Med42-v2 introduces a suite of clinical large language models (LLMs) designed to address the limitations of generic models in healthcare settings. These models are built on Llama3 architecture and fine-tuned using specialized clinical data. They underwent multi-stage preference alignment to effectively respond to natural prompts. While generic models are often preference-aligned to avoid answering clinical queries as a precaution, Med42-v2 is specifically trained to overcome this limitation, enabling its use in clinical settings. Med42-v2 models demonstrate superior performance compared to the original Llama3 models in both 8B and 70B parameter configurations and GPT-4 across various medical benchmarks. These LLMs are developed to understand clinical queries, perform reasoning tasks, and provide valuable assistance in clinical environments. The models are now publicly available at \href{https://huggingface.co/m42-health}{https://huggingface.co/m42-health}.

Recent surge in Large Language Model (LLM) availability has opened exciting avenues for research. However, efficiently interacting with these models presents a significant hurdle since LLMs often reside on proprietary or self-hosted API endpoints, each requiring custom code for interaction. Conducting comparative studies between different models can therefore be time-consuming and necessitate significant engineering effort, hindering research efficiency and reproducibility. To address these challenges, we present prompto, an open source Python library which facilitates asynchronous querying of LLM endpoints enabling researchers to interact with multiple LLMs concurrently, while maximising efficiency and utilising individual rate limits. Our library empowers researchers and developers to interact with LLMs more effectively and enabling faster experimentation and evaluation. prompto is released with an introductory video (https://youtu.be/-eZAmlV4ypk) under MIT License and is available via GitHub (https://github.com/alan-turing-institute/prompto).

In recent years, the field of radiology has increasingly harnessed the power of artificial intelligence (AI) to enhance diagnostic accuracy, streamline workflows, and improve patient care. Large language models (LLMs) have emerged as particularly promising tools, offering significant potential in assisting radiologists with report generation, clinical decision support, and patient communication. This paper presents an advanced radiology-focused large language model: MGH Radiology Llama. It is developed using the Llama 3 70B model, building upon previous domain-specific models like Radiology-GPT and Radiology-Llama2. Leveraging a unique and comprehensive dataset from Massachusetts General Hospital, comprising over 6.5 million de-identified medical reports across various imaging modalities, the model demonstrates significant improvements in generating accurate and clinically relevant radiology impressions given the corresponding findings. Our evaluation, incorporating both traditional metrics and a GPT-4-based assessment, highlights the enhanced performance of this work over general-purpose LLMs.

Retrieval Augmented Generation (RAG) is a technique commonly used to equip models with out of distribution knowledge. This process involves collecting, indexing, retrieving, and providing information to an LLM for generating responses. Despite its growing popularity due to its flexibility and low cost, the security implications of RAG have not been extensively studied. The data for such systems are often collected from public sources, providing an attacker a gateway for indirect prompt injections to manipulate the responses of the model. In this paper, we investigate the security of RAG systems against end-to-end indirect prompt manipulations. First, we review existing RAG framework pipelines, deriving a prototypical architecture and identifying critical parameters. We then examine prior works searching for techniques that attackers can use to perform indirect prompt manipulations. Finally, we implemented Rag 'n Roll, a framework to determine the effectiveness of attacks against end-to-end RAG applications. Our results show that existing attacks are mostly optimized to boost the ranking of malicious documents during the retrieval phase. However, a higher rank does not immediately translate into a reliable attack. Most attacks, against various configurations, settle around a 40% success rate, which could rise to 60% when considering ambiguous answers as successful attacks (those that include the expected benign one as well). Additionally, when using unoptimized documents, attackers deploying two of them (or more) for a target query can achieve similar results as those using optimized ones. Finally, exploration of the configuration space of a RAG showed limited impact in thwarting the attacks, where the most successful combination severely undermines functionality.

Medical dialogue systems (MDS) enhance patient-physician communication, improve healthcare accessibility, and reduce costs. However, acquiring suitable data to train these systems poses significant challenges. Privacy concerns prevent the use of real conversations, necessitating synthetic alternatives. Synthetic dialogue generation from publicly available clinical notes offers a promising solution to this issue, providing realistic data while safeguarding privacy. Our approach, SynDial, uses a single LLM iteratively with zero-shot prompting and a feedback loop to generate and refine high-quality synthetic dialogues. The feedback consists of weighted evaluation scores for similarity and extractiveness. The iterative process ensures dialogues meet predefined thresholds, achieving superior extractiveness as a result of the feedback loop. Additionally, evaluation shows that the generated dialogues excel in factuality metric compared to the baselines and has comparable diversity scores with GPT4.

We propose a novel in-context learning algorithm for building autonomous decision-making language agents. The language agent continuously attempts to solve the same task by self-correcting each time the task fails. Our selected language agent demonstrates the ability to solve tasks in a text-based game environment. Our results show that the gemma-2-9b-it language model, using our proposed method, can successfully complete two of six tasks that failed in the first attempt. This highlights the effectiveness of our approach in enhancing the problem-solving capabilities of a single language model through self-correction, paving the way for more advanced autonomous agents. The code is publicly available at https://github.com/YenCheHsiao/AutonomousLLMAgentwithAdaptingPlanning.

Large language models (LLMs) have brought autonomous agents closer to artificial general intelligence (AGI) due to their promising generalization and emergent capabilities. There is, however, a lack of studies on how LLM-based agents behave, why they could potentially fail, and how to improve them, particularly in demanding real-world planning tasks. In this paper, as an effort to fill the gap, we present our study using a realistic benchmark, TravelPlanner, where an agent must meet multiple constraints to generate accurate plans. We leverage this benchmark to address four key research questions: (1) are LLM agents robust enough to lengthy and noisy contexts when it comes to reasoning and planning? (2) can few-shot prompting adversely impact the performance of LLM agents in scenarios with long context? (3) can we rely on refinement to improve plans, and (4) can fine-tuning LLMs with both positive and negative feedback lead to further improvement? Our comprehensive experiments indicate that, firstly, LLMs often fail to attend to crucial parts of a long context, despite their ability to handle extensive reference information and few-shot examples; secondly, they still struggle with analyzing the long plans and cannot provide accurate feedback for refinement; thirdly, we propose Feedback-Aware Fine-Tuning (FAFT), which leverages both positive and negative feedback, resulting in substantial gains over Supervised Fine-Tuning (SFT). Our findings offer in-depth insights to the community on various aspects related to real-world planning applications.

Tables are crucial containers of information, but understanding their meaning may be challenging. Indeed, recently, there has been a focus on Semantic Table Interpretation (STI), i.e., the task that involves the semantic annotation of tabular data to disambiguate their meaning. Over the years, there has been a surge in interest in data-driven approaches based on deep learning that have increasingly been combined with heuristic-based approaches. In the last period, the advent of Large Language Models (LLMs) has led to a new category of approaches for table annotation. The interest in this research field, characterised by multiple challenges, has led to a proliferation of approaches employing different techniques. However, these approaches have not been consistently evaluated on a common ground, making evaluation and comparison difficult. This work proposes an extensive evaluation of four state-of-the-art (SOTA) approaches - Alligator (formerly s-elBat), Dagobah, TURL, and TableLlama; the first two belong to the family of heuristic-based algorithms, while the others are respectively encoder-only and decoder-only LLMs. The primary objective is to measure the ability of these approaches to solve the entity disambiguation task, with the ultimate aim of charting new research paths in the field.

This research addresses the issue of missing structured data in dental records by extracting diagnostic information from unstructured text. The updated periodontology classification system's complexity has increased incomplete or missing structured diagnoses. To tackle this, we use advanced AI and NLP methods, leveraging GPT-4 to generate synthetic notes for fine-tuning a RoBERTa model. This significantly enhances the model's ability to understand medical and dental language. We evaluated the model using 120 randomly selected clinical notes from two datasets, demonstrating its improved diagnostic extraction accuracy. The results showed high accuracy in diagnosing periodontal status, stage, and grade, with Site 1 scoring 0.99 and Site 2 scoring 0.98. In the subtype category, Site 2 achieved perfect scores, outperforming Site 1. This method enhances extraction accuracy and broadens its use across dental contexts. The study underscores AI and NLP's transformative impact on healthcare delivery and management. Integrating AI and NLP technologies enhances documentation and simplifies administrative tasks by precisely extracting complex clinical information. This approach effectively addresses challenges in dental diagnostics. Using synthetic training data from LLMs optimizes the training process, improving accuracy and efficiency in identifying periodontal diagnoses from clinical notes. This innovative method holds promise for broader healthcare applications, potentially improving patient care quality.

The rapid advancement of Large Language Models (LLMs) and conversational assistants necessitates dynamic, scalable, and configurable conversational datasets for training and evaluation. These datasets must accommodate diverse user interaction modes, including text and voice, each presenting unique modeling challenges. Knowledge Graphs (KGs), with their structured and evolving nature, offer an ideal foundation for current and precise knowledge. Although human-curated KG-based conversational datasets exist, they struggle to keep pace with the rapidly changing user information needs. We present ConvKGYarn, a scalable method for generating up-to-date and configurable conversational KGQA datasets. Qualitative psychometric analyses confirm our method can generate high-quality datasets rivaling a popular conversational KGQA dataset while offering it at scale and covering a wide range of human-interaction configurations. We showcase its utility by testing LLMs on diverse conversations - exploring model behavior on conversational KGQA sets with different configurations grounded in the same KG fact set. Our results highlight the ability of ConvKGYarn to improve KGQA foundations and evaluate parametric knowledge of LLMs, thus offering a robust solution to the constantly evolving landscape of conversational assistants.