The scarcity of subspecialist medical expertise, particularly in rare, complex and life-threatening diseases, poses a significant challenge for healthcare delivery. This issue is particularly acute in cardiology where timely, accurate management determines outcomes. We explored the potential of AMIE (Articulate Medical Intelligence Explorer), a large language model (LLM)-based experimental AI system optimized for diagnostic dialogue, to potentially augment and support clinical decision-making in this challenging context. We curated a real-world dataset of 204 complex cases from a subspecialist cardiology practice, including results for electrocardiograms, echocardiograms, cardiac MRI, genetic tests, and cardiopulmonary stress tests. We developed a ten-domain evaluation rubric used by subspecialists to evaluate the quality of diagnosis and clinical management plans produced by general cardiologists or AMIE, the latter enhanced with web-search and self-critique capabilities. AMIE was rated superior to general cardiologists for 5 of the 10 domains (with preference ranging from 9% to 20%), and equivalent for the rest. Access to AMIE's response improved cardiologists' overall response quality in 63.7% of cases while lowering quality in just 3.4%. Cardiologists' responses with access to AMIE were superior to cardiologist responses without access to AMIE for all 10 domains. Qualitative examinations suggest AMIE and general cardiologist could complement each other, with AMIE thorough and sensitive, while general cardiologist concise and specific. Overall, our results suggest that specialized medical LLMs have the potential to augment general cardiologists' capabilities by bridging gaps in subspecialty expertise, though further research and validation are essential for wide clinical utility.

Gene expression is a cellular process that plays a fundamental role in human phenotypical variations and diseases. Despite advances of deep learning models for gene expression prediction, recent benchmarks have revealed their inability to learn distal regulatory grammar. Here, we address this challenge by leveraging a pretrained large language model to enhance gene expression prediction. We introduce Genetic sequence Token Alignment (GTA), which aligns genetic sequence features with natural language tokens, allowing for symbolic reasoning of genomic sequence features via the frozen language model. This cross-modal adaptation learns the regulatory grammar and allows us to further incorporate gene-specific human annotations as prompts, enabling in-context learning that is not possible with existing models. Trained on lymphoblastoid cells, GTA was evaluated on cells from the Geuvadis consortium and outperforms state-of-the-art models such as Enformer, achieving a Spearman correlation of 0.65, a 10\% improvement. Additionally, GTA offers improved interpretation of long-range interactions through the identification of the most meaningful sections of the input genetic context. GTA represents a powerful and novel cross-modal approach to gene expression prediction by utilizing a pretrained language model, in a paradigm shift from conventional gene expression models trained only on sequence data.

While Large Language Models (LLMs) demonstrate impressive generation abilities, they frequently struggle when it comes to specialized domains due to their limited domain-specific knowledge. Studies on domain-specific LLMs resort to expanding the vocabulary before fine-tuning on domain-specific corpus, aiming to decrease the sequence length and enhance efficiency during decoding, without thoroughly investigating the results of vocabulary expansion to LLMs over different domains. Our pilot study reveals that expansion with only a subset of the entire vocabulary may lead to superior performance. Guided by the discovery, this paper explores how to identify a vocabulary subset to achieve the optimal results. We introduce VEGAD, an adaptive method that automatically identifies valuable words from a given domain vocabulary. Our method has been validated through experiments on three Chinese datasets, demonstrating its effectiveness. Additionally, we have undertaken comprehensive analyses of the method. The selection of a optimal subset for expansion has shown to enhance performance on both domain-specific tasks and general tasks, showcasing the potential of VEGAD.

We present FastLexRank\footnote{https://github.com/LiMaoUM/FastLexRank}, an efficient and scalable implementation of the LexRank algorithm for text ranking. Designed to address the computational and memory complexities of the original LexRank method, FastLexRank significantly reduces time and memory requirements from $\mathcal{O}(n^2)$ to $\mathcal{O}(n)$ without compromising the quality or accuracy of the results. By employing an optimized approach to calculating the stationary distribution of sentence graphs, FastLexRank maintains an identical results with the original LexRank scores while enhancing computational efficiency. This paper details the algorithmic improvements that enable the processing of large datasets, such as social media corpora, in real-time. Empirical results demonstrate its effectiveness, and we propose its use in identifying central tweets, which can be further analyzed using advanced NLP techniques. FastLexRank offers a scalable solution for text centrality calculation, addressing the growing need for efficient processing of digital content.

Localizing unusual activities, such as human errors or surveillance incidents, in videos holds practical significance. However, current video understanding models struggle with localizing these unusual events likely because of their insufficient representation in models' pretraining datasets. To explore foundation models' capability in localizing unusual activity, we introduce UAL-Bench, a comprehensive benchmark for unusual activity localization, featuring three video datasets: UAG-OOPS, UAG-SSBD, UAG-FunQA, and an instruction-tune dataset: OOPS-UAG-Instruct, to improve model capabilities. UAL-Bench evaluates three approaches: Video-Language Models (Vid-LLMs), instruction-tuned Vid-LLMs, and a novel integration of Vision-Language Models and Large Language Models (VLM-LLM). Our results show the VLM-LLM approach excels in localizing short-span unusual events and predicting their onset (start time) more accurately than Vid-LLMs. We also propose a new metric, R@1, TD <= p, to address limitations in existing evaluation methods. Our findings highlight the challenges posed by long-duration videos, particularly in autism diagnosis scenarios, and the need for further advancements in localization techniques. Our work not only provides a benchmark for unusual activity localization but also outlines the key challenges for existing foundation models, suggesting future research directions on this important task.

While large language models (LLMs) have seen unprecedented advancements in capabilities and applications across a variety of use-cases, safety alignment of these models is still an area of active research. The fragile nature of LLMs, even models that have undergone extensive alignment and safety training regimes, warrants additional safety steering steps via training-free, inference-time methods. While recent work in the area of mechanistic interpretability has investigated how activations in latent representation spaces may encode concepts, and thereafter performed representation engineering to induce such concepts in LLM outputs, the applicability of such for safety is relatively under-explored. Unlike recent inferencetime safety steering works, in this paper we explore safety steering of LLM outputs using: (i) category-specific steering vectors, thereby enabling fine-grained control over the steering, and (ii) sophisticated methods for extracting informative steering vectors for more effective safety steering while retaining quality of the generated text. We demonstrate our exploration on multiple LLMs and datasets, and showcase the effectiveness of the proposed steering method, along with a discussion on the implications and best practices. Content Warning: This paper contains examples of harmful language.

Large language models excel at creative generation but continue to struggle with the issues of hallucination and bias. While retrieval-augmented generation (RAG) provides a framework for grounding LLMs' responses in accurate and up-to-date information, it still raises the question of bias: which sources should be selected for inclusion in the context? And how should their importance be weighted? In this paper, we study the challenge of cross-lingual RAG and present a dataset to investigate the robustness of existing systems at answering queries about geopolitical disputes, which exist at the intersection of linguistic, cultural, and political boundaries. Our dataset is sourced from Wikipedia pages containing information relevant to the given queries and we investigate the impact of including additional context, as well as the composition of this context in terms of language and source, on an LLM's response. Our results show that existing RAG systems continue to be challenged by cross-lingual use cases and suffer from a lack of consistency when they are provided with competing information in multiple languages. We present case studies to illustrate these issues and outline steps for future research to address these challenges. We make our dataset and code publicly available at https://github.com/manestay/bordIRlines.

As speech becomes an increasingly common modality for interacting with large language models (LLMs), it is becoming desirable to develop systems where LLMs can take into account users' emotions or speaking styles when providing their responses. In this work, we study the potential of an LLM to understand these aspects of speech without fine-tuning its weights. To do this, we utilize an end-to-end system with a speech encoder; the encoder is trained to produce token embeddings such that the LLM's response to an expressive speech prompt is aligned with its response to a semantically matching text prompt where the speaker's emotion has also been specified. We find that this training framework allows the encoder to generate tokens that capture both semantic and paralinguistic information in speech and effectively convey it to the LLM, even when the LLM remains completely frozen. We also explore training on additional emotion and style-related response alignment tasks, finding that they further increase the amount of paralinguistic information explicitly captured in the speech tokens. Experiments demonstrate that our system is able to produce higher quality and more empathetic responses to expressive speech prompts compared to several baselines.

It is common to reject undesired outputs of Large Language Models (LLMs); however, current methods to do so require an excessive amount of computation, or severely distort the distribution of outputs. We present a method to balance the distortion of the output distribution with computational efficiency, allowing for the generation of long sequences of text with difficult-to-satisfy constraints, with less amplification of low probability outputs compared to existing methods. We show through a series of experiments that the task-specific performance of our method is comparable to methods that do not distort the output distribution, while being much more computationally efficient. Language models sometimes generate undesirable outputs, such as syntactically-incorrect code, hallucinated PII, or profanity. These conditions, which we collectively refer to as errors for the remainder of the paper, can be detected with incremental parsers, regular expression matching, or even simple substring searches. However, once detection occurs, there are several competing methods for mitigating errors in the output. One set of methods, constrained generation (Beurer-Kellner et al., 2024; Geng et al., 2024; Melcer et al., 2024), avoids errors by disabling the generation of any token that immediately leads to such an error. While this method is effective, it can lead to the amplification of low-probability outputs. Another class of methods avoids errors without any amplification of low-probability outputs, at the cost of additional computation. Rejection sampling is the simplest such method; i.e. if the output contains an error, simply generate another sample until the output is acceptable. Adaptive Sampling with Approximate Expected Futures (ASAp) (Park et al., 2024) provides a performance improvement over rejection sampling while maintaining the output distribution by effectively sampling without replacement, but there are still many situations in which it may converge too slowly. In our experiments, we show that our method obtains task-specific performance on par with ASAp, while converging significantly faster when the constraints are difficult to satisfy. We first describe autoregressive language models and their properties.

This paper investigates the transformative potential of generative AI technologies, particularly large language models (LLMs), within the building industry. By leveraging these advanced AI tools, the study explores their application across key areas such as energy code compliance, building design optimization, and workforce training. The research highlights how LLMs can automate labor-intensive processes, significantly improving efficiency, accuracy, and safety in building practices. The paper also addresses the challenges associated with interpreting complex visual and textual data in architectural plans and regulatory codes, proposing innovative solutions to enhance AI-driven compliance checking and design processes. Additionally, the study considers the broader implications of AI integration, including the development of AI-powered tools for comprehensive code compliance across various regulatory domains and the potential for AI to revolutionize workforce training through realistic simulations. This paper provides a comprehensive analysis of the current capabilities of generative AI in the building industry while outlining future directions for research and development, aiming to pave the way for smarter, more sustainable, and responsive construction practices.