Large language models (LLMs) have shown potential in biomedical applications, leading to efforts to fine-tune them on domain-specific data. However, the effectiveness of this approach remains unclear. This study evaluates the performance of biomedically fine-tuned LLMs against their general-purpose counterparts on a variety of clinical tasks. We evaluated their performance on clinical case challenges from the New England Journal of Medicine (NEJM) and the Journal of the American Medical Association (JAMA) and on several clinical tasks (e.g., information extraction, document summarization, and clinical coding). Using benchmarks specifically chosen to be likely outside the fine-tuning datasets of biomedical models, we found that biomedical LLMs mostly perform inferior to their general-purpose counterparts, especially on tasks not focused on medical knowledge. While larger models showed similar performance on case tasks (e.g., OpenBioLLM-70B: 66.4% vs. Llama-3-70B-Instruct: 65% on JAMA cases), smaller biomedical models showed more pronounced underperformance (e.g., OpenBioLLM-8B: 30% vs. Llama-3-8B-Instruct: 64.3% on NEJM cases). Similar trends were observed across the CLUE (Clinical Language Understanding Evaluation) benchmark tasks, with general-purpose models often performing better on text generation, question answering, and coding tasks. Our results suggest that fine-tuning LLMs to biomedical data may not provide the expected benefits and may potentially lead to reduced performance, challenging prevailing assumptions about domain-specific adaptation of LLMs and highlighting the need for more rigorous evaluation frameworks in healthcare AI. Alternative approaches, such as retrieval-augmented generation, may be more effective in enhancing the biomedical capabilities of LLMs without compromising their general knowledge.

Zero-shot graph machine learning, especially with graph neural networks (GNNs), has garnered significant interest due to the challenge of scarce labeled data. While methods like self-supervised learning and graph prompt learning have been extensively explored, they often rely on fine-tuning with task-specific labels, limiting their effectiveness in zero-shot scenarios. Inspired by the zero-shot capabilities of instruction-fine-tuned large language models (LLMs), we introduce a novel framework named Token Embedding-Aligned Graph Language Model (TEA-GLM) that leverages LLMs as cross-dataset and cross-task zero-shot learners for graph machine learning. Concretely, we pretrain a GNN, aligning its representations with token embeddings of an LLM. We then train a linear projector that transforms the GNN's representations into a fixed number of graph token embeddings without tuning the LLM. A unified instruction is designed for various graph tasks at different levels, such as node classification (node-level) and link prediction (edge-level). These design choices collectively enhance our method's effectiveness in zero-shot learning, setting it apart from existing methods. Experiments show that our graph token embeddings help the LLM predictor achieve state-of-the-art performance on unseen datasets and tasks compared to other methods using LLMs as predictors.

Large language models (LLMs) create a new paradigm for natural language processing. Despite their advancement, LLM-based methods still lag behind traditional approaches in document-level relation extraction (DocRE), a critical task for understanding complex entity relations. This paper investigates the causes of this performance gap, identifying the dispersion of attention by LLMs due to entity pairs without relations as a primary factor. We then introduce a novel classifier-LLM approach to DocRE. The proposed approach begins with a classifier specifically designed to select entity pair candidates exhibiting potential relations and thereby feeds them to LLM for the final relation extraction. This method ensures that during inference, the LLM's focus is directed primarily at entity pairs with relations. Experiments on DocRE benchmarks reveal that our method significantly outperforms recent LLM-based DocRE models and achieves competitive performance with several leading traditional DocRE models.

With the increasing popularity of large language models (LLMs), reasoning on basic graph algorithm problems is an essential intermediate step in assessing their abilities to process and infer complex graph reasoning tasks. Existing methods usually convert graph-structured data to textual descriptions and then use LLMs for reasoning and computation. However, LLMs often produce computation errors on arithmetic parts in basic graph algorithm problems, such as counting number of edges. In addition, they struggle to control or understand the output of the reasoning process, raising concerns about whether LLMs are simply guessing. In this paper, we introduce CodeGraph, a method that encodes graph problem solutions as code. The methods solve new graph problems by learning from exemplars, generating programs, and executing them via a program interpreter. Using the few-shot setting, we evaluate CodeGraph with the base LLM being GPT-3.5 Turbo, Llama3-70B Instruct, Mixtral-8x22B Instruct, and Mixtral-8x7B Instruct. Experimental results on six tasks with six graph encoding methods in the GraphQA dataset demonstrate that CodeGraph can boost performance on graph reasoning tasks inside LLMs by 1.3% to 58.6%, depending on the task. Compared to the existing methods, CodeGraph demonstrates strong performance on arithmetic problems in graph tasks and offers a more controllable and interpretable approach to the reasoning process.

The guidance from capability evaluations has greatly propelled the progress of both human society and Artificial Intelligence. However, as LLMs evolve, it becomes challenging to construct evaluation benchmarks for them with accurate labels on hard tasks that approach the boundaries of human capabilities. To credibly conduct evaluation without accurate labels (denoted as poor-supervised evaluation), we propose the PoEM framework. We first prove that the capability of a model can be equivalently assessed by the consistency between it and certain reference model, when their prediction distributions are independent and the sample size is infinite. To alleviate the insufficiencies of the conditions in reality, we further introduce an algorithm that treats humans (when available) and the models under evaluation as reference models, alternately conducting model weights calibration and filtering during E-step and M-step. Comprehensive experiments across 3 types of tasks with 16 mainstream LLMs have shown that PoEM under poor supervision can achieve an average of 0.98 Pearson correlation coefficient with supervised evaluation results, demonstrating good effectiveness, efficiency and generalizability. More generally, PoEM has advanced the evaluation paradigm evolution from human-centric to human&model-centric by treating both of them as reference models, mitigating the limitations of human evaluation in the era of LLMs.

Recent advances in text-to-image diffusion models have demonstrated impressive capabilities in image quality. However, complex scene generation remains relatively unexplored, and even the definition of `complex scene' itself remains unclear. In this paper, we address this gap by providing a precise definition of complex scenes and introducing a set of Complex Decomposition Criteria (CDC) based on this definition. Inspired by the artists painting process, we propose a training-free diffusion framework called Complex Diffusion (CxD), which divides the process into three stages: composition, painting, and retouching. Our method leverages the powerful chain-of-thought capabilities of large language models (LLMs) to decompose complex prompts based on CDC and to manage composition and layout. We then develop an attention modulation method that guides simple prompts to specific regions to complete the complex scene painting. Finally, we inject the detailed output of the LLM into a retouching model to enhance the image details, thus implementing the retouching stage. Extensive experiments demonstrate that our method outperforms previous SOTA approaches, significantly improving the generation of high-quality, semantically consistent, and visually diverse images for complex scenes, even with intricate prompts.

Human mobility prediction plays a crucial role in various real-world applications. Although deep learning based models have shown promising results over the past decade, their reliance on extensive private mobility data for training and their inability to perform zero-shot predictions, have hindered further advancements. Recently, attempts have been made to apply large language models (LLMs) to mobility prediction task. However, their performance has been constrained by the absence of a systematic design of workflow. They directly generate the final output using LLMs, which limits the potential of LLMs to uncover complex mobility patterns and underestimates their extensive reserve of global geospatial knowledge. In this paper, we introduce AgentMove, a systematic agentic prediction framework to achieve generalized mobility prediction for any cities worldwide. In AgentMove, we first decompose the mobility prediction task into three sub-tasks and then design corresponding modules to complete these subtasks, including spatial-temporal memory for individual mobility pattern mining, world knowledge generator for modeling the effects of urban structure and collective knowledge extractor for capturing the shared patterns among population. Finally, we combine the results of three modules and conduct a reasoning step to generate the final predictions. Extensive experiments on mobility data from two sources in 12 cities demonstrate that AgentMove outperforms the best baseline more than 8% in various metrics and it shows robust predictions with various LLMs as base and also less geographical bias across cities. Codes and data can be found in https://github.com/tsinghua-fib-lab/AgentMove.

The rapid advancement of large language models (LLMs) has significantly impacted various domains, including healthcare and biomedicine. However, the phenomenon of hallucination, where LLMs generate outputs that deviate from factual accuracy or context, poses a critical challenge, especially in high-stakes domains. This paper conducts a scoping study of existing techniques for mitigating hallucinations in knowledge-based task in general and especially for medical domains. Key methods covered in the paper include Retrieval-Augmented Generation (RAG)-based techniques, iterative feedback loops, supervised fine-tuning, and prompt engineering. These techniques, while promising in general contexts, require further adaptation and optimization for the medical domain due to its unique demands for up-to-date, specialized knowledge and strict adherence to medical guidelines. Addressing these challenges is crucial for developing trustworthy AI systems that enhance clinical decision-making and patient safety as well as accuracy of biomedical scientific research.

Underwater communication is essential for environmental monitoring, marine biology research, and underwater exploration. Traditional underwater communication faces limitations like low bandwidth, high latency, and susceptibility to noise, while semantic communication (SC) offers a promising solution by focusing on the exchange of semantics rather than symbols or bits. However, SC encounters challenges in underwater environments, including semantic information mismatch and difficulties in accurately identifying and transmitting critical information that aligns with the diverse requirements of underwater applications. To address these challenges, we propose a novel Semantic Communication (SC) framework based on Large Language Models (LLMs). Our framework leverages visual LLMs to perform semantic compression and prioritization of underwater image data according to the query from users. By identifying and encoding key semantic elements within the images, the system selectively transmits high-priority information while applying higher compression rates to less critical regions. On the receiver side, an LLM-based recovery mechanism, along with Global Vision ControlNet and Key Region ControlNet networks, aids in reconstructing the images, thereby enhancing communication efficiency and robustness. Our framework reduces the overall data size to 0.8\% of the original. Experimental results demonstrate that our method significantly outperforms existing approaches, ensuring high-quality, semantically accurate image reconstruction.

Large language models (LLMs) have revolutionized language processing, delivering outstanding results across multiple applications. However, deploying LLMs on edge devices poses several challenges with respect to memory, energy, and compute costs, limiting their widespread use in devices such as mobile phones. A promising solution is to reduce the number of bits used to represent weights and activations. While existing works have found partial success at quantizing LLMs to lower bitwidths, e.g. 4-bit weights, quantizing activations beyond 16 bits often leads to large computational overheads due to poor on-device quantization support, or a considerable accuracy drop. Yet, 8-bit activations are very attractive for on-device deployment as they would enable LLMs to fully exploit mobile-friendly hardware, e.g. Neural Processing Units (NPUs). In this work, we make a first attempt to facilitate the on-device deployment of LLMs using integer-only quantization. We first investigate the limitations of existing quantization methods for on-device deployment, with a special focus on activation quantization. We then address these limitations by introducing a simple post-training quantization method, named MobileQuant, that extends previous weight equivalent transformation works by jointly optimizing the weight transformation and activation range parameters in an end-to-end manner. MobileQuant demonstrates superior capabilities over existing methods by 1) achieving near-lossless quantization on a wide range of LLM benchmarks, 2) reducing latency and energy consumption by 20\%-50\% compared to current on-device quantization strategies, 3) requiring limited compute budget, 4) being compatible with mobile-friendly compute units, e.g. NPU.