), to complex real-world knowledge work have shown limitations related to reasoning and multi-step problem solving. Specifically, while existing chatbots simulate shallow reasoning and understanding they are prone to errors as problem complexity increases. The failure of these systems to address complex knowledge work is due to the fact that they do not perform any actual cognition. In this position paper, we present a higher-level framework ("Cognitive AI") for implementing programmatically defined neuro-symbolic cognition above and outside of large language models. Specifically, we propose a dual-layer functional architecture for Cognitive AI that serves as a roadmap for AI systems that can perform complex multi-step knowledge work. We propose that Cognitive AI is a necessary precursor for the evolution of higher forms of AI, such as AGI, and specifically claim that AGI cannot be achieved by probabilistic approaches on their own. We conclude with a discussion of the implications for large language models, adoption cycles in AI, and commercial Cognitive AI development.

Development of multimodal interactive systems is hindered by the lack of rich, multimodal (text, images) conversational data, which is needed in large quantities for LLMs. Previous approaches augment textual dialogues with retrieved images, posing privacy, diversity, and quality constraints. In this work, we introduce \textbf{M}ultimodal \textbf{A}ugmented \textbf{G}enerative \textbf{I}mages \textbf{D}ialogues (MAGID), a framework to augment text-only dialogues with diverse and high-quality images. Subsequently, a diffusion model is applied to craft corresponding images, ensuring alignment with the identified text. Finally, MAGID incorporates an innovative feedback loop between an image description generation module (textual LLM) and image quality modules (addressing aesthetics, image-text matching, and safety), that work in tandem to generate high-quality and multi-modal dialogues. We compare MAGID to other SOTA baselines on three dialogue datasets, using automated and human evaluation. Our results show that MAGID is comparable to or better than baselines, with significant improvements in human evaluation, especially against retrieval baselines where the image database is small.