Large Language Models (LLMs) have demonstrated exceptional capabilities in understanding and generating natural language. However, their high deployment costs often pose a barrier to practical applications, especially. Cascading local and server models offers a promising solution to this challenge. While existing studies on LLM cascades have primarily focused on the performance-cost tradeoff, real-world scenarios often involve more complex requirements. This paper introduces a novel LLM Cascade strategy with Multi-Objective Optimization, enabling LLM cascades to consider additional objectives (e.g., privacy) and better align with the specific demands of real-world applications while maintaining their original cascading abilities. As Large Language Models (LLMs) continue to evolve rapidly (Touvron et al., 2023; Achiam et al., 2023; Reid et al., 2024), they are increasingly being integrated into real-world applications, enhancing the intelligence of a wide range of systems. At the same time, mobile devices have become indispensable in everyday life. The emergence of on-device intelligence--such as Apple Intelligence (Gunter et al., 2024) and Gemini Live (Reid et al., 2024)--which embeds LLMs directly into devices for more personalized and intelligent user interactions, is gaining traction but remains relatively underexplored (Xu et al., 2024). A major challenge in this area is the hardware limitations of mobile devices, including constraints on compute power, battery life, and storage capacity. As a result, only smaller LLMs, such as Gemma-2B (Team et al., 2024), can be deployed on these devices, leading to trade-offs in performance compared to larger, more powerful models like Gemini.

Despite the impressive adaptability of large language models (LLMs), challenges remain in ensuring their security, transparency, and interpretability. Given their susceptibility to adversarial attacks, LLMs need to be defended with an evolving combination of adversarial training and guardrails. However, managing the implicit and heterogeneous knowledge for continuously assuring robustness is difficult. We introduce a novel approach for assurance of the adversarial robustness of LLMs based on formal argumentation. Using ontologies for formalization, we structure state-of-the-art attacks and defenses, facilitating the creation of a human-readable assurance case, and a machine-readable representation. We demonstrate its application with examples in English language and code translation tasks, and provide implications for theory and practice, by targeting engineers, data scientists, users, and auditors.

Quantum computing is an emerging field recognized for the significant speedup it offers over classical computing through quantum algorithms. However, designing and implementing quantum algorithms pose challenges due to the complex nature of quantum mechanics and the necessity for precise control over quantum states. Despite the significant advancements in AI, there has been a lack of datasets specifically tailored for this purpose. In this work, we introduce QCircuitNet, the first benchmark and test dataset designed to evaluate AI's capability in designing and implementing quantum algorithms in the form of quantum circuit codes. Unlike using AI for writing traditional codes, this task is fundamentally different and significantly more complicated due to highly flexible design space and intricate manipulation of qubits. Our key contributions include: 1. A general framework which formulates the key features of quantum algorithm design task for Large Language Models. 2. Implementation for a wide range of quantum algorithms from basic primitives to advanced applications, with easy extension to more quantum algorithms. 3. Automatic validation and verification functions, allowing for iterative evaluation and interactive reasoning without human inspection. 4. Promising potential as a training dataset through primitive fine-tuning results. We observed several interesting experimental phenomena: fine-tuning does not always outperform few-shot learning, and LLMs tend to exhibit consistent error patterns. QCircuitNet provides a comprehensive benchmark for AI-driven quantum algorithm design, offering advantages in model evaluation and improvement, while also revealing some limitations of LLMs in this domain.

The EU's Artificial Intelligence Act (AI Act) is a significant step towards responsible AI development, but lacks clear technical interpretation, making it difficult to assess models' compliance. This work presents COMPL-AI, a comprehensive framework consisting of (i) the first technical interpretation of the EU AI Act, translating its broad regulatory requirements into measurable technical requirements, with the focus on large language models (LLMs), and (ii) an open-source Act-centered benchmarking suite, based on thorough surveying and implementation of state-of-the-art LLM benchmarks. By evaluating 12 prominent LLMs in the context of COMPL-AI, we reveal shortcomings in existing models and benchmarks, particularly in areas like robustness, safety, diversity, and fairness. This work highlights the need for a shift in focus towards these aspects, encouraging balanced development of LLMs and more comprehensive regulation-aligned benchmarks. Simultaneously, COMPL-AI for the first time demonstrates the possibilities and difficulties of bringing the Act's obligations to a more concrete, technical level. As such, our work can serve as a useful first step towards having actionable recommendations for model providers, and contributes to ongoing efforts of the EU to enable application of the Act, such as the drafting of the GPAI Code of Practice.

Background: Machine learning methods for clinical named entity recognition and entity normalization systems can utilize both labeled corpora and Knowledge Graphs (KGs) for learning. However, infrequently occurring concepts may have few mentions in training corpora and lack detailed descriptions or synonyms, even in large KGs. For Disease Entity Recognition (DER) and Disease Entity Normalization (DEN), this can result in fewer high quality training examples relative to the number of known diseases. Large Language Model (LLM) generation of synthetic training examples could improve performance in these information extraction tasks. Methods: We fine-tuned a LLaMa-2 13B Chat LLM to generate a synthetic corpus containing normalized mentions of concepts from the Unified Medical Language System (UMLS) Disease Semantic Group. We measured overall and Out of Distribution (OOD) performance for DER and DEN, with and without synthetic data augmentation. We evaluated performance on 3 different disease corpora using 4 different data augmentation strategies, assessed using BioBERT for DER and SapBERT and KrissBERT for DEN. Results: Our synthetic data yielded a substantial improvement for DEN, in all 3 training corpora the top 1 accuracy of both SapBERT and KrissBERT improved by 3-9 points in overall performance and by 20-55 points in OOD data. A small improvement (1-2 points) was also seen for DER in overall performance, but only one dataset showed OOD improvement. Conclusion: LLM generation of normalized disease mentions can improve DEN relative to normalization approaches that do not utilize LLMs to augment data with synthetic mentions. Ablation studies indicate that performance gains for DEN were only partially attributable to improvements in OOD performance. The same approach has only a limited ability to improve DER. We make our software and dataset publicly available.

In sequential decision-making (SDM) tasks, methods like reinforcement learning (RL) and heuristic search have made notable advances in specific cases. However, they often require extensive exploration and face challenges in generalizing across diverse environments due to their limited grasp of the underlying decision dynamics. In contrast, large language models (LLMs) have recently emerged as powerful general-purpose tools, due to their capacity to maintain vast amounts of domainspecific knowledge. To harness this rich prior knowledge for efficiently solving complex SDM tasks, we propose treating LLMs as prior action distributions and integrating them into RL frameworks through Bayesian inference methods, making use of variational inference and direct posterior sampling. The proposed approaches facilitate the seamless incorporation of fixed LLM priors into both policy-based and value-based RL frameworks. Our experiments show that incorporating LLMbased action priors significantly reduces exploration and optimization complexity, substantially improving sample efficiency compared to traditional RL techniques, e.g., using LLM priors decreases the number of required samples by over 90% in offline learning scenarios. Traditional approaches to SDM, such as optimal control (Garcia et al., 1989), heuristic search (Świechowski et al., 2023) and reinforcement learning (RL) (Mnih, 2013), have seen substantial success. Notably, AlphaGo (Silver et al., 2016) and AlphaStar (Vinyals et al., 2019), both based on deep reinforcement learning (DRL), have achieved human-level proficiency in the games of Go and StarCraft II, respectively. However, these methods still suffer from high computational complexity, along with poor generalizability and limited applicability across diverse domains (Dulac-Arnold et al., 2015; Cobbe et al., 2019). Recently, Large Language Models (LLMs) have emerged as effective tools for tackling diverse general-purpose tasks, such as in dialogue systems (Brooks et al., 2023), decision-making (Zhao et al., 2024a), and mathematical reasoning (Imani et al., 2023).

Understanding and designing biomolecules, such as proteins and small molecules, is central to advancing drug discovery, synthetic biology, and enzyme engineering. Recent breakthroughs in Artificial Intelligence (AI) have revolutionized biomolecular research, achieving remarkable accuracy in biomolecular prediction and design. However, a critical gap remains between AI's computational power and researchers' intuition, using natural language to align molecular complexity with human intentions. Large Language Models (LLMs) have shown potential to interpret human intentions, yet their application to biomolecular research remains nascent due to challenges including specialized knowledge requirements, multimodal data integration, and semantic alignment between natural language and biomolecules. To address these limitations, we present InstructBioMol, a novel LLM designed to bridge natural language and biomolecules through a comprehensive any-to-any alignment of natural language, molecules, and proteins. This model can integrate multimodal biomolecules as input, and enable researchers to articulate design goals in natural language, providing biomolecular outputs that meet precise biological needs. Experimental results demonstrate InstructBioMol can understand and design biomolecules following human instructions. Notably, it can generate drug molecules with a 10% improvement in binding affinity and design enzymes that achieve an ESP Score of 70.4, making it the only method to surpass the enzyme-substrate interaction threshold of 60.0 recommended by the ESP developer. This highlights its potential to transform real-world biomolecular research.

Large Language Models (LLMs) have demonstrated remarkable capabilities across a wide range of natural language processing and reasoning tasks. However, their performance in the foundational domain of arithmetic remains unsatisfactory. When dealing with arithmetic tasks, LLMs often memorize specific examples rather than learning the underlying computational logic, limiting their ability to generalize to new problems. In this paper, we propose a Composable Arithmetic Execution Framework (CAEF) that enables LLMs to learn to execute step-by-step computations by emulating Turing Machines, thereby gaining a genuine understanding of computational logic. Moreover, the proposed framework is highly scalable, allowing composing learned operators to significantly reduce the difficulty of learning complex operators. In our evaluation, CAEF achieves nearly 100% accuracy across seven common mathematical operations on the LLaMA 3.1-8B model, effectively supporting computations involving operands with up to 100 digits, a level where GPT-4o falls short noticeably in some settings.

This paper investigates the challenges and potential solutions for improving machine learning systems for low-resource languages. State-of-the-art models in natural language processing (NLP), text-to-speech (TTS), speech-to-text (STT), and vision-language models (VLM) rely heavily on large datasets, which are often unavailable for low-resource languages. This research explores key areas such as defining "quality data," developing methods for generating appropriate data and enhancing accessibility to model training. A comprehensive review of current methodologies, including data augmentation, multilingual transfer learning, synthetic data generation, and data selection techniques, highlights both advancements and limitations. Several open research questions are identified, providing a framework for future studies aimed at optimizing data utilization, reducing the required data quantity, and maintaining high-quality model performance. By addressing these challenges, the paper aims to make advanced machine learning models more accessible for low-resource languages, enhancing their utility and impact across various sectors.

Large language models (LLMs) are primarily designed to understand unstructured text. When directly applied to structured formats such as tabular data, they may struggle to discern inherent relationships and overlook critical patterns. While tabular representation learning methods can address some of these limitations, existing efforts still face challenges with sparse high-cardinality fields, precise numerical reasoning, and column-heavy tables. Furthermore, leveraging these learned representations for downstream tasks through a language based interface is not apparent. In this paper, we present an innovative and scalable solution to these challenges. Concretely, our approach introduces a multi-tier partitioning mechanism that utilizes power-law dynamics to handle large vocabularies, an adaptive quantization mechanism to impose priors on numerical continuity, and a distinct treatment of core-columns and meta-information columns. To facilitate instruction tuning on LLMs, we propose a parameter efficient decoder that interleaves transaction and text modalities using a series of adapter layers, thereby exploiting rich cross-task knowledge.