High-throughput phenotyping automates the mapping of patient signs to standardized ontology concepts and is essential for precision medicine. This study evaluates the automation of phenotyping of clinical summaries from the Online Mendelian Inheritance in Man (OMIM) database using large language models. Due to their rich phenotype data, these summaries can be surrogates for physician notes. We conduct a performance comparison of GPT-4 and GPT-3.5-Turbo. Our results indicate that GPT-4 surpasses GPT-3.5-Turbo in identifying, categorizing, and normalizing signs, achieving concordance with manual annotators comparable to inter-rater agreement. Despite some limitations in sign normalization, the extensive pre-training of GPT-4 results in high performance and generalizability across several phenotyping tasks while obviating the need for manually annotated training data. Large language models are expected to be the dominant method for automating high-throughput phenotyping of clinical text.

Large language models (LLMs) are trained on a deluge of text data with limited quality control. As a result, LLMs can exhibit unintended or even harmful behaviours, such as leaking information, fake news or hate speech. Countermeasures, commonly referred to as preference alignment, include fine-tuning the pretrained LLMs with carefully crafted text examples of desired behaviour. Even then, empirical evidence shows preference aligned LLMs can be enticed to harmful behaviour. This so called jailbreaking of LLMs is typically achieved by adversarially modifying the input prompt to the LLM. Our paper provides theoretical insights into the phenomenon of preference alignment and jailbreaking from a statistical perspective. Under our framework, we first show that pretrained LLMs will mimic harmful behaviour if present in the training corpus. Under that same framework, we then introduce a statistical notion of alignment, and lower-bound the jailbreaking probability, showing that it is unpreventable under reasonable assumptions. Based on our insights, we propose an alteration to the currently prevalent alignment strategy RLHF. Specifically, we introduce a simple modification to the RLHF objective, we call E-RLHF, that aims to increase the likelihood of safe responses. E-RLHF brings no additional training cost, and is compatible with other methods. Empirically, we demonstrate that E-RLHF outperforms RLHF on all alignment problems put forward by the AdvBench and HarmBench project without sacrificing model performance as measured by the MT-Bench project.

Large Language Models (LLMs) have made significant advances in natural language processing, but their underlying mechanisms are often misunderstood. Despite exhibiting coherent answers and apparent reasoning behaviors, LLMs rely on statistical patterns in word embeddings rather than true cognitive processes. This leads to vulnerabilities such as "hallucination" and misinformation. The paper argues that current LLM architectures are inherently untrustworthy due to their reliance on correlations of sequential patterns of word embedding vectors. However, ongoing research into combining generative transformer-based models with fact bases and logic programming languages may lead to the development of trustworthy LLMs capable of generating statements based on given truth and explaining their self-reasoning process.

In recent years, Large Language Models (LLMs) have demonstrated remarkable capabilities across a wide range of natural language processing (NLP) tasks, such as question-answering, sentiment analysis, text summarization, and machine translation. However, the ever-growing complexity of LLMs demands immense computational resources, hindering the broader research and application of these models. To address this, various parameter-efficient fine-tuning strategies, such as Low-Rank Approximation (LoRA) and Adapters, have been developed. Despite their potential, these methods often face limitations in compressibility. Specifically, LoRA struggles to scale effectively with the increasing number of trainable parameters in modern large scale LLMs. Additionally, Low-Rank Economic Tensor-Train Adaptation (LoRETTA), which utilizes tensor train decomposition, has not yet achieved the level of compression necessary for fine-tuning very large scale models with limited resources. This paper introduces Tensor Train Low-Rank Approximation (TT-LoRA), a novel parameter-efficient fine-tuning (PEFT) approach that extends LoRETTA with optimized tensor train (TT) decomposition integration. By eliminating Adapters and traditional LoRA-based structures, TT-LoRA achieves greater model compression without compromising downstream task performance, along with reduced inference latency and computational overhead. We conduct an exhaustive parameter search to establish benchmarks that highlight the trade-off between model compression and performance. Our results demonstrate significant compression of LLMs while maintaining comparable performance to larger models, facilitating their deployment on resource-constraint platforms.

Large Language Models are expressive tools that enable complex tasks of text understanding within Computational Social Science. Their versatility, while beneficial, poses a barrier for establishing standardized best practices within the field. To bring clarity on the values of different strategies, we present an overview of the performance of modern LLM-based classification methods on a benchmark of 23 social knowledge tasks. Our results point to three best practices: select models with larger vocabulary and pre-training corpora; avoid simple zero-shot in favor of AI-enhanced prompting; fine-tune on task-specific data, and consider more complex forms instruction-tuning on multiple datasets only when only training data is more abundant.

The emergence of Large Language Models (LLMs) have fundamentally altered the way we interact with digital systems and have led to the pursuit of LLM powered AI agents to assist in daily workflows. LLMs, whilst powerful and capable of demonstrating some emergent properties, are not logical reasoners and often struggle to perform well at all sub-tasks carried out by an AI agent to plan and execute a workflow. While existing studies tackle this lack of proficiency by generalised pretraining at a huge scale or by specialised fine-tuning for tool use, we assess if a system comprising of a coalition of pretrained LLMs, each exhibiting specialised performance at individual sub-tasks, can match the performance of single model agents. The coalition of models approach showcases its potential for building robustness and reducing the operational costs of these AI agents by leveraging traits exhibited by specific models. Our findings demonstrate that fine-tuning can be mitigated by considering a coalition of pretrained models and believe that this approach can be applied to other non-agentic systems which utilise LLMs.

Unanticipated runtime errors, lacking predefined handlers, can abruptly terminate execution and lead to severe consequences, such as data loss or system crashes. Despite extensive efforts to identify potential errors during the development phase, such unanticipated errors remain a challenge to to be entirely eliminated, making the runtime mitigation measurements still indispensable to minimize their impact. Automated self-healing techniques, such as reusing existing handlers, have been investigated to reduce the loss coming through with the execution termination. However, the usability of existing methods is retained by their predefined heuristic rules and they fail to handle diverse runtime errors adaptively. Recently, the advent of Large Language Models (LLMs) has opened new avenues for addressing this problem. Inspired by their remarkable capabilities in understanding and generating code, we propose to deal with the runtime errors in a real-time manner using LLMs. Specifically, we propose Healer, the first LLM-assisted self-healing framework for handling runtime errors. When an unhandled runtime error occurs, Healer will be activated to generate a piece of error-handling code with the help of its internal LLM and the code will be executed inside the runtime environment owned by the framework to obtain a rectified program state from which the program should continue its execution. Our exploratory study evaluates the performance of Healer using four different code benchmarks and three state-of-the-art LLMs, GPT-3.5, GPT-4, and CodeQwen-7B. Results show that, without the need for any fine-tuning, GPT-4 can successfully help programs recover from 72.8% of runtime errors, highlighting the potential of LLMs in handling runtime errors.

This study investigates the effectiveness of Large Language Models (LLMs) in interpreting existing literature through a systematic review of the relationship between Environmental, Social, and Governance (ESG) factors and financial performance. The primary objective is to assess how LLMs can replicate a systematic review on a corpus of ESG-focused papers. We compiled and hand-coded a database of 88 relevant papers published from March 2020 to May 2024. Additionally, we used a set of 238 papers from a previous systematic review of ESG literature from January 2015 to February 2020. We evaluated two current state-of-the-art LLMs, Meta AI's Llama 3 8B and OpenAI's GPT-4o, on the accuracy of their interpretations relative to human-made classifications on both sets of papers. We then compared these results to a "Custom GPT" and a fine-tuned GPT-4o Mini model using the corpus of 238 papers as training data. The fine-tuned GPT-4o Mini model outperformed the base LLMs by 28.3% on average in overall accuracy on prompt 1. At the same time, the "Custom GPT" showed a 3.0% and 15.7% improvement on average in overall accuracy on prompts 2 and 3, respectively. Our findings reveal promising results for investors and agencies to leverage LLMs to summarize complex evidence related to ESG investing, thereby enabling quicker decision-making and a more efficient market.

In this work, we introduce Gemma 2, a new addition to the Gemma family of lightweight, state-of-the-art open models, ranging in scale from 2 billion to 27 billion parameters. In this new version, we apply several known technical modifications to the Transformer architecture, such as interleaving local-global attentions (Beltagy et al., 2020a) and group-query attention (Ainslie et al., 2023). We also train the 2B and 9B models with knowledge distillation (Hinton et al., 2015) instead of next token prediction. The resulting models deliver the best performance for their size, and even offer competitive alternatives to models that are 2-3 times bigger. We release all our models to the community.

This paper describes IAI group's participation for automated check-worthiness estimation for claims, within the framework of the 2024 CheckThat! Lab "Task 1: Check-Worthiness Estimation". The task involves the automated detection of check-worthy claims in English, Dutch, and Arabic political debates and Twitter data. We utilized various pre-trained generative decoder and encoder transformer models, employing methods such as few-shot chain-of-thought reasoning, fine-tuning, data augmentation, and transfer learning from one language to another. Despite variable success in terms of performance, our models achieved notable placements on the organizer's leaderboard: ninth-best in English, third-best in Dutch, and the top placement in Arabic, utilizing multilingual datasets for enhancing the generalizability of check-worthiness detection. Despite a significant drop in performance on the unlabeled test dataset compared to the development test dataset, our findings contribute to the ongoing efforts in claim detection research, highlighting the challenges and potential of language-specific adaptations in claim verification systems.